Synthesis and characterisation of carboxylic acid and diphenylphosphine derivatives in the 1,3-diyne series: Spectral properties of polydiacetylene carboxylates

Symmetrically substituted 1,3-diynes containing hydroxyalkyl ( 1a-d ), bromoalkyl ( 1e-h ) (diphenylphosphinyl) ( 1i-k ) and carboxyalkyl ( 2a-d ) substituents have been prepared and characterised; the phosphine derivative ( 1k ) has been converted with alkyl iodides ( RI ; R = Me, Et) into bis(phosphonium) salts ( 1l and m ). During preparation of the diynedioic acid. ( 2a ), the non-centrosymmetrical diyne, HO₂CCH₂C?C—C?C(CH₂)₂OH ( 3 ), was also isolated. ⁶⁰Co γ-Irradiation of diacetylene monomers ( 2a – d ) and 10,12-tricosadiyn-1-oic acid gave the corresponding polydiacetylene derivatives ( 4a – d and 5 ), respectively. Rubidium salts of ( 4c ) and ( 4d ), a barium salt of ( 4c ), and a potassium salt of ( 5 ) were prepared and isolated; soluble potassium salts of the carboxylic acid polymers ( 4 ) were generated in aqueous solution. The effects of changes in pH on the UV/visible absorption spectra of aqueous solutions of selected carboxylic acid polydiacetylenes have been recorded, and are discussed.     

Processing of engineering ceramics with high power CO2 lasers

The hardness and brittleness of high performance engineering ceramics such as zirconia, aluminia, silicon carbide and silicon nitride makes traditional processing very expensive and time consuming. Efforts have been made to cut thick commercial ceramics with a continuous wave CO₂ laser. The results obtained so far are very promising and materials up to 10 mm in thickness have been cut successfully.     

Anaesthesia--room for advancing nurse practice?

Nurse anaesthesia has been a topic of debate in the UK for many years. I use the word debate loosely because in order to debate one has to be in possession of the facts about the chosen subject. Certainly the subject of nurse anaesthesia evokes very mixed emotions ranging from cautious interest to complete denial that this type of practitioner is of any benefit to the health care industry. Comments such as "it is an idea taken up by some states in the USA and by a number of other countries with a mixed degree of success" and "British anaesthesia ... would neither be improved nor made cheaper by the introduction of nurse anaesthesia" are made from, in this author's opinion, a lack of knowledge about this type of practitioner and their benefits. Accurate and unbiased information about nurse anaesthesia is hard to come by in the UK, therefore, how can accurate comments and opinions be made about this subject.     

Confidence intervals for dependent data: Equating non-overlap with statistical significance

We revisit the problem of determining confidence interval widths for the comparison of means. For the independent two-sample (two-sided) case, Goldstein and Healy (1995) draw attention to the fact that comparisons based on 95% error bars are not very effective in assessing the statistical significance of the difference in means and derive the correct confidence interval for such a comparison. We provide an extension to Goldstein and Healy (1995) to account for the correlation structure and unequal variances. We use the results to develop rules of thumb for evaluating differences, in an exploratory manner, like Moses (1987) and Cumming (2009), from the independent case. We illustrate the method for the simple comparison of two means in a real data set, provide R code that may be easily implemented in practice, and discuss the extension of the method to other applied problems.     

Toxicoproteomics and its application to human health risk assessment

Toxicoproteomics is the use of proteomic technologies to better understand environmental and genetic factors, toxic mechanisms, and modes of action in response to acute exposure to toxicants and in the long-term development of diseases caused or influenced by these exposures. Use of toxicoproteomic technologies to identify key biochemical pathways, mechanisms, and biomarkers of exposure and toxicity will decrease the uncertainties that are associated with human health risk assessments. This review provides an overview of toxicoproteomics from human health risk assessment perspectives. Key toxicoproteomic technologies such as 2-D gel-based proteomic methods and toxicoproteomic approaches are described, and examples of applications of these technologies and methodologies in the risk assessment context are presented. The discussion includes a focus on challenges and future directions.     

Some notes on cellular logic operators

Cellular logic machines used for feature extraction in pattern recognition have increased in speed to the point of making it possible to execute programs equivalent to 1 billion general-purpose computer instructions in 1 TV frame time. Unfortunately, most cellular logic operators (CLO's) are designed ad hoc. It is important, therefore, to begin to systematize the generation of algorithms using CLO sequences for pattern analysis. These notes systematically analyze some aspects of CLO's which are used in shape discrimination and idealization and in object counting and sizing. New extensions of subfield numbering schemes in the hexagonal tessellation are introduced.     

Background pattern removal by power spectral filtering

A new method for removing periodic background patterns from pictures is presented. The basic spatial frequency composition of the pattern is determined from an estimate of the power spectrum of the picture. A convolutional restoration kernel is then created from a modified version of the power spectrum. The method is extremely effective and can be automated.     

A 100-MHz macropipelined VAX microprocessor

A macropipelined CISC microprocessor was implemented in a 0.75-μm CMOS 3.3-V technology. The 1.3-million-transistor custom chip measures 1.62×1.46 cm² and dissipates 16.3 W. The 100-MHz parts were benchmarked at 50 SPEC marks. The on-chip clocking system and several high-performance logic and circuit techniques are described. Macroinstruction handling, micropipeline management, and control store structures highlight the design architecture. The hierarchical array organization and fast tag comparison technique of the primary cache are discussed. Power estimation procedures are outlined, and the results are compared to measurements. Physical design and verification methods, and CAD tools are also described. After extensive functional verification efforts are described, chip and system test results are presented