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J Cremer G Steinhoff M Karck T Ahnsell M Brandt OE Teebken D Hollander A Haverich 《Canadian Metallurgical Quarterly》1997,12(5):753-758
OBJECTIVE: Encouraging results on myocardial preconditioning in experimental models of infarction, stunning or prolonged ischemia raise the question whether preconditioning techniques may enhance conventional cardioplegic protection used for routine coronary surgery. METHODS: A prospective clinical trial was conducted to investigate the effect of additional ischemic normothermic preconditioning prior to cardioplegic arrest applying cold blood cardioplegia in patients scheduled for routine coronary surgery (3 vessel disease, left ventricular ejection fraction > 50%). Two cross clamp periods of 5 min with the hearts beating in sinus rhythm were applied followed by 10 min of reperfusion, each (n = 7, group I). Inducing moderate hypothermia cold blood cardioplegia was delivered antegradely. In control groups, cold intermittent blood cardioplegia (n = 7, group II) was used alone. Coronary sinus effluents were analyzed for release of creatine kinase (CK), CK-MB, lactate, and troponin T at 1, 3, 6, 9, and 12 h. In addition, postoperative catecholamine requirements were monitored. RESULTS: The procedure was tolerated well, and no perioperative myocardial infarction in any of the groups studied occurred. Concentrations of lactate tended to be higher in group I, but this difference was not significant. In addition, no significant differences for concentrations of CK, CK-MB, and troponin T were found. Following ischemic preconditioning an increased dosage of dopamine was required within the first 12 h postoperatively (group I: 2.63 +/- 1.44 microg/kg/min, group II: 0.89 +/- 1.06 microg/kg/min). CONCLUSIONS: Combining ischemic preconditioning and cardioplegic protection with cold blood cardioplegia does not appear to ameliorate myocardial protection when compared to cardioplegic protection applying cold blood cardioplegia alone. Inversely, contractile function seemed to be impaired when applying this protocol of ischemic preconditioning. 相似文献
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S Petrasch LJ van Tits HJ Motulsky OE Brodde MC Michel 《Canadian Metallurgical Quarterly》1993,43(8):904-908
The effects of the antiasthmatic drug ketotifen (CAS 34580-13-7) on human mononuclear leukocytes were studied in vitro and in vivo. In vitro ketotifen concentration-dependently inhibited mitogen-stimulated lymphocyte proliferation. High ketotifen concentrations also inhibited T-lymphocyte mitogen- and adenosine triphosphate stimulated increases in intracellular Ca2+ in lymphocytes and the U937 human monocyte precursor cell line, respectively; this involved inhibition of both Ca2+ influx and intracellular mobilization. In in vivo experiments, treatment of healthy volunteers with 1 mg ketotifen b.i.d. for 7 d did not alter the number or subset composition of circulating lymphocytes. Moreover, the mitogen-stimulated in vitro proliferation of lymphocytes obtained before and after ketotifen treatment in vivo was similar. It is concluded that high ketotifen concentrations can inhibit the activation of resting lymphocytes in vitro but standard ketotifen treatment does not notably affect the number of function of circulating lymphocytes in vivo. 相似文献
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OE Santana Rodríguez ML Malé Gil JF HernándezSantana JM Limi?ana Ca?al AM Martín Sánchez 《Canadian Metallurgical Quarterly》1998,14(6):555-561
Von Hippel-Lindau disease (VHL) is an autosomal dominant tumour syndrome caused by germline mutations of the VHL tumour suppressor gene located on chromosome 3p25-26. In VHL tumours may occur in 14 different target organs, including the eye. Retinal angiomas are considered the first manifestation of VHL disease in 43% of cases, and the cumulative probability of developing a retinal angioma in one or both eyes rises during each decade of life, reaching 80% for patients over 80 years old. Since 1976 patients with VHL at the University Hospital of Utrecht and their at-risk relatives have been screened periodically by a multidisciplinary team. Long-term follow-up ophthalmological data were analysed with special attention to natural course and results of treatment. In addition, we looked for a genotype-phenotype correlation. Retinal angiomas were found in all families. In one large family with a missense mutation (V170D) of the VHL gene, in which the complete spectrum of visceral- and central nervous system (CNS) features of VHL is present, macular, parapapillary, optic disc and ora serrata angiomas were also found. In general, however, a clear-cut genotype-phenotype correlation could not be found. Only early detection and treatment of peripheral retinal angiomas can be expected to decrease the percentage of patients with decreased visual acuity. Therefore, early detection and treatment of these tumours is of paramount importance. Ophthalmological screening of patients and persons at risk should start as early as possible. In patients with apparently sporadic retinal angiomas it is advisable to perform germline DNA analysis, since the risk of developing VHL is high, especially if the angiomas are bilateral, or unilateral and multifocal, if the patient is young, or if there is a family history suggestive of VHL. 相似文献
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Braun-Falco together with Marghescu described 1965 for the first time the clinical picture of bullous congenital poikilodermia. In reviewing 15 cases of the literature and one own case this disease is discussed here as an own nosological entity within the congenital poikilodermias and it is suggested to use the designation "Braun-Falco-Marghescu-Syndrome" according to the first describers. 相似文献
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Charles A. Cravotta III Robin A. Brightbill Michael J. Langland 《Mine Water and the Environment》2010,29(3):176-199
Acidic mine drainage (AMD) from legacy anthracite mines has contaminated Swatara Creek in eastern Pennsylvania. Intermittently
collected base-flow data for 1959–1986 indicate that fish were absent immediately downstream from the mined area where pH
ranged from 3.5 to 7.2 and concentrations of sulfate, dissolved iron, and dissolved aluminum were as high as 250, 2.0, and
4.7 mg/L, respectively. However, in the 1990s, fish returned to upper Swatara Creek, coinciding with the implementation of
AMD treatment (limestone drains, limestone diversion wells, limestone sand, constructed wetlands) in the watershed. During
1996–2006, as many as 25 species of fish were identified in the reach downstream from the mined area, with base-flow pH from
5.8 to 7.6 and concentrations of sulfate, dissolved iron, and dissolved aluminum as high as 120, 1.2, and 0.43 mg/L, respectively.
