An expert decision support system for network routing: a case study

The paper presents a case study of the development of an expert decision support system which uses simple heuristic methods for fast determination of routes for simultaneous signals in a transmission network of limited capacity. It illustrates how heuristic solutions can be embodied in a model-based DSS and how the standard decision support literature, although intuitively appealing, provides little practical assistance in system construction or classification     

Nursing performance measures go public

Over 100 years ago, Florence Nightingale showed caregivers how to analyze mortality data to improve their clinical processes. The nurses of today are facing a new performance measurement challenge. Consumers of health care services want information that will help them compare quality among providers. This article describes the types of nursing performance measures most appropriate to include on these public-oriented report cards and several issues that influence report card design and dissemination.     

Graphical representation of prism coupling into thin films

A natural framework for evaluating prism-coupler performance is provided by a recently developed geometrical construction in which refraction through a prism for an arbitrary angle of incidence is represented by an ellipse. The useful operating range of a prism coupler is represented by the portion of the representational ellipse that appears within a window determined by the mode propagation conditions of a thin-film-substrate system.     

p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx

The anti-metastatic effect of Z-100, an immunomodulatory arabinomannan extracted from Mycobacterium tuberculosis, was investigated in mice bearing B16 melanoma cells. Treatment of BF10 mice implanted with high metastatic B16F10 melanoma cells with a 10 mg/kg dose of Z-100 resulted in the reduction of experimental pulmonary metastasis as compared with that of BF10 mice treated with saline. The number of pulmonary metastatic colonies in BF1 mice (mice implanted with low metastatic B16F1 melanoma cells) was greatly increased after the inoculation of CD4+ CD11b+ CD281+ TCR alphabeta+ type 2 T cells (F10-Th2 cells) derived from BF10 mice, while only a few metastatic colonies were demonstrated in lungs of BF1 mice inoculated with naive CD4+ T cells. However, the numbers of metastatic colonies in BF1 mice were not increased when they were inoculated with the F10-Th2 cell fraction derived from Z-100-treated BF10 mice and the generation of F10-Th2 cells in BF10 mice was effectively suppressed by the Z-100 treatment. These results suggest that Z-100 inhibits pulmonary metastasis of B16 melanoma through the regulation of tumor-associated Th2 cells, which are a key cell in the acceleration of tumor metastasis.     

Self-generated validity and other effects of measurement on belief, attitude, intention, and behavior.

Drawing from recent developments in social cognition, cognitive psychology, and behavioral decision theory, we analyzed when and how the act of measuring beliefs, attitudes, intentions, and behaviors affects observed correlations among them. Belief, attitude, or intention can be created by measurement if the measured constructs do not already exist in long-term memory. The responses thus created can have directive effects on answers to other questions that follow in the survey. But even when counterparts to the beliefs, attitudes, and intentions measured already exist in memory, the structure of the survey researcher's questionnaire can affect observed correlations among them. The respondent may use retrieved answers to earlier survey questions as inputs to response generation to later questions. We present a simple theory predicting that an earlier response will be used as a basis for another, subsequent response if the former is accessible and if it is perceived to be more diagnostic than other accessible inputs. We outline the factors that determine both the perceived diagnosticity of a potential input, the likelihood that it will be retrieved, and the likelihood that some alternative (and potentially more diagnostic) inputs will be retrieved. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Traffic engineering standards in IP-networks using MPLS

The explosive growth of the Internet over the last few years has made the IP protocol suite the most predominant networking technology. Furthermore, the convergence of voice and data communications over a single network infrastructure is expected to happen over IP-based networks. Traditional IP-networks offer little predictability of service, which is often unacceptable for applications such as telephony, as well as for emerging and future real-time applications such as telemedicine. One of the primary goals of traffic engineering is to enable networks to offer predictable performance. Due to the need for better traffic control by network service providers, there has been considerable activity in the Internet Engineering Task Force to develop standards for traffic engineering in IP-based networks. This article discusses the direction taken by the IETF and some of the recent standardization efforts for traffic engineering using multiprotocol label switching (MPLS). Our primary focus is on the signaling protocols developed for this purpose     

A twin study of dental dimension. II. Independent genetic determinants

To demonstrate the presence of independent genetic determinants of multiple correlated tooth dimensions from twin data, a multivariate analysis was performed on the covariance matrices of monozygotic and dizygotic within-pair differences for mesiodistal and buccolingual dimensions of 28 teeth of the secondary dentition. The results provided strong evidences that the correlation among tooth dimensions is primarily genetic in origin, probably attributable to the pleiotropic action of either independent genes or groups of genes. Among the genetic factors that were identified, one appeared to affect the maxillary teeth in general while a second influenced primarily the anterior mandibular teeth. There was a striking tendency for homologous measurements on the right and left sides to be associated with the same genetic factor. In contrast, genetic determination of the maxillary and mandibular dentition seemed to be independent of each other, and a wider range of genetic factors were found to influence the mandibular than the maxillary teeth, suggesting that a differential degree of evolutionary stability may have been achieved in the teeth of the two jaws.     

Inhibition of insulin degradation by nonsuppressible insulin-like activity

Nonsuppressible insulin-like activity, provided by three sources, was evaluated for its effect on the proteolytic degradation of insulin utilizing insulin protease obtained from rat liver homogenate as well as liver cell membranes. All three preparations of nonsuppressible insulin-like activity were found to be competitive inhibitors of insulin degradation. In addition human plasma was fractionated yielding an acetone precipitate which was found to have nonsuppressible insulin-like activity and to be a competitive inhibitor of insulin protease.