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OA al-Swayeh MS al-Humayyd AA Mustafa AS al-Tuwaijri RS al-Rashed AT Ali 《Canadian Metallurgical Quarterly》1997,12(7):481-489
Recent evidence suggests that oxygen-derived free radicals are involved in mediating gastric microvascular and parenchymal cell injuries induced by ischaemia and reperfusion. Therefore, the effect of the locally acting anti-ulcer drug, sucralfate, was studied on ischaemia and reperfusion (e.g. induced gastric lesions, intraluminal bleeding, changes in vascular permeability and non-protein sulfhydryl levels in the rat stomach). Allopurinol was used as a known standard antioxidant drug. Rats were subjected to 30 min of gastric ischaemia in the presence of 100 mmol/L hydrochloric acid and reperfusion periods of 15, 30 or 60 min duration. The gastric lesions were assessed microscopically under an inverted microscope. The vascular permeability was quantified by measuring the extravasated Evans blue in the stomach. There were significantly greater numbers of gastric lesions, intraluminal bleeding and leakage of Evans blue during all reperfusion periods as compared with those of ischaemia, with maximum effects occurring at 60 min following reperfusion. Pretreatment with sucralfate (31.25-250 mg/kg, p.o.) or allopurinol (12.5-50 mg/kg, i.p.) 30 min before the procedure, dose-dependently reduced the gastric lesions, intraluminal bleeding, and decreased the vascular permeability induced by ischaemia and reperfusion. Furthermore, sucralfate dose-dependently reverses the ischaemia and reperfusion-induced depletion of mucosal non-protein sulfhydryl levels and inhibited the superoxide radical production in both cell-free xanthine-xanthine oxidase and in the stimulated polymorphonuclear cellular systems. These results suggest that the protection produced by sucralfate against gastric injury may be due to its antioxidant effects. 相似文献
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SA Khotimchenko VM Kodentsova IA Alekseeva SG Vlaskina OA Vrzhesinskaia AA Sokol''nikov LA Kharitonchik IP Aleshko-Ozhevskií LV Sheviakova 《Canadian Metallurgical Quarterly》1997,43(3):158-164
Gamma delta T-Cells represent a minor subpopulation of T-lymphocytes in man and their role in normal and diseased human skin is unknown. This article is a comprehensive review of T-lymphocytes bearing the gamma delta T-cell receptor in normal and pathological human skin. Firstly, we have documented the occurrence of gamma delta T-cells in normal skin and in a range of reactive and malignant skin conditions. We have then discussed the experimental findings regarding the repertoire used by gamma delta T-cells in normal human skin and in cutaneous disorders with an increased percentage of gamma delta T-cells. 相似文献
5.
KhKh Sharafetdinov VA Meshcheriakova OA Plotnikova 《Canadian Metallurgical Quarterly》1998,86(3):30-33
The paper analyzes left ventricular structure-fraction relationships in the development of postinfarct aneurysm. The altered internal architectonics induces to systemic hemodynamic changes, drastically elevated intraventricular pressure. This is caused by to the dysfunction of the papillary-trabecular complex in the left ventricular cavity, which in turn. This leads to the fact that the heart work as a positive-displacement pump, by losing its capacity as a centrifugal component, by making the myocardium require additional energy expenditures, which in turn appears as varying heart failure. This investigation is of definite practical value in developing adequate correction methods for postinfarct aneurysm which can occur with the retained or formed certain ratios of cardiac structures. 相似文献
6.
