Effects of beta-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection

OBJECTIVES: The age-dependence of the development of ventricular arrhythmias was studied in German shepherd dogs with inherited ventricular arrhythmias and sudden death. BACKGROUND: A colony of German shepherd dogs has been established that exhibit inherited ventricular arrhythmias and sudden death. The incidence of arrhythmias increases with age. Because ventricular tachycardia is associated with bradycardia, it was hypothesized that the increased incidence of arrhythmias was related to age-dependent slowing of heart rate. METHODS: Arrhythmia counts and RR intervals were measured from serial ambulatory ECG recordings obtained in 71 dogs (1-48 weeks). In addition, 19 dogs were challenged with phenylephrine (10 micrograms/kg i.v.) at 15, 28, and 45 weeks of age, 10 dogs were challenged with epinephrine (1 microgram/kg i.v.) at 3, 5, 7, 9, 11, 18, and 28 weeks of age, and 10 dogs were challenged at 28 weeks with epinephrine (2.5 micrograms/kg i.v.), before and after propranolol (0.5 mg/kg i.v.). RESULTS: The incidence and severity of ventricular arrhythmias increased between 7 and 28 weeks of age and decreased between 28 and 44 weeks of age. The age-dependent increase in the incidence of ventricular tachycardia was associated with age-dependent reductions in sinus rate. Baroreflex-mediated slowing of the heart rate unmasked arrhythmias in young animals that did not spontaneously display arrthythmias and exacerbated existing arrhythmias in older animals. However, the magnitude of baroreflex-induced bradycardia was similar from 7-18 weeks of age, yet the incidence of arrhythmias increased progressively. Moreover, the waning of ventricular arrhythmias in older animals was not associated with more rapid sinus rates. CONCLUSION: The risk for sudden death in dogs with inherited ventricular arrhythmias increases with age in part because of age-dependent slowing of heart rate and in part because of other heart-rate-independent factors. The correspondence between the development of ventricular tachycardia and sinus pauses is consistent with the hypothesis that ventricular arrhythmias are initiated by early afterdepolarization-induced triggered activity.     

Climate change gains more from nuclear substitution than from conservation

We show the massive reduction achievable, in both emissions and climate change impact, from enhanced nuclear energy use on the forecasts of future world energy use and its associated environmental impacts. A range encompassing the major scenarios for the World's energy demand have been analyzed using the latest version of the climate-modeling MAGICC/SCENGEN software (Version 4.1). We have updated and predicted the impacts of 80% substitution with CO₂-free sources (likely predominantly nuclear) for coal-fired electricity (by 2030) and for transportation fuel (by 2040). For transportation, hydrogen produced by CO₂-free sources would replace gasoline and diesel fuels. In this paper, to bracket the range of futures, we simply focus on two scenarios from the Intergovernmental Panel on Climate Change's (IPCC), one (A1FI) that is energy-profligate and one (B2) that is energy-conserving.The results show that, interestingly, projected average global temperatures for all scenarios are fairly similar until about 2035 (a further rise beyond the 1990 average temperature of +0.75 ± 0.1 K) regardless of energy usage and its sources. However, by 2050, the different IPCC scenarios diverge markedly. Understandably, A1FI is projected to have noticeably stronger effects than B2 on average global temperatures (about 0.3 K more in 2050) but the effect is much stronger over land at mid and high latitudes (up to almost 1 K more). What is most striking is that the substitution of CO₂-free sources gives projected average temperature rises in 2050 over key land areas (North America and China) that are very similar for the two energy-use scenarios—typically 1–1.5 K because A1FI's additional energy is predominantly supplied by nuclear. In contrast, projected rises with the unaltered cases are markedly different being about 2.5 K for A1FI and 1.5–2 K for B2. The projected changes in rainfall distribution show similar patterns, especially for the expected increases in higher latitudes.With the assumption of no additional policies for substitution of energy sources beyond 2040, temperature divergence between the two scenarios of relative energy profligacy or conservation grows in the latter half of the 21st century, even with substitution. However, the early substitution of nuclear energy and hydrogen appears to buy time and is not crucially dependent on severe, near-term curtailment of energy use. Near-term curtailment is too difficult to implement at a time of rapid industrialization of major emerging economies. Of course, proportionately larger deployments of CO₂-free energy sources are needed for more energy-intensive scenarios.Nuclear power must dominate as the source of CO₂-free energy since it is proven, dependable, available on a large scale, and economic. Social objections to nuclear energy in some countries and quarters are seen as well-meaning but misguided distractions from solving the energy and environmental crises that are now facing world sustainability. The time for real technical, social and political action is now.     

