Regression analyses of counts and rates: Poisson, overdispersed Poisson, and negative binomial models.

The regression models appropriate for counted data have seen little use in psychology. This article describes problems that occur when ordinary linear regression is used to analyze count data and presents 3 alternative regression models. The simplest, the Poisson regression model, is likely to be misleading unless restrictive assumptions are met because individual counts are usually more variable ("overdispersed") than is implied by the model. This model can be modified in 2 ways to accommodate this problem. In the overdispersed model, a factor can be estimated that corrects the regression model's inferential statistics. In the second alternative, the negative binomial regression model, a random term reflecting unexplained between-subject differences is included in the regression model. The authors compare the advantages of these approaches. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Formal aspects of computing: LATEX style guide for authors

This guide is for authors who are preparing papers forFormal Aspects of Computing using the \(LaT_E X\) document preparation system and the FAC style file.     

Investigating different factor structures of the Psychopathy Checklist: Youth version: Confirmatory factor analytic findings.

There has been a recent push to extend the construct of psychopathy into adolescence, primarily as a result of the impressive reliability, validity, and utility of this construct in samples of adults. The value of this work rests, however, on creating an equally reliable and valid assessment tool for adolescents. One promising measure is the Psychopathy Checklist: Youth Version (A. E. Forth, D. S. Kosson, & R. D. Hare, 2003). The current study uses a large, diverse sample of serious adolescent offenders to assess the overall fit of various underlying factor structures of this measure and to test the equivalence of these models across sex and race/ethnicity. The results suggest that either a 3- or 4-factor model provides the best overall fit and that these models are invariant across sex and race/ethnicity. The decision to use the 3- or 4-factor model will likely hinge on researchers' underlying conceptualization of psychopathy, specifically whether antisocial behavior is viewed as a core feature of this construct. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Elastic Scattering Spectroscopy as a Diagnostic Tool for Apoptosis in Cell Cultures

Apoptosis, ldquoprogrammed cell death,rdquo is a cellular process exhibiting distinct biochemical and morphological changes. There is much interest regarding the role of apoptosis in cancer and the response to cancer treatment. Although apoptosis can occur spontaneously in malignant tumors and often significantly retards their growth, the initial response to successful cancer treatment is often massive apoptosis. In typical in vitro studies, current apoptosis detection methods require cell culture disruption via fixation, trypsinization, and/or staining. Our aim is to develop a nondisruptive optical method of detecting and tracking apoptosis in living cells and tissues, initially focusing on cell cultures. Such a method would allow for real-time evaluation of apoptotic progression of the same cell culture over time without perturbation or alteration. We report initial studies on the use of in vitro elastic scattering spectroscopy (ESS) to monitor changes in light-scattering properties of cells due to apoptotic morphology changes. For a sequence of times post treatment, we have measured the angle-dependent scattering at a single wavelength and also the wavelength-dependent scattering at discrete angles, of treated and control cell cultures. A novel polar nephelometer, developed in our laboratory, was used to obtain the angle-dependent scattering for the range of 90-145. Wavelength-dependent ESS measurements were made with a spectrometer, for several discrete near-forward angles. The results indicate that light scattering measurements can reliably discriminate between treated and control cells, correlating well with benchmark assays for apoptosis.     

Structural studies of synthetic peptides dissected from the voltage-gated sodium channel

Peptides representing transmembrane regions of the alpha-subunit of the voltage-gated sodium channel were synthesised and their structures analysed, using 1H NMR and CD, in trifluoroethanol and in dodecylphosphocholine micelles. Sequence analysis suggests that the channel has six regions, S1 to S6, predicted to span the membrane in four homologous domains, designated, I, II, III and IV. Presented here are studies of representatives examples of possible single spanning segments (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments IS3 and IS4. In addition, we investigated ISlink56, the putative linker region between segments IS5 and IS6. All of the peptides were found to have predominantly alpha-helical structures in both solvent systems. There was some evidence for bending of the longer helices but there was no discernible evidence for well-defined tertiary structure.     

Molecular systematics and evolution of reproductive traits of North American freshwater unionacean mussels (Mollusca: Bivalvia) as inferred from 16S rRNA gene sequences

North American freshwater unionacean bivalves are a diverse group of nearly 300 species. Unionaceans exhibit an array of conchological, anatomical, life history, and reproductive characteristics that have figured prominently in proposed classification schemes. Recently, two very different classifications of North American unionaceans have been proposed. Depending on the classification system utilized, a very different evolutionary trajectory of anatomical and reproductive features is obtained. The lack of a robust, well corroborated phylogeny of North American unionacean bivalves hinders the progress of evolutionary and ecological studies involving these species. Here we present a mitochondrial DNA (mtDNA) based phylogeny for North American unionacean mussels and compare it to previously proposed classifications. In addition, we present a 'total evidence' phylogeny which incorporates both the mtDNA sequence data and available morphological data. The molecular and total evidence phylogenies agree largely with the conclusions of a previous study based largely on immunoelectrophoretic data. North American unionaceans can be divided into two families: the Unionidae, which is comprised of most of the species and the Margaritiferidae. Within the Uniondae are two subfamilies, the Anodontinae and Ambleminae. The resultant phylogeny was used to examine the evolution of several key anatomical features including the number of gills (demibranchs) used by females to brood developing embryos, incubation length (bradytictic vs tachytictic), larval (glochidial) tooth structures, and shell texture. Both molecular and total evidence phylogenies indicate several of the aforementioned characters evolved independently or were subsequently lost or gained in several lineages.     

The inherent limits of predicting school violence.

The recent media hype over school shootings has led to demands for methods of identifying school shooters before they act. Despite the fact that schools remain one of the safest places for youths to be, schools are beginning to adopt identification systems to determine which students could be future killers. The methods used to accomplish this not only are unproven but are inherently limited in usefulness and often do more harm than good for both the children and the school setting. The authors' goals in the present article are to place school shootings in perspective relative to other risks of violence that children face and to provide a reasonable and scientifically defensible approach to improving the safety of schools. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multilevel Modeling of Two Cyclical Processes: Extending Differential Structural Equation Modeling to Nonlinear Coupled Systems.

The authors present a dynamical multilevel model that captures changes over time in the bidirectional, potentially asymmetric influence of 2 cyclical processes. S. M. Boker and J. Graham's (1998) differential structural equation modeling approach was expanded to the case of a nonlinear coupled oscillator that is common in bimanual coordination studies in which participants swing hand-held pendulums but is also applicable to social systems in general. The authors' nonlinear coupled oscillator model decomposed the fluctuations into a competitive component, unique to each individual variable, and a cooperative component that captured bidirectional influence. The authors' model also generated an index of the symmetry/asymmetry of bidirectional influence. Together, the models are useful quantitative tools for the study of interacting, changing processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)