Differential expression and distribution of focal adhesion and cell adhesion molecules in rat hepatocyte differentiation

The present study has examined the distribution of axons of differing sizes in the optic pathway of the ground squirrel. Axon diameters were measured from electron micrographs at various locations across sections of the optic nerve and tract, and total distributions and numbers were estimated. In both the nerve and tract, roughly 1.2 million optic axons were present. The population of optic axons had a unimodal size distribution, peaking at 0.9 microm in diameter and having an extended tail toward larger diameters. Local axon diameter distributions in the optic tract indicated distinct (though partially overlapping) axon diameter classes, including one of fine sizes peaking at 0.8-0.9 microm, a second of medium sizes peaking around 1.7-1.8 microm, and a third composed of the larger fibers with diameters up to 4.8 microm. The fine-caliber axons were found at all locations in the tract, and were the only axons present immediately adjacent to the pia, while the medium- and coarse-caliber axons were found at deeper locations. Curiously, the larger axons were found primarily in the medial parts of the tract, where axons from the dorsal retina normally course. A similarly restricted distribution of the larger axons was observed in the dorsotemporal parts of the optic nerve, suggesting that this difference in the tract may relate to an asymmetric distribution of ganglion cells on the retina giving rise to these axons. Measurements of axonal size taken within the optic fiber layer in dorsal and ventral parts of the retina confirmed this asymmetry, consistent with previous demonstrations of soma size differences in the dorsal versus ventral retina. The partial segregation of axons by size in the optic tract of the ground squirrel then reflects both the asymmetric distribution of retinal ganglion cell classes and the chronotopic reordering of optic axons that occurs within the chiasmatic region.     

Damage threshold prediction of hafnia-silica multilayer coatings by nondestructive evaluation of fluence-limiting defects

A variety of microscopic techniques were employed to characterize fluence-limiting defects in hafnia-silica multilayer coatings manufactured for the National Ignition Facility, a fusion laser with a wavelength of 1.053 mum and a pulse width of 3 ns. Photothermal microscopy, with the surface thermal lens effect, was used to map the absorption and thermal characteristics of 3 mm x 3 mm areas of the coatings. High-resolution subaperture scans, with a 1-mum step size and a 3-mum pump-beam diameter, were conducted on the defects to characterize their photothermal properties. Optical and atomic force microscopy were used to identify defects and characterize their topography. The defects were then irradiated by a damage testing laser (1.06 mum and 3 ns) in single-shot mode until damage occurred. The results were analyzed to determine the role of nodular and nonnodular defects in limiting the damage thresholds of the multilayer coatings. It was found that, although different types of defect were present in these coatings, the fluence-limiting ones had the highest photothermal signals (up to 126x over the host coating). The implication of this study is that coating process improvements for hafnia-silica multilayer coatings should have a broader focus than just elimination of source ejection, since high photothermal signals frequently occur at nodule-free regions. The study also demonstrates that, for optics subject to absorption-induced thermal damage, photothermal microscopy is an appropriate tool for nondestructive identification of fluence-limiting defects.     

Extended Tunability in a Two-Chip VECSEL

We demonstrate a widely tunable vertical-external-cavity surface-emitting laser (VECSEL) with a W-shaped cavity, in which two VECSEL chips serve as fold mirrors and a birefringent filter is inserted at Brewster's angle. These two chips provide much higher modal gain and broader bandwidth of the gain than a single chip does, enhancing the VECSEL tuning range and reducing the variation of tunable output power with the tuned wavelength. This two-chip VECSEL configuration makes it possible to shape the modal gain spectra of the laser or to manipulate the tuning curve of the laser by two different chips with certain gain peak detuning (offset). Multiwatts high-brightness linearly polarized output with a tuning range of 33 nm is demonstrated in such a two-chip VECSEL     

5-W Yellow Laser by Intracavity Frequency Doubling of High-Power Vertical-External-Cavity Surface-Emitting Laser

We report on the development of a high-power tunable yellow–orange laser. It is based on intracavity frequency doubling of a widely tunable, highly strained InGaAs–GaAs vertical-external-cavity surface-emitting laser operating near 1175 nm. Over 5 W of continuous-wave output power is achieved and is tunable over a 15-nm band centered at 587 nm. This compact low-cost high-power yellow–orange laser provides an innovative alternative for sodium guidestar lasers, medical and communication applications.      

Messtechnische Herausforderungen bei der Analyse von hochdynamischen Aufprallbeanspruchungen

Metrological challenges analyzing high dynamic impact on reinforced slabs The comprehension of high dynamic impact processes on reinforced concrete structures is of essential importance for the dimensioning of structures regarding exceptional loading scenarios like airplane impacts. Since, for high strain rates in comparison with quasi‐static conditions an altered material behavior appears, an adequate methodology and application of appropriate measurement is required to assess the structural behavior of building components. The present paper describes the metrological methodology and the challenges of the experimental investigations of reinforced concrete slabs under impact with loading periods of only a few μs or ms. The determination of time history curves of impact velocities, bearing forces, displacements and the determination of sound wave velocities inside the structure requires an appropriate high sampling rate with the signal recording. The results lately lead to a holistic assessment of the structural behavior and the damage phenomena of such processes.     

Fabrication of mitigation pits for improving laser damage resistance in dielectric mirrors by femtosecond laser machining

Femtosecond laser machining is used to create mitigation pits to stabilize nanosecond laser-induced damage in multilayer dielectric mirror coatings on BK7 substrates. In this paper, we characterize features and the artifacts associated with mitigation pits and further investigate the impact of pulse energy and pulse duration on pit quality and damage resistance. Our results show that these mitigation features can double the fluence-handling capability of large-aperture optical multilayer mirror coatings and further demonstrate that femtosecond laser macromachining is a promising means for fabricating mitigation geometry in multilayer coatings to increase mirror performance under high-power laser irradiation.     

Management of nevus spilus

BACKGROUND: Granulomatous gastritis is a rarely observed pathological diagnosis. This condition often mimics gastric adenocarcinoma clinically, resulting in gastric resection. However, granulomatous gastritis has long been viewed as a benign process not observed in association with adenocarcinoma of the stomach. This article describes a patient with granulomatous gastritis occurring in close proximity to an area of superficially invading gastric adenocarcinoma. METHODS: Acid-fast stains, fungal stains, standard cultures, tuberculosis cultures, and a VDRL serum test were all obtained. Both upper endoscopy and colonoscopy were performed. Chest radiographs were taken and pulmonary consultation was obtained. RESULTS: The gastric samples obtained from resection showed no evidence of foreign body reaction. The acid-fast stains, fungal stains, cultures, and VDRL were all negative. Endoscopic exams did not show granulomatous inflammation in any other part of the gastrointestinal tract. No pulmonary disease was evident on radiographic or pulmonary exam. CONCLUSION: Isolated granulomatous gastritis is a diagnosis of exclusion. The findings in this patient do not support a diagnosis of Crohn's disease, tuberculosis, sarcoidosis, syphilis, histoplasmosis, berylliosis, or foreign-body reaction. This is a unique case suggesting an association between isolated granulomatous gastritis and metaplastic mucosal changes.