Experimental heat transfer in supercritical water flowing inside channels (survey)

This literature survey is for heat transfer to supercritical water flowing in channels. The objectives are to assess the work that was done and to understand the specifics of heat transfer at these conditions. Our exhaustive literature search, which included over 450 papers, showed that the majority of experimental data were obtained in vertical tubes, some data in horizontal tubes and just a few in other flow geometries including bundles. In general, the experiments showed that there are three heat transfer modes in fluids at supercritical pressures: (1) normal heat transfer, (2) deteriorated heat transfer with lower values of the heat transfer coefficient (HTC) and hence higher values of wall temperature within some part of a test section compared to those of normal heat transfer and (3) improved heat transfer with higher values of the HTC and hence lower values of wall temperature within some part of a test section compared to those of normal heat transfer. The deteriorated heat transfer usually appears at high heat fluxes and lower mass fluxes. Also, a peak in HTC near the critical and pseudo-critical points was recorded. Due to the limited number of publications that are devoted to heat transfer in bundles cooled with water at supercritical pressures, more work is definitely needed to provide the additional information for design purposes.     

Hydraulic resistance of fluids flowing in channels at supercritical pressures (survey)

This literature survey is devoted to hydraulic resistance of water and carbon dioxide flows at supercritical pressures. The objectives are to assess previous studies that were done in the area of hydraulic resistance of fluids at supercritical pressures flowing in channels of various geometries and to understand the specifics of pressure drop at these conditions. The literature search showed that the majority of experimental data were obtained in vertical tubes, some data were obtained in horizontal tubes and just a few of them in other flow geometries including bundles. In general, hydraulic resistance data are limited compared to the heat transfer data at supercritical pressures. Differences in pressure drop between supercritical and subcritical forced convection seem to be related to significant variations in thermophysical properties near the critical and pseudocritical points. Due to these variations, satisfactory analytical and numerical methods have not yet been developed especially in turbulent flows and at high heat fluxes. In general, the pressure drop in supercritical fluid flow consists of four components: pressure drop due to frictional resistance, due to local flow obstruction, due to acceleration of flow and due to gravity. The total pressure drop at supercritical pressures can be estimated using general correlations for pressure drop at subcritical pressures with correction factors for the effect of significant thermophysical properties variations and high heat fluxes. Only one paper was devoted to pressure drop in tight short bundles cooled with water at supercritical pressures. Therefore, more experimental work is needed to estimate the total pressure drop in various bundle designs with the objective of providing reliable information for designing supercritical water nuclear reactors.     

Social reinforcement in attitude change.

Ss were exposed to an attitude different than one they had expressed previously with the purpose of seeing whether postcommunicative conversation would reflect attempts at reducing such cognitive dissonance. Analyzing the conversation of women who had been exposed to attitudes concerning toilet training which was different than the one they had expressed indicated that they did tend to reduce cognitive dissonance by seeking out information that either agreed with their formally held notion or the newly advocated one. From Psyc Abstracts 36:04:4GD09M. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Correction to Romney (2008).

Reports an error in "Consulting for diversity and social justice: Challenges and rewards" by Patricia Romney (Consulting Psychology Journal: Practice and Research, 2008[Jun], Vol 60[2], 139-156). The author refers to "Paul Winn." The referenced author's last name was printed incorrectly. The correct spelling is Winum. (The following abstract of the original article appeared in record 2008-07255-002.) Consulting and training for cultural diversity is both challenging and rewarding. This article issues a call to face the challenges of diversity consulting and describes strategies and approaches for successful work. Using examples from the author's practice, the author calls on consultants to (1) get up to speed with knowledge about diversity and social justice, (2) avoid consultations that are too superficial, (3) balance content and process, (4) find ways to sustain themselves and their clients, and (5) work for the Common Good. A social justice frame is seen as a necessary adjunct to promoting equity and excellence in organizations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationship between formal thought disorder and retardation in schizophrenia.

