To treat or not to treat: comparison of different criteria used to determine whether weight loss is to be recommended

Background  

Excess body fat is a major risk factor for disease primarily due to its endocrine activity. In recent years several criteria have been introduced to evaluate this factor. Nevertheless, treatment need is currently assessed only on the basis of an individual's Body Mass Index (BMI), calculated as body weight (in kg) divided by height in m². The aim of our study was to determine whether application of the BMI, compared to adiposity-based criteria, results in underestimation of the number of subjects needing lifestyle intervention.     

Exploiting the high-frequency performance of low-voltage low-power SC filters

This paper investigates the design of low-voltage low-power switched-capacitor (SC) filters for high-frequency applications by using the clock-booster approach. In particular, our proposed SC filter architecture uses single-ended double-sampling integrator cells based on low-voltage operational transconductance amplifiers which take advantage of dynamic biasing and the clock-booster technique to drive the switch transistors. To validate its high-frequency capability, two low-pass elliptic SC filters respectively with a corner frequency of 6 and 8-MHz, were designed in a 0.35-/spl mu/m CMOS process. Both are suitable for telecom applications and can operate with a power supply as low as 1.5 V, while dissipating 11 mW. Measurements showed that for an output amplitude of 1 V/sub pp/, their total harmonic distortions were maintained well below -40 dB in their bandwidths. Comparisons with other SC filter implementations in the literature, which highlight the quality of our implementation are also provided.     

Optical properties of high-density dispersions of particles: application to intralipid solutions

We propose to study the scattering properties of dense distributions of spherical scatterers by resorting to an iterative solution of the Foldy-Twersky equation for the propagation of the coherent field. As a result of the first step of the iterative procedure, the host medium is substituted by an effective medium of complex refractive index to account for the multiple-scattering processes that occur among the particles. Although we truncate the above-mentioned iterative procedure to the second step, the results of our calculations are in excellent agreement with previous experimental results of Zaccanti et al. ("Measurement of optical properties of high-density media," to be published in Applied Optics) for the scattering coefficient of Intralipid solutions up to a volume density of 15% and show a limited disagreement at a volume density of 22%.     

Switched capacitor compatible minimum-maximum function

A new block for the implementation of the function is presented. It is based on structures commonly used in SC circuits and is fully compatible with this approach. The circuit was realised in a 1.2 μm standard CMOS technology. The experimental results show good agreement with the predicted results     

UV Radiation and the Skin

UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance.     

Synthesis, characterization and antimicrobial activity of conjugates based on fluoroquinolon-type antibiotics and gelatin

Different fluoroquinolon-type antibiotics were conjugated to gelatin with the aim to synthesize biomacromolecules with antimicrobial properties. The covalent linkage of the antibiotic was performed by a radical process involving the residues in the side chains of gelatin able to undergo oxidative modifications. The conjugation of antibiotic moieties onto the protein structure was confirmed by FT-IR, UV–Vis, fluorescence, and calorimetric analyses. Biocompatibility tests were performed on human bone marrow mesenchymal stromal cells and the antibacterial properties of bioactive polymers were investigated by appropriate tests against Klebsiella pneumoniae and Escherichia coli. With regard to the tests conducted in the presence of E. coli, a minimum inhibitory concentration (MIC) ranging from 0.05 to 0.40 μg mL^?1 was recorded, while in the presence of K. pneumoniae this concentration varies from 0.10 to 1.60 μg mL^?1. In all the conjugates, the drug moieties retain their biological activity and the MIC values are lower than the resistance parameters of fluoroquinolon-type antibiotics versus Enterobacteriacae. The collected data suggest a broad range of applications, from biomedical to pharmaceutical and food science for all conjugates.     

1 V CMOS output stage with excellent linearity

A CMOS low-voltage output stage based on a push-pull topology is proposed. It is driven by a differential signal and its symmetric topology provides excellent intrinsic linearity. It can work with a power supply as low as 1 V and when loaded with a 500 /spl Omega/ resistor it exhibits negligible even harmonic components whilst odd components are maintained well below -20 dB up to 900 mV/sub pp/ of the output signal. Moreover, the output stage includes a simple current control which accurately sets the bias condition.