全文获取类型
收费全文 | 1320篇 |
免费 | 5篇 |
专业分类
电工技术 | 15篇 |
综合类 | 1篇 |
化学工业 | 48篇 |
金属工艺 | 26篇 |
机械仪表 | 16篇 |
建筑科学 | 12篇 |
矿业工程 | 2篇 |
能源动力 | 4篇 |
轻工业 | 26篇 |
水利工程 | 3篇 |
石油天然气 | 6篇 |
无线电 | 76篇 |
一般工业技术 | 79篇 |
冶金工业 | 849篇 |
原子能技术 | 12篇 |
自动化技术 | 150篇 |
出版年
2021年 | 6篇 |
2018年 | 9篇 |
2017年 | 3篇 |
2015年 | 3篇 |
2014年 | 7篇 |
2013年 | 28篇 |
2012年 | 8篇 |
2011年 | 14篇 |
2010年 | 24篇 |
2009年 | 23篇 |
2008年 | 15篇 |
2007年 | 24篇 |
2006年 | 8篇 |
2005年 | 15篇 |
2004年 | 21篇 |
2003年 | 10篇 |
2002年 | 9篇 |
2001年 | 9篇 |
2000年 | 11篇 |
1999年 | 37篇 |
1998年 | 222篇 |
1997年 | 127篇 |
1996年 | 108篇 |
1995年 | 52篇 |
1994年 | 49篇 |
1993年 | 66篇 |
1992年 | 18篇 |
1991年 | 9篇 |
1990年 | 20篇 |
1989年 | 21篇 |
1988年 | 20篇 |
1987年 | 19篇 |
1986年 | 15篇 |
1985年 | 14篇 |
1984年 | 25篇 |
1983年 | 12篇 |
1982年 | 23篇 |
1981年 | 21篇 |
1980年 | 20篇 |
1979年 | 7篇 |
1978年 | 9篇 |
1977年 | 32篇 |
1976年 | 50篇 |
1975年 | 11篇 |
1974年 | 15篇 |
1973年 | 10篇 |
1972年 | 11篇 |
1971年 | 6篇 |
1970年 | 6篇 |
1966年 | 5篇 |
排序方式: 共有1325条查询结果,搜索用时 15 毫秒
1.
2.
We could not imagine a more appropriate inauguration of the Psychology of Aesthetics, Creativity, and the Arts (PACA) going to four issues per year than with a special issue honoring the life and work of the great aesthetician and psychologist, Rudolf Arnheim. PACA is off to a great start. With this move to four issues per year, we are restarting our numbering system, so this special issue is Volume 1, Issue 1. As you read the articles in this issue, we hope that you enjoy reflecting on how much Rudolf Arnheim has contributed to the field of psychology of aesthetics. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
4.
Alternative measures of pesticide use 总被引:2,自引:0,他引:2
C Barnard S Daberkow M Padgitt ME Smith ND Uri 《Canadian Metallurgical Quarterly》1997,203(3):229-244
tRNA (m5U54)-methyltransferase (RUMT) catalyzes the S-adenosylmethionine-dependent methylation of uridine-54 in the T psi C-loop of all transfer RNAs in E. coli to form the 54-ribosylthymine residue. However, in all tRNA structures, residue 54 is completely buried and the question arises as to how RUMT gains access to the methylation site. A 17-mer RNA hairpin consisting of nucleotides 49-65 of the T psi-loop is a substrate for RUMT. Homonuclear NMR methods in conjunction with restrained molecular dynamics (MD) methods were used to determine the solution structure of the 17-mer T-arm fragment. The loop of the hairpin exhibits enhanced flexibility which renders the conventional NMR average structure less useful compared to the more commonly found situation where a molecule exists in predominantly one major conformation. However, when resorting to softer refinement methods such as MD with time-averaged restraints, the conflicting restraints in the loop can be satisfied much better. The dynamic structure of the T-arm is represented as an ensemble of 10 time-clusters. In all of these, U54 is completely exposed. The flexibility of the T psi-loop in solution in conjunction with extensive binding studies of RUMT with the T psi C-loop and tRNA suggest that the specificity of the RUMT/ tRNA recognition is associated with tRNA tertiary structure elements. For the methylation, RUMT would simply have to break the tertiary interactions between the D- and T-loops, leading to a melting of the T-arm structure and making U54 available for methylation. 相似文献
5.