17 schizophrenics admitted into the hospital less than 6 mo before were compared on Bannister's Grid Test of Schizophrenic Thought Disorder with 19 schizophrenics admitted over 6 mo before and with a group of 17 nonschizophrenic, psychiatric controls under 3 conditions: fast rate of responding, slow rate of responding, and in-between rate of responding. It was predicted that the schizophrenics would show more thought disorder under fast than slow conditions and that the recently admitted schizophrenics would be more thought disordered than the earlier admitted schizophrenics. Contrary to expectations, the patients tended to show less thought disorder on the test when their responses were speeded than when they were encouraged to take their time. Moreover, the earlier admitted schizophrenics showed more thought disorder than the recently admitted schizophrenics under all 3 conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relating reflectance spectra space to Munsell color appearance space

The goal is to construct a simple model relating the conceptually defined Munsell color space to a physical representation of the relationship among the reflectance spectra obtained from the color chips comprising the Munsell color atlas. In the model both the Munsell conceptual system and the transformed reflectance spectra are shown to be well represented in Euclidean space, and the two spaces are related by a simple linear transformation. A practical implication is that the method allows one to compare the location of an empirical reflectance spectrum with the aiming point in the conceptual structure.     

A further attempt to differentiate violent from nonviolent offenders by means of a battery of psychological tests.

30 male Ss who had been convicted of violent offenses and 30 convicted on nonviolent offenses (mean ages 17.5 and 17.4 yrs, respectively) were administered the WAIS, Buss-Durkee Hostility Inventory (BDHI), the Hostility and Direction of Hostility Questionnaire, and the Eysenck Personality Questionnaire. Only 6 of the dependent variables differentiated between the 2 groups at or beyond the .05 level of significance. They were Information, Comprehension, Verbal IQ, Object Assembly, Full Scale IQ, and Assault. With the exception of Assault (a BDHI subscale), all the variables come from the WAIS. There were no significant differences between the 2 groups on S. B. Eysenck and H. J. Eysenck's (1975) personality dimensions of extraversion, neuroticism, and psychoticism. (French abstract) (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A longitudinal study of bacterial vaginosis during pregnancy

OBJECTIVE: To determine the longitudinal changes in the incidence of vaginosis in pregnancy. DESIGN: A prospective study of women during pregnancy. SETTING: A District General Hospital in North-West London. SUBJECTS: Seven hundred and eighteen pregnant women attending antenatal clinics. At their first attendance and subsequently, Gram-stained vaginal smears were examined and Mycoplasma hominis and Gardnerella vaginalis were sought by culture. RESULTS: Initially, 87 (12%) women had bacterial vaginosis diagnosed on Gram-stained reading of the vaginal smears. Examination of further smears, obtained from 176 women at 36 weeks of gestation, showed that those whose vaginal flora was normal initially, and who went to term, rarely developed vaginosis (three of 127, 2.4%). Samples were obtained at 36 weeks gestation from 32 women who had bacterial vaginosis initially, and went to term. In almost 50% (15 of 32) of these a normal lactobacillus-dominated flora had regenerated. Thirty-five women (5%) had initial vaginal smears graded as intermediate. From this group, six of the 17 (35%) women from whom samples were obtained at 36 weeks gestation still had flora of an intermediate pattern; 10(59%) now had normal flora and only one (6%) had developed bacterial vaginosis. Women with bacterial vaginosis were more likely to be culture-positive for M. hominis than those with normal flora (34/78 versus 10/563, odds ratio 42.73 (18.9 to 102.3) P < 0.001), or to be culture-positive for G. vaginalis than those with normal flora (35/78 versus 21/563, odds ratio 21.0 (10.75 to 41.2) P < 0.001). CONCLUSION: Pregnant women do not commonly develop bacterial vaginosis after 16 weeks gestation, and if present, it remits spontaneously in approximately half of those who reach term. As bacterial vaginosis is associated with increased rates of second trimester miscarriage and preterm delivery, any treatment aimed at its eradication in pregnancy should be given no later than the beginning of the second trimester of pregnancy.