Several of the fish taxa are intolerant of pollution and low pH, such as river chub (Nocomis micropogon) and longnose dace (Rhinichthys cataractae). Cold-water species such as brook trout (Salvelinus fontinalis) and warm-water species such as rock bass (Ambloplites rupestris) varied in predominance depending on stream flow and stream temperature. Storm flow data for 1996–2007 indicated pH, alkalinity,
and sulfate concentrations decreased as the stream flow and associated storm-runoff component increased, whereas iron and
other metal concentrations were poorly correlated with stream flow because of hysteresis effects (greater metal concentrations
during rising stage than falling stage). Prior to 1999, pH < 5.0 was recorded during several storm events; however, since
the implementation of AMD treatments, pH has been maintained near neutral. Flow-adjusted trends for 1997–2006 indicated significant
increases in calcium; decreases in hydrogen ion, dissolved aluminum, dissolved and total manganese, and total iron; and no
change in sulfate or dissolved iron in Swatara Creek immediately downstream from the mined area. The increased pH and calcium
from limestone in treatment systems can be important for mitigating toxic effects of dissolved metals. Thus, treatment of
AMD during the 1990s improved pH buffering, reduced metals transport, and helped to decrease metals toxicity to fish. 相似文献
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Correction of temperature-induced spectral variation by continuous piecewise direct standardization 总被引:2,自引:0,他引:2
In process analytical applications it is not always possible to keep the measurement conditions constant. However, fluctuations in external variables such as temperature can have a strong influence on measurement results. For example, nonlinear temperature effects on near-infrared (NIR) spectra may lead to a strongly biased prediction result from multivariate calibration models such as PLS. A new method, called Continuous Piecewise Direct Standardization (CPDS) has been developed for the correction of such external influences. It represents a generalization of the discrete PDS calibration transfer method and is able to adjust for continuous nonlinear influences such as the temperature effects on spectra. It was applied to shortwave NIR spectra of ethanol/water/2-propanol mixtures measured at different temperatures in the range 30-70 degrees C. The method was able to remove, almost completely, the temperature effects on the spectra, and prediction of the mole fractions of the chemical components was close to the results obtained at constant temperature. 相似文献
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BACKGROUND AND OBJECTIVE: To evaluate the response of intraocular pressure (IOP) to retrobulbar and peribulbar anesthesia. PATIENTS AND METHODS: Patients were prospectively masked and randomized to receive either 4 cc of retrobulbar anesthesia (X = 29) or 6 cc of peribulbar anesthesia (X = 30), each consisting of a 50:50 mixture of 2% xylocaine and 0.75% bupivacaine with 150 units of hyaluronidase. IOPs were measured pre-anesthesia and 1, 2, and 5 minutes post-anesthesia in nonglaucoma patients undergoing cataract extraction and intraocular lens implantation. RESULTS: Mean IOPs in the retrobulbar group as determined with a tonometer were 18.24, 18.66, 19.14, and 17.86 mm Hg pre-anesthesia and 1, 2, and 5 minutes post-anesthesia, respectively. In the peribulbar group, the mean IOPs were 18.53, 21.20, 20.40, and 19.20 mm Hg, respectively. The 1-minute pressures in the two groups were statistically different (P = .023). Within the peribulbar group, the 1- and 2-minute pressures were statistically different from the pre-anesthesia IOP (P = .001 and P = .018, respectively). CONCLUSION: Peribulbar anesthesia, with its higher volume of anesthetic (6 vs 4 cc), results in a higher initial IOP. This difference was slight and short lived, and occurred in the absence of any external ocular compression. This study may have application in avoiding elevation of IOP in select patients undergoing a local procedure. 相似文献
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