C Montixi C Langlet AM Bernard J Thimonier C Dubois MA Wurbel JP Chauvin M Pierres HT He 《Canadian Metallurgical Quarterly》1998,17(18):5334-5348
T-cell receptors (TCRs) upon binding to peptide-MHC ligands transduce signals in T lymphocytes. Tyrosine phosphorylations in the cytoplasmic domains of the CD3 (gammadeltaepsilon) and zeta subunits of the TCR complex by Src family kinases initiate the signaling cascades via docking and activation of ZAP-70 kinase and other signaling components. We examined the role of the low-density detergent-insoluble membranes (DIMs) in TCR signaling. Using mouse thymocytes as a model, we characterized the structural organization of DIMs in detail. We then demonstrated that TCR engagement triggered an immediate increase in the amount of TCR/CD3 present in DIMs, which directly involves the engaged receptor complexes. TCR/CD3 recruitment is accompanied by the accumulation of a series of prominent tyrosine-phosphorylated substrates and by an increase of the Lck activity in DIMs. Upon TCR stimulation, the DIM-associated receptor complexes are highly enriched in the hyperphosphorylated p23 zeta chains, contain most of the TCR/CD3-associated, phosphorylation-activated ZAP-70 kinases and seem to integrate into higher order, multiple tyrosine-phosphorylated substrate-containing protein complexes. The TCR/CD3 recruitment was found to depend on the activity of Src family kinases. We thus provide the first demonstration of recuitment of TCR/CD3 to DIMs upon receptor stimulation and propose it as a mechanism whereby TCR engagement is coupled to downstream signaling cascades. 相似文献
7.
Jean-Michel L. Bernard 《电信纪事》1994,49(11-12):673-683
The time-scattering of an electromagnetic wave by a wedge-shaped region in a lossy medium, both with frequency dependent electric characteristics, is analyzed for plane wave and line source illuminations. New exact analytical expressions, satisfying explicitely the causality and allowing useful physical decompositions of the field, are obtained in these cases, using the particularities of the harmonic response in Sommerfeld-Maliuzhinets integral, especially original properties of the spectral function attached to it. 相似文献
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Pure cardiolipins (1,3-diphosphatidylglycerol) were prepared from mitochondria of heart, liver and kidney from 21-day-old
male Wistar rats and submitted toNaja naja venom phospholipase A2 (EC 3.1.1.4) action. Incubation conditions were controlled carefully, and a complete hydrolysis of cardiolipin to lysocardiolipin
{di [1 (1″) acylsn-glycero-3-phosphoryl] 1′, 3′-sn-glycerol} and fatty acids from positions 2 (2″) was obtained in less than two hr practically without side reactions. Cardiolipins
from the three organs contained low levels of saturated fatty acids; stearic acid accounted for 0.4–0.7% and palmitic acid
for 1.4–3.5% of total fatty acids. These percentages apparently depended on the organ. In all three cases, linoleic acid was
the major component, but its percentage varied from 62–78% of total fatty acids. Acyl chains linked to positions 1 (1″) of
all three cardiolipin preparations exhibited a similar pattern; they were composed of linoleic acid for 85–89%. This fatty
acid also was the main component esterified at position 2 (2″), but its percentage was much more variable: from 39.8% in heart
to 51.2% in kidney and 67.8% in liver mitochondria. The remaining acids comprised octadecenoic and polyunsaturated fatty acids
with more than 18 carbon atoms in different proportions. As opposed to other phospholipids,cis-vaccenic acid, and not oleic acid, was the main octadecenoic acid present in cardiolipins.
Octadecenoic acids were nine- to 10-fold more concentrated at positions 2 (2″) than at positions 1 (1″). The percentage ofcis-vaccenic acid was four- to five-fold higher than that of oleic acid at positions 2 (2″), whereas oleic acid dominated at
positions 1 (1″). From results presented in this study and selected literature data, it may be concluded that fatty acids
are asymmetrically distributed in cardiolipins of different origins, with linoleic acid showing a definite preference for
position 1 (1″). 相似文献
10.
Bernard G. Duda A. Haddad Y. Harrus G. 《IEEE transactions on pattern analysis and machine intelligence》1989,15(12):1567-1578
Epsilon is a testbed for monitoring distributed applications involving heterogeneous computers, including microcomputers, interconnected by a local area network. Such a hardware configuration is usual but raises difficulties for the programmer. First, the interprocess communication mechanisms provided by the operating systems are rather cumbersome to use. Second, they are different from one system to another. Third, the programmer of distributed applications should not worry about system and/or network aspects that are not relevant for the application level. The authors present the solution chosen in Epsilon. A set of high-level communication primitives has been designed and implemented to provide the programmer with an interface independent of the operating system and of the underlying interprocess communications facilities. A program participating in a distributed application can be executed on any host without any change in the source code except for host names 相似文献