Ex vivo and in vivo Evaluation of [18F]PR04.MZ in Rodents: A Selective Dopamine Transporter Imaging Agent

N‐4‐Fluorobut‐2‐yn‐1‐yl‐2β‐carbomethoxy‐3β‐phenyltropane (PR04.MZ) has been developed as dopamine transporter (DAT) ligand for molecular imaging. It contains a terminally fluorinated, conformationally constrained nitrogen substituent that is well suited for the introduction of fluorine‐18. The present report describes the pharmacological characterisation of [¹⁸F]PR04.MZ. The ligand shows an IC₅₀ value of 2 nM against human DAT, whereas the IC₅₀ value against human serotonin transporter and human noradrenalin transporter are lower (110 nM and 22 nM , respectively). Furthermore, its ex vivo organ distribution, its binding profile in the rat brain and reversibility of binding were examined. A μPET study illuminates a fast kinetic profile and specific binding to rat DAT.     

凝固条件和镁对Al-Si11.0合金组织的影响

研究了宇向凝固时冷却条件和镁元素对Ａｌ－Ｓｉ１１．０合金树枝晶结构和共晶组织的影响。试验结果表明,随着冷却速度的增加,Ａｌ－Ａｉ１１．０合一次枝晶和二镒分枝间距都显著减小,在较小的冷却速度时,加入镁元素后合金的二镒分枝间距明显增大,而在冷却速度大于１６０Ｋ／ｍｉｎ时,则没有影响。试验还发现,加入镁元素后,冷却速度对共晶成分的影响显示减小,是合 共晶组织变细。在试验范围内,Ａｌ－Ｓｉ１１．０合金中加     

Surface mount digital package reliability

This paper compares the reliability of four surface mount package styles with the standard through-hole package. Three test boards were fabricated and subjected to environmental and electrical stresses. The relative package performances of SOICs, butt-soldered DIPs, surface mounted DIPS, and through-hole DIPs were found to be equal when subjected to stresses exceeding those expected in normal use. PLCC packages were found to be slightly less reliable in humidity environments than the other packages.     

Wilma E. Hirst (1914-2005).

This is an obituary for Wilma Elizabeth Hirst. Hirst was a pioneer in the history of school psychology who came from a background in teaching and educational psychology, worked her way through graduate school, balanced home life and career, and forged a distinguished career in teaching, psychological service, and school administration. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Geschichte des Tiegelstahlverfahrens und des Werkzeugstahls

Erfindung des Tiegelstahls durch Benjamin Huntsman im Jahre 1740. Bauarten koks- und generatorgasbeheizter Tiegelöfen. Metallurgie des Tiegelstahlverfahrens. Anfänge der legierten Werkzeugstähle. Verfahrenswechsel durch Erschmelzen von Qualitätsstahl im Siemens-Martin-Ofen und Elektrolichtbogenofen. Geschichtlicher Abriß der Tiegelstahlwerke in Deutschland, der Schweiz, in Österreich und England.     

Visualization of Neural Network Predictions for Weather Forecasting

Recurrent neural networks are prime candidates for learning evolutions in multi‐dimensional time series data. The performance of such a network is judged by the loss function, which is aggregated into a scalar value that decreases during training. Observing only this number hides the variation that occurs within the typically large training and testing data sets. Understanding these variations is of highest importance to adjust network hyper‐parameters, such as the number of neurons, number of layers or to adjust the training set to include more representative examples. In this paper, we design a comprehensive and interactive system that allows users to study the output of recurrent neural networks on both the complete training data and testing data. We follow a coarse‐to‐fine strategy, providing overviews of annual, monthly and daily patterns in the time series and directly support a comparison of different hyper‐parameter settings. We applied our method to a recurrent convolutional neural network that was trained and tested on 25 years of climate data to forecast meteorological attributes, such as temperature, pressure and wind velocity. We further visualize the quality of the forecasting models, when applied to various locations on the Earth and we examine the combination of several forecasting models.     

LEKIDs Developments for mm-Wave Astronomy

Microwave Kinetic Inductance Detectors (MKIDs) have recently drawn the attention of the low-temperature detectors community. Easy fabrication, high sensitivity, small time constants and most notably the intrinsic capability to frequency multiplexing open new possibilities to applications that need very large array sizes and/or high speed read-out. Lumped Element Kinetic Inductance Detectors (LEKIDs) designed and fabricated in our collaboration have already shown good on sky performances, but new developments are needed for future multi-thousands-pixels instruments. In this contribution we present such ongoing developments: a new LEKIDs design, optimized to be dual polarization sensitive; use of new materials such as TiN in order to reach better signal to noise ratios; new solutions to minimize the cross-talk between pixels in order to achieve a better control of the resonance positions in frequency space. We discuss present lab measurements of the optical performances and recent improvements of the read-out electronics.     

X-Ray Imaging Using LEKIDs

We present the detection of 5.9 keV X-rays in a silicon wafer utilising an array of frequency multiplexed Kinetic Inductance Detectors. The readout electronics consists of a programmable digital electronics with an integrated 12-bit ADC, operating with a maximum frequency of 100 MHz. We implement a lumped element geometry, realising pixels as small as possible in order to achieve better position resolution. The whole system allows the simultaneous readout of 14 pixels with a bandwidth of 300 kHz, but it is easily scalable up to 100 pixels. A higher bandwidth detection, with less pixels, allows the reconstruction of the photon absorption position in the substrate up to hundreds of microns. This technological development could be applied in the next future to large area X-Ray Imaging. A better understanding of high energy photon and particle detection is also crucial for the space implementation of LEKIDs for mm-astronomy, where data loss due to Cosmic particles could be a major issue.