Cathepsin E expression by normal and premalignant cervical epithelium

We have investigated the expression of the aspartic proteinase cathepsin E and HLA-DR and the presence of HPV16 in normal squamous epithelium (n = 8) and low-grade (n = 21) and high-grade (n = 14) intraepithelial squamous lesions of the uterine cervix. Immunohistochemistry of cervical biopsies revealed that up-regulation of cathepsin E expression was related to increasing severity of the cervical intraepithelial neoplasia (CIN). Up-regulation of protein was associated with increased message as assessed by in situ hybridization. Langerhans cells and the majority of koilocytes did not express detectable cathepsin E levels. Although there was also an up-regulation of HLA-DR expression by cervical keratinocytes in cervical intraepithelial neoplasia lesions, as determined by immunohistochemistry, no significant correlation was found between HLA-DR and cathepsin E expression in these lesions; neither was expression of cathepsin E correlated to the presence of HPV16, detected by polymerase chain reaction. The expression of cathepsin E, an aspartic proteinase that is reported to play a role in antigen processing for presentation by class II major histocompatibility complex molecules, is associated with cellular dedifferentiation in cervical intraepithelial neoplasia.     

Numerical Filling Simulation of Injection Molding Using Three-Dimensional Model

1 Introduction During injection moulding, the rheological response of polymer melts is generally non-Newtonian and nonisothermal with the position of the moving flow front. Because of these inherent factors, it is difficult to analyze the filling process. Therefore, simplifications usually are used. For example, in middle-plane technique and dual domain technique [1], because the most injection molded parts have the characteristic of being thin but generally of complex shape, the Hele-Shaw …     

Procedural Tree Modeling with Guiding Vectors

We propose guiding vectors to augment graph‐based tree synthesis, in which trees are collections of least‐cost paths in a graph. Each node has an associated guiding vector; edges parallel to the guiding vector are cheap, but edges are more expensive when their orientation differs from the guiding vector. We further propose an incremental method for assigning guiding vectors over the graph, in which a node's guiding vector is an incremental rotation of that of its parent. We present a complete procedural system for tree modeling; our use of guiding vectors enables the graph‐based method to produce high‐quality tree models resembling a variety of real‐world tree species.     

注塑成形模拟技术在模具设计中的应用

在一模多腔的注塑模具设计中,合理地设计分流道和浇口的尺寸,保证塑料熔体以相同的成形压力和温度,在同一时间充满型腔一直是设计的重点和难点。以非自然平衡浇注系统为重点,阐述了浇道和冷却系统的优化算法以及如何利用华塑三维模拟成形分析软件进行流动模拟和工艺优化。     

标准件库管理系统中的知识重用技术研究

通过分析知识重用在标准件库管理系统中的应用层次,分别介绍了特征重用、标准件重用、装配关系重用以及设计过程重用的理论基础和实现方法,从而实现了在UG平台的上标准件设计过程的自动化,有效提高了产品设计的效率和质量。     

人为粗糙度强化换热机理分析及数值模拟

对人为粗糙度强化换热机理进行了分析,讨论了影响人为粗糙度强化换热的因素。以某特定型号的热成形模具为例,对模具外冷却表面有/无人为粗糙度的冷却进行了数值模拟和对比,初步评估了人为粗糙度的强化换热效果。计算和分析表明:在热成形模具外冷却表面合理地设置人为粗糙度有利于强化对模具的冷却,提高生产效率。     

微细塑性成形中第Ⅰ类尺度效应的研究

对板料在单向拉伸和自由弯曲过程中所发生的第Ⅰ类尺度效应进行了研究，应用表面层的概念建立了分析模型，解释了单向拉伸和自由弯曲过程中屈服应力和弯曲力减小的原因。通过实验进行了验证。     

模具行业“十二五”发展规划

<正>模具是制造业中不可或缺的特殊基础装备,主要用于高效大批量生产工业产品中的有关零部件和制件,是装备制造业的重要组成部分,其产业关联度高,技术、资金密集,是制造业各有关行业产业升级和技术进步的重要保障之一。为贯彻落实党中央、国务院关于扩市场、调结构、促平衡,加快转变经济发展方式的总体要求,促进行业健康平稳发     

氧对Mo—Si系机械合金化的影响

本文通过比较在清洁和含氧环境中Mo-Si混合粉末（Mo33Si67)的机械合金化过程，研究了氧对Mo/Si固态反应的影响。采用X射线衍射和透射电镜检测了Mo-Si混合粉末在两种球磨条件下的结构变化，结果发现：在清洁环境中，高能球磨能诱导Mo/Si之间的完全反应，并导致室温相α-MoSi2和高温相β-MoSi2的形成。然而在含氧环境中，氧的侵入不但大大减缓Mo/Si固态反应及金属硅化物的形成速度，而且还导致已形成的稳定硅化物的分解。文中从热力学和动力学两方面分析了氧对Mo/Si固态反应的影响。     

Data base or data bias?

Presents evidence from researchers (M. Straus et al [1980] and M. Schulman [1979]) that refutes L. E. Walker's (see record 1989-26311-001) claim that most violence by women is a reaction to men's violence against them. Straus et al found that among couples reporting violence, in 24% of the cases the violence was unilateral by the woman, and in 27% of the cases the violence was unilateral by the man. In a study with all female Ss, Schulman found that among those reporting violence, in 30% of the cases the violence was unilateral by the woman, and in 23% of the cases women reported unilateral violence by the male. Incidence by type of violence reported varied little as to male-to-female or female-to-male. (PsycINFO Database Record (c) 2010 APA, all rights reserved)