The comorbidity of alcoholism with anxiety and depressive disorders in four geographic communities

The comorbidity of alcoholism with anxiety and depressive disorders was examined in four epidemiologic investigations from diverse geographic sites. Despite variability in lifetime prevalence rates for these disorders, there was strong cross-site consistency in the magnitude and specific patterns of comorbidity. Individuals with alcohol abuse or dependence generally experienced a twofold to threefold increased risk of anxiety and depressive disorders. Phobic conditions typically preceded the onset of alcoholism, but no systematic pattern was observed for panic or depressive disorders. Considerable heterogeneity was also observed concerning the impact of comorbid conditions on symptoms of the index disorder. While the presence of comorbid anxiety or depressive disorders was consistently associated with moderate increases in the symptoms of alcohol abuse or dependence, alcoholism was associated with large increases in the number of depressive symptoms and little or no increase in phobic symptoms. The findings are discussed in terms of the self-medication hypothesis and the etiologic heterogeneity of these forms of comorbidity in the general population.     

Symptom scales of the Diagnostic Interview Schedule: Factor results in Hispanic and Anglo samples.

The Diagnostic Interview Schedule (DIS) was designed for use in large-sample surveys of mental health to produce categorical diagnoses according to criteria such as those found in the third edition of the Diagnostic and Statistical Manual of Mental Disorders, based on structured information about lifetime symptoms provided to nonclinician interviewers. Using symptom data from a probability sample of community residents in Puerto Rico who ranged in age from 18 to 64 (N?=?1,513), we examined five clusters of items (those associated with diagnoses of affective disorders, schizophrenia, phobic disorder, somatization disorder, and alcoholism) and formed quantitative measures of psychopathology from each. We checked the factor structure of these five scales in two probability samples obtained in Los Angeles, one composed of Mexican-Americans (N?=?1,113) and one of Anglo-Americans (N?=?975). Both Los Angeles samples were restricted to persons aged 18 to 64 for these analyses. Evidence of the cross-cultural stability of the DIS Affective Symptoms and Alcoholism scales was obtained. (PsycINFO Database Record (c) 2010 APA, all rights reserved)