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In experiments on male rabbits with the lack of insulin it is been revealed violations after the past immobilization the intensivity and duration of neutrophilic leukocytosis decrease, contents of lysosomes in neutrophils, activity of acid phosphatase. By lysosomal ferments don't determine the can observer discordance of processes of coagulation, fibrinolysis, kininogenesis. 相似文献
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M. C. Adetuniji O. O. Atanda C. N. Ezekiel A. O. Dipeolu S. V. A. Uzochukwu J. Oyedepo C. A. Chilaka 《European Food Research and Technology》2014,239(2):287-296
Many individuals are not only food insecure but chronically exposed to high levels of mycotoxins through their diets in many developing countries. Seventy composite samples of stored maize grains were collected from farmers’ storage structures in five agro-ecological zones (AEZs) of Nigeria where maize is predominantly produced between August 2011 and February 2012. The grains were analysed for mycotoxin contamination with the liquid chromatography tandem mass spectrometry method and mycotoxin occurrence maps constructed from the database of the distribution of the toxins. A risk assessment was also carried out in order to provide information on the extent of human exposure to the toxins. Twelve regulated mycotoxins with negative economic and public health consequences were detected in the maize grains across the AEZs at concentrations exceeding the maximum allowable limits including AFM1 that was detected for the first time in Nigerian maize. There is a high risk of contamination of the stored grains by Nigerian consumers especially in the Derived and Southern Guinea Savannas, resulting in a national burden of between 126.85 and 38,682.29 DALYs. Intervention strategies are therefore needed across the AEZs to ensure that safe and wholesome foods are made available to the populace. 相似文献
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AG Baranovskii TG Kanyshkova AS Mogelnitskii VA Naumov VN Buneva EI Gusev AN Boiko TA Zargarova OO Favorova GA Nevinsky 《Canadian Metallurgical Quarterly》1998,63(11):1239-1248
It is known that in the blood of patients with some autoimmune diseases catalytically active antibodies hydrolyzing proteins, DNA, and RNA may be detected. In the present work homogeneous preparations of IgG antibodies (Ab) possessing high affinity for nucleic acids (NA) were obtained for the first time from blood and cerebrospinal fluid of patients with multiple sclerosis (MS). The fraction of IgG Ab as well as its Fab fragments and isolated light chains of both kappa- and lambda-types were shown to catalyze effectively the hydrolysis of DNA and RNA. It is shown by different methods that the capability for nucleic acid hydrolysis is an intrinsic property of the polyclonal Ab. NA-hydrolyzing Ab were detected in the blood of 69 of 72 and in the cerebrospinal fluid of 5 of 5 examined MS patients, while they were not detected in the blood of any of 50 healthy donors examined. Comparison of relative rates of RNA hydrolysis and of the substrate specificity in hydrolysis of various model RNAs--cCMP, poly(U), poly(A), and poly(C)--revealed pronounced differences of MS antibodies from ribonucleases of human blood, ribonuclease A, and all earlier described abzymes. The abzymes are usually characterized by relatively low specific activities in comparison with that of normal enzymes catalyzing analogous reactions. Ab from the blood of MS patients are the first example of autoabzymes whose specific activity in RNA hydrolysis is comparable or even higher than that of pancreatic ribonuclease A--one of the most active RNA-hydrolyzing enzymes. 相似文献
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In Sardinia the close association of sheep, dogs and humans still exists in some parts of the region, so that ideal conditions persist for the perpetuation of the parasite's life cycle. Two factors contribute to the spread of the disease: the practice of slaughtering sheep at home and the proliferation of dogs, mainly strays. This paper reviews the epidemiological picture and the economic consequences of the disease in man and livestock, strongly suggesting that this endemic disease is a major public health problem. 相似文献
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A retrospective review was conducted to evaluate the influence of risk factors for human immunodeficiency virus (HIV) infection on the outcome of patients with end-stage renal disease (ESRD). The records of all patients seen at Howard University Hospital between February 1984 and July 1994 with a diagnosis of HIV infection were reviewed. Two hundred seventy-eight patients had a diagnosis of renal failure; 38 of these patients developed end-stage renal failure requiring dialysis. Risk factors for HIV infection in these patients were intravenous drug abuse, homosexual behavior, bisexual preference, and blood transfusion. None of these factors consistently influenced the survival of HIV-infected patients with ESRD. 相似文献
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A patient with a pelvic silicone prosthesis is presented. The sonographic and computed tomographic features in such patients can be confusing and incorrectly interpreted unless the radiologist knows that the prosthesis had been inserted as a radioprotective device. 相似文献
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