The bromodomain and extra terminal (BET) family of bromodomain-containing proteins (BCPs) have been the subject of extensive research over the past decade, resulting in a plethora of high-quality chemical probes for their tandem bromodomains. In turn, these chemical probes have helped reveal the profound biological role of the BET bromodomains and their role in disease, ultimately leading to a number of molecules in active clinical development. However, the BET subfamily represents just 8/61 of the known human bromodomains, and attention has now expanded to the biological role of the remaining 53 non-BET bromodomains. Rapid growth of this research area has been accompanied by a greater understanding of the requirements for an effective bromodomain chemical probe and has led to a number of new non-BET bromodomain chemical probes being developed. Advances since December 2015 are discussed, highlighting the strengths/caveats of each molecule, and the value they add toward validating the non-BET bromodomains as tractable therapeutic targets. 相似文献
We present a spectral rendering technique that offers a compelling set of advantages over existing approaches. The key idea is to propagate energy along paths for a small, constant number of changing wavelengths. The first of these, the hero wavelength, is randomly sampled for each path, and all directional sampling is solely based on it. The additional wavelengths are placed at equal distances from the hero wavelength, so that all path wavelengths together always evenly cover the visible range. A related technique, spectral multiple importance sampling, was already introduced a few years ago. We propose a simplified and optimised version of this approach which is easier to implement, has good performance characteristics, and is actually more powerful than the original method. Our proposed method is also superior to techniques which use a static spectral representation, as it does not suffer from any inherent representation bias. We demonstrate the performance of our method in several application areas that are of critical importance for production work, such as fidelity of colour reproduction, sub‐surface scattering, dispersion and volumetric effects. We also discuss how to couple our proposed approach with several technologies that are important in current production systems, such as photon maps, bidirectional path tracing, environment maps, and participating media. 相似文献
Handwriting recognition is used for the prediction of various demographic traits such as age, gender, nationality, etc. Out of all the applications gender prediction is mainly admired topic among researchers. The relation between gender and handwriting can be seen from the physical appearance of the handwriting. This research work predicts gender from handwriting using the landmarks of differences between the two genders. We use the shape or visual appearance of the handwriting for extracting features of the handwriting such as slanteness (direction), area (no of pixels occupied by text), perimeter (length of edges), etc. Classification is carried out using the Support Vector Machine (SVM) as a classifier which transforms the nonlinear problem into linear using its kernel trick, logistic regression, KNN and at the end to enhance the classification rates we use Majority Voting. The experimental results obtained on a dataset of 282 writers with 2 samples per writer shows that the proposed method attains appealing performance on writer detection and text-independent environment.
In this paper, a method for writing composable TLA+ specifications that conform to the formal model called Masaccio is introduced. Specifications are organized in TLA+ modules that correspond to Masaccio components by means of a trace-based semantics. Hierarchical TLA+ specifications are built from atomic component specifications by parallel and serial composition that can be arbitrary nested.
While the rule of parallel composition is a variation of the classical joint-action composition, the authors do not know about
a reuse method for the TLA+ that systematically employs the presented kind of a serial composition. By combining these two composition rules and assuming
only the noninterleaving synchronous mode of an execution, the concurrent, sequential, and timed compositionality is achieved. 相似文献
The aim of this paper is to generalize the conic domain defined by Kanas and Wisniowska, and define the class of functions which map the open unit disk E onto this generalized conic domain. A brief comparison between these conic domains is the main motivation of this paper. A correction is made in selecting the range interval of order of conic domain. 相似文献
Chitosan-based nanocomposites containing gamma-treated carbon nanotubes (CNTs) were developed for controlled release of pesticide. The CNTs were irradiated under gamma irradiation in air at different doses. The transmission electron microscopic images of gamma-treated CNTs showed disentanglement of the tubes without distorting their tubular structure which effectively increased the dispersion properties of CNTs in nanocomposites. X-ray diffraction analysis of CNTs showed some structural changes, and an irradiation dose of 150 kGy is the most effective. Azinphos methyl (AZM) was selected as a model drug, and its release was studied using HPLC technique. Controlled release response of CNTs-based nanocomposites opens a new avenue for pesticides applications because it requires less quantity of pesticides. As a result, the side effects of pesticide in our environment are minimized. 相似文献
Elucidation of the structure of naturally existing or synthesized substances is an important criterion in the study of materials to predict the application of the substance. In this study, polylactide was doped with nano-aluminium oxide and nano-cupric oxide with 1 and 3 mg of concentration variants. The interaction between the polymer matrix and the nanoparticles has been studied using Fourier transform infrared. Successful doping of the polymer has been observed. Attention has been drawn to check the intermolecular bonding in films having varying thicknesses, films prepared at higher sonication temperatures, and chemical homogeneity of the doped polymer films. 相似文献
The one‐dimensional heterogeneous model of an industrial multitubular packed‐bed ethylene oxide (EO) reactor was developed using the equation‐oriented platform Aspen Custom Modeler. Reactor operation was optimized in terms of maximized EO production and selectivity and enhanced safety related to the presence of oxygen in the EO reactor. Good agreement was found between the model results during validation against the available information under identical operating conditions. The model predicts the behavior of the EO reaction and demonstrates the extent of catalyst utilization with product distribution, product yield, by‐product formation, temperature and concentration profiles, over time and along the length of the reactor or catalyst bed. The model sensitivity studies compute the optimum feed flow, oxygen concentration, feed pressure, etc. and suggest the best operational philosophy. 相似文献