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Effects of unilateral striatal dopamine depletion on tongue force and rhythm during licking in rats.
Skitek Emily B.; Fowler Stephen C.; Tessel Richard E. 《Canadian Metallurgical Quarterly》1999,113(3):567
To quantitatively assess the orolingual dysfunctions produced by unilateral striatal dopamine depletions, rats first received 6-hydroxydopamine injections into the nigrostriatal bundle and were then trained to lap water from a force-sensing disk in 2-min sessions. Compared with controls and rats with moderate (75%) dopamine depletions showed decreases in number of licks, lick rhythm, and lick peak force. Rats with substantial lesions were also impaired in making initial, within-session adjustments in lick peak force but not in lick rhythm. The results confirm the presence of Parkinson-like deficits in tongue dynamics during consummatory licking behavior in rats. The methods used here should prove useful in providing quantitative measures of the efficacy of experimental therapies in this rodent model of Parkinson's disease. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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