ND Cohen 《Canadian Metallurgical Quarterly》1993,9(1):199-212
Neurologic evaluation should be performed in horses with diseases of the head. Although neurologic examination should focus on assessing behavior, mental status, and cranial nerve evaluation, evaluation of neurologic function of other body regions should be performed. Neurologic evaluation of the head can be performed expediently by practitioners to provide useful diagnostic and prognostic information. The numerous causes of dysphagia can be classified as obstructive, painful, or neurogenic. Common causes of neurogenic dysphagia are summarized, and methods for initial diagnosis and management are described. Maintaining adequate nutrition and preventing aspiration pneumonia are principal concerns in managing horses with neurogenic dysphagia. 相似文献
6.
7.
8.
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes 总被引:1,自引:0,他引:1
M Woo R Hakem MS Soengas GS Duncan A Shahinian D K?gi A Hakem M McCurrach W Khoo SA Kaufman G Senaldi T Howard SW Lowe TW Mak 《Canadian Metallurgical Quarterly》1998,12(6):806-819
Caspases are fundamental components of the mammalian apoptotic machinery, but the precise contribution of individual caspases is controversial. CPP32 (caspase 3) is a prototypical caspase that becomes activated during apoptosis. In this study, we took a comprehensive approach to examining the role of CPP32 in apoptosis using mice, embryonic stem (ES) cells, and mouse embryonic fibroblasts (MEFs) deficient for CPP32. CPP32(ex3-/-) mice have reduced viability and, consistent with an earlier report, display defective neuronal apoptosis and neurological defects. Inactivation of CPP32 dramatically reduces apoptosis in diverse settings, including activation-induced cell death (AICD) of peripheral T cells, as well as chemotherapy-induced apoptosis of oncogenically transformed CPP32(-/-) MEFs. As well, the requirement for CPP32 can be remarkably stimulus-dependent: In ES cells, CPP32 is necessary for efficient apoptosis following UV- but not gamma-irradiation. Conversely, the same stimulus can show a tissue-specific dependence on CPP32: Hence, TNFalpha treatment induces normal levels of apoptosis in CPP32 deficient thymocytes, but defective apoptosis in oncogenically transformed MEFs. Finally, in some settings, CPP32 is required for certain apoptotic events but not others: Select CPP32(ex3-/-) cell types undergoing cell death are incapable of chromatin condensation and DNA degradation, but display other hallmarks of apoptosis. Together, these results indicate that CPP32 is an essential component in apoptotic events that is remarkably system- and stimulus-dependent. Consequently, drugs that inhibit CPP32 may preferentially disrupt specific forms of cell death. 相似文献
9.
DG Robertson TK Braden ER Urda ND Lalwani FA de la Iglesia 《Canadian Metallurgical Quarterly》1998,72(6):362-371
Tetrahydroaminoacridine (tacrine) causes morphological and functional changes in the endoplasmic reticulum, ribosomes, and mitochondria in the liver of humans and animals. In order to investigate species differences as well as to understand the morphological changes, we examined the effects of tacrine on respiration and electron transport in mitochondria isolated from rat, dog, monkey, and human liver. Tacrine produced significantly decreased respiratory control ratios (RCR) in all species at concentrations ranging from 5 to 25 microg/ml. Human mitochondria were more sensitive to tacrine effects with RCR decreased 24% at 5 microg/ml while other species were unaffected at this concentration. The tacrine effects were characterized by increased hepatic mitochondrial State 4 respiration in rats and decreased State 3 respiration in humans. Mitochondria from aged rats were more sensitive to the effects of tacrine than mitochondria from young animals, with significantly decreased RCR at 10 microg/ml in aged rats while mitochondria from young rats were unaffected at this concentration. Concomitant with the respiratory changes, mitochondrial DNA synthesis was impaired. Since tacrine undergoes extensive biotransformation, we also explored the possibility that metabolites could exert detrimental effects. The ranking order of potency for decreasing RCR caused by monohydroxylated metabolites was: tacrine > 4-OH and 7-OH > 2-OH, 1-OH, and velnacrine with the latter group of metabolites having no effect on mitochondrial respiration at concentrations up to 50 microg/ml. In vivo administration of 20 mg/kg tacrine to rats for up to 20 days caused a paradoxical increase in RCR and P/O on Day 1 and decreased RCR on Days 9 and 20, the later findings being consistent with in vitro data. From these data we propose that tacrine does not necessarily have to be metabolized to exert effects on mitochondria at different sites in the electron transport chain that differ among species. These effects are exacerbated in mitochondria from older animals and humans appear to be more sensitive than the laboratory animals studied. 相似文献
10.