A systematic antilipidemic structure-activity relationship study was carried out on a series of alcoyl- and benzoyl-phenoxy-carboxylic acids

A systematic antilipidemic structure-activity relationship study was carried out on a series of alcoyl- and benzoyl-phenoxy-carboxylic acids. The introduction of a p-chlorobenzoyl moiety into the original phenoxy-isobutyric acid enhanced antilipidemic activity significantly. Chlorine meta substitution or chlorine disubstitution abolished activity. Among the esters synthetized, the isopropylester has been selected for further studies.     

Buss-Durkee assessment and validation with violent versus nonviolent chronic alcohol abusers.

26 male 27–47 yr old chronic alcohol abusers who had been violent while intoxicated and 25 male 34–52 yr old nonviolent alcohol abusers were administered the Buss-Durkee Hostility-Guilt Inventory. All Ss were Caucasians with a reported daily intake of ethanol of 227 ml?±?89 ml for at least the last 5 yrs. Violence was documented by police records and by patient and family reports. Violent drinkers scored significantly higher than controls on the Total Hostility score and on subscales measuring Assault, Irritability, Verbal Hostility, Indirect Hostility, and Resentment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)