The present study was carried out to investigate the biochemical and morphological changes in the liver after ligation of the hepatic artery (HA) in the presence and in the absence of extrahepatic cholestasis (EHC). The study was conducted on 100 rats divided into four groups of 25 animals each: group 1, sham operation; group 2, hepatic artery ligation (HAL); group 3, bile duct ligation (BDL); and group 4, HAL plus BDL. All animals were sacrificed 7 days after surgery when total bilirubin and fractions, alkaline phosphatase (AP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in serum and on the inner hepatocyte mitochondrial membrane (IHMM); the incidence of necrosis and the volume fractions of vessels, bile ducts and hepatocytes in the liver were also determined. HAL reduces the relative volumes of bile ducts, with no changes in levels of bilirubin and fractions, AP, ALT, AST and IHMM, but HAL associated with EHC reduces duct proliferation and the liver becomes more vulnerable to necrosis. In conclusion, the normal liver depends on HA flow and this dependence is more evident in the presence of EHC. 相似文献
This paper describes the optimization of three processes applied in fabrication of a microstructured reactor for complete oxidation of volatile organic compounds. The first process involves the optimization of the electro discharge machining (EDM) method to produce a set of microchannels with a high length to diameter ratio of 100, with a standard deviation from the average diameter below 0.2%, and with a surface roughness not higher than 2.0 μm. To satisfy these criteria, fabrication of microchannels must be carried out with two machining passes in the Al51st alloy. Then, the effect of several parameters on the anodization current efficiency with respect to oxide formation was studied. The best process conditions to get a 30 μm porous alumina layer in a 0.4 M oxalic acid electrolyte, were found to be a temperature of 1 °C, an anodic current density of 5 mA/cm2, and 23 h oxidation time. At last, the resulting coatings were impregnated with an aqueous solution of copper dichromate followed by drying and calcination at 450 °C to produce active catalysts. The effect of a copper dichromate concentration, number of impregnation cycles (1 or 2), and different after-treatments on catalytic activity and stability in complete oxidation of n-butane were studied. The catalytic activity of the obtained coatings is superior to that of alumina supported pelletized catalysts even at much lower loadings of active metals. 相似文献
A mathematical model has been developed for the simulation of the ammonia oxidation in a reverse flow reactor. Computer simulations were carried out with a kinetic scheme, based upon elementary reaction steps. Aim was to explore the potential of a reverse flow reactor for selective oxidation of NH3 to produce either N2, NO, or N2O via a dedicated operation procedure. Therefore, the conversion of NH3 and the selectivity toward N2, NO, or N2O, were compared for a reverse flow operation and a steady state, once-through operation.A new operation concept of reverse flow operation in combination with a periodically lower feed concentration is proposed. The novel reactor concept shows a better performance compared to normal reverse flow operation and to steady state, once-through operation. The results indicate that reverse flow operation can be applied for manipulation of conversion and selectivity. A periodically lower feed concentration may increase the conversion, even up to levels that exceed the steady state value. 相似文献
Most heterogeneously catalyzed gas–liquid reactions in micro channels are chemically/kinetically limited because of the high
gas–liquid and liquid–solid mass transfer rates that can be achieved. This motivates the design of systems with a larger surface
area, which can be expected to offer higher reaction rates per unit volume of reactor. This increase in surface area can be
realized by using structured micro channels. In this work, rectangular micro channels containing round pillars of 3 μm in
diameter and 50 μm in height are studied. The flow regimes, gas hold-up, and pressure drop are determined for pillar pitches
of 7, 12, 17, and 27 μm. Flow maps are presented and compared with flow maps of rectangular and round micro channels without
pillars. The Armand correlation predicts the gas hold-up in the pillared micro channel within 3% error. Three models are derived
which give the single-phase and the two-phase pressure drop as a function of the gas and liquid superficial velocities and
the pillar pitches. For a pillar pitch of 27 μm, the Darcy-Brinkman equation predicts the single-phase pressure drop within
2% error. For pillar pitches of 7, 12, and 17 μm, the Blake-Kozeny equation predicts the single-phase pressure drop within
20%. The two-phase pressure drop model predicts the experimental data within 30% error for channels containing pillars with
a pitch of 17 μm, whereas the Lockhart–Martinelli correlation is proven to be non-applicable for the system used in this work.
The open structure and the higher production rate per unit of reactor volume make the pillared micro channel an efficient
system for performing heterogeneously catalyzed gas–liquid reactions. 相似文献
People of low literacy experience difficulties while participating in society. Learning support software could help alleviate these difficulties. However, there is currently no overview of theoretically and empirically sound requirements for this kind of support. This paper uses the situated cognitive engineering method to create a requirements baseline for a virtual environment to support the societal participation education of low-literates (VESSEL), based on an analysis of the domain, human factors, and current applications. Four major outcomes are presented. First, a comprehensive overview is collected of the operational demands and human factors knowledge relevant to societal participation learning for low-literate citizens. Second, this overview is translated into a list of eight functional requirements: focused on low-literate learners, set in the context of societal participation, and supported by claims of cognitive, affective, and social benefits to learning. Third, a sample of Dutch societal participation learning support programs is assessed using these requirements, to highlight both current technology best practices and discrepancies between theory and practice. Fourth, virtual learning environment technology is suggested as an ‘enabling’ technology; an overview is shown of how virtual environments, actors, and objects can beneficially enable meeting the requirements baseline. Finally, directions for future study are discussed.
The article highlights new insights into production of thin titania films widely used as catalyst support in many modern reactors including capillary microreactors, microstructured fixed-bed reactors and falling film microreactors. Dip-coating of a titania sol onto a Si substrate has been studied in the range of the sol viscosities of 1.5-2.5 mPa s and the sol withdrawal rates of 0.2-18 mm/s. Different viscosities of sols were created by addition of desired amounts of nitric acid to the synthesis mixture of titanium isopropoxide and Pluronic F127 in ethanol which allowed to control the rate of the condensation reactions. Uniform mesoporous titania coatings were obtained at the solvent withdrawal rates below 10 mm/s at sol viscosities in the range from 1.6 mPa s to 2.5 mPa s. There exists a limiting withdrawal rate corresponding to a capillary number of ca. 0.01 beyond which uniform titania films cannot be obtained. Below the limiting withdrawal rate, the coating thickness is a power function of the sol viscosity and withdrawal rate, both with an exponent of 2/3. The limiting withdrawal rate increases as the solvent evaporation rate increases and it decreases as the sol viscosity increases. 相似文献
The impact of removing the rind from fresh‐cut watermelon slices was assessed on the quality of the product during storage at 4 °C for 9 days. Flesh lycopene declined from 55.4 to 47.9 mg kg?1 f.w. and colour lightness (L*) increased from 43.2 to 45.8 after 2 days of storage. Initial heart and placental flesh firmness increased from 7.3 and 9.8 N, respectively, to 9.5 and 12.8 N after 9 days, but were unaffected by rind processing. Electrolyte leakage from placental tissue was unaffected by storage and rind. Rind presence limited juice run‐off by 47.2% and maintained mean total soluble sugar concentration in the slices at 86.0 mg mL?1 as opposed to 76.8 mg mL?1 in rind‐less slices. Change in the quality was most pronounced between 0 and 2 day of storage. Removing the rind accelerated senescence and off‐flavour production, while the presence of rind improved the overall storage stability of fresh‐cut watermelon slices. 相似文献