Effect of moditen-depot therapy on the duration and quality of remissions in schizophrenia patients

The authors studied the effectiveness of out-patient treatment by Moditen-Deppt of 128 schizophrenic patients. A comparison of the previous remissions appearing during usual pharmacotherapy and remissions seen during Moditen-Depot treatment depicted statistically significant differences, indicating a distinct prevention of exacerbations due to this preparation, an increase in the duration and improved quality of remissions. Such improved remissions were expressed in lesser severity, in a decrease of psychopathological disturbances, changes qualified as a "mollification of a defect" and an improvement of some socio-clinical indices.     

Secondary immunodeficiency and its myelopid correction in patients with infiltrative and disseminated pulmonary tuberculosis

The combined treatment of 53 patients with colonic cancer, using neoadjuvant intraarterial polychemotherapy (IAPCT), was conducted. The trustworthy lowering of the catheterized artery thrombosis occurrence rate, the tumor recurrence-by 7%, distant metastases-by 13.9%, two-year survival increase-by 15.5% was promoted by verapamil application as a IAPCT modifier.     

The effect of mutation in the NS gene on the biological properties of the influenza virus

The biological properties of influenza virus strain A/PR/8/34, virulent from mice, and its variant 25A-1, obtained by hybridization with avirulent strain A/Leningrad. This reassortant 25A-1 included 7 genes of its virulent parent strain and only gene NS of the avirulent one, which contained a single mutation in position 798 (ATG=>ATA), inducing amino acid change MET=>IIe in position 100 of the polypeptide chain of protein NS2. The loss of pathogenic properties by strain A/PR/8/34 was achieved by replacing the single gene NS with an analogous mutant gene of the variant strain A/Leningrad, adapted to low temperatures. The single-gene reassortant 25A-1 thus obtained possessed, besides decreased capacity for multiplication in the lungs of mice, ts phenotype on MDCK cells, but exhibited no thermal sensitivity in cell systems of avian origin. The above-mentioned phenotypic changes in reassortant 25A-1 were due to disturbances in virus-specific protein synthesis at early and late stages, as detected in vivo and in vitro.     

Early signs of renal pathology in small intensity chemical exposure

Occupational exposure to vapours, gases and aerosols promotes increase of renal diseases incidence. Wider use of anamnestic data is recommended during preliminary and regular check-ups of this population.     

Immune status indices during the combined treatment of patients with duodenal peptic ulcer

Indices were studied of the immunological status (cell-mediated, humoral immunity) before and after the multimodality pathogenetic treatment of patients with duodenal ulcer. Noted in the course of the complex treatment were changes in the immunoregulatory index, NK-cells, IgM. The findings obtained suggest that the immune defence may be depressed, with the vascular factor, infection (Helicobacter pylori) having their part in the genesis of duodenal ulcer.     

Conditioned reflexes in relation to temporal intervals

The paper outlines the results of experiments on twelve rats aimed at studying conditioned reflexes of discrimination of both absolute and relative characteristics of time intervals (30 and 180; 10 and 90; 5 and 45; 5 and 40; 5 and 35; 5 and 30 sec). The data obtained are discussed in the light of I.P. Pavlov's hypothesis regarding the physiological mechanism of conditioning to time.     

Differential diagnosis of ischemic heart disease and cardialgia by means of pharmacological tests in the polyclinical practice

The possibility of differential diagnosis of ischemic heart disease and cardialgia at a polyclinic is analyzed. A total of 1110 patients with a preliminary diagnosis of ischemic heart disease were examined. In 214 of them the data gathered during many years of observations have cast doubt on the validity of this diagnosis. The patients of this group were made to undergo tests with potassium chloride and obsidan. Subject to appraisal were the ECG reaction and an analysis of angular variations of the vectors in the terminal portion of the ventricular complex. The described tests were shown to help determine the significance of "functional" or "organic" changes of the myocardium in the genesis of repolarizational ECG perturbances.