A distributed adverse drug reaction detection system using intelligent agents with a fuzzy recognition‐primed decision model

Discovering unknown adverse drug reactions (ADRs) in postmarketing surveillance as early as possible is highly desirable. Nevertheless, current postmarketing surveillance methods largely rely on spontaneous reports that suffer from serious underreporting, latency, and inconsistent reporting. Thus these methods are not ideal for rapidly identifying rare ADRs. The multiagent systems paradigm is an emerging and effective approach to tackling distributed problems, especially when data sources and knowledge are geographically located in different places and coordination and collaboration are necessary for decision making. In this article, we propose an active, multiagent framework for early detection of ADRs by utilizing electronic patient data distributed across many different sources and locations. In this framework, intelligent agents assist a team of experts based on the well‐known human decision‐making model called Recognition‐Primed Decision (RPD). We generalize the RPD model to a fuzzy RPD model and utilize fuzzy logic technology to not only represent, interpret, and compute imprecise and subjective cues that are commonly encountered in the ADR problem but also to retrieve prior experiences by evaluating the extent of matching between the current situation and a past experience. We describe our preliminary multiagent system design and illustrate its potential benefits for assisting expert teams in early detection of previously unknown ADRs. © 2007 Wiley Periodicals, Inc. Int J Int Syst 22: 827–845, 2007.     

Intercomparison of Thermophysical Property Measurements on an Austenitic Stainless Steel

The results of an inter laboratory comparison of thermal conductivity, thermal diffusivity, specific heat capacity, and thermal expansion measurements on austenitic stainless steel in the temperature range between 20 and 1000°C are presented here. Mean values are presented for the physical properties studied. Reliable relative expanded uncertainties can be stated for the properties determined, which were achieved by applying good measurement practice, i.e., 3% for thermal expansion, 5% for specific heat capacity and thermal diffusivity, and 6% for thermal conductivity. The mean values derived from this intercomparison agree well with the results of a previous intercomparison in 1990. An erratum to this article is availabale at .     

CMOS inverters based positive type second generation current conveyor

A new versatile class AB low-voltage second generation current conveyor based on CMOS inverters operating in transconductance mode is presented in this letter. Against traditional design based on CCII+, the circuit is able to operate at low supply voltages and offers numerous advantages like class AB operation, large voltage and current swing, synthesis from digital inverters. Simulation results from a typical 0.35 μm CMOS process had demonstrated the circuit capability to operate at high frequency over wide voltage and wide current swings. The proposed circuit operation has been acted from measurements with the HEF4069UBP from Philips semiconductors [1].     

Thermal budget calculations, design aspects, and device performanceof high-Tc air-bridged microbolometers

The thermal properties of an air-bridged microbolometer have been evaluated on the basis of a finite element calculation scheme for the first time. The numerical results show that the performance of the device's sensitively depends on geometry and layout. The degree of thermal coupling and interaction with the heat sink affects the thermal time constant and frequency range of operation. For identical geometries, experimental and modeled data are in good agreement. The length of the air-bridge is defining the effective thermal time constant but has little effect on the thermal responsivity. An unusually high responsivity has been calculated for configurations where the thermal coupling to the heat sink has been minimized. This design leads to an increase of responsivity of a factor of 200 and would establish superior operation of the device even at ambient temperature