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排序方式: 共有213条查询结果,搜索用时 15 毫秒
1.
Examination of the wreckage of a light aircraft revealed that approximately 20 cm was missing from one tip of the aluminum
alloy propeller. Fractographic and metallographic examination of the remaining portion of the propeller revealed extensive
grain-boundary separation in the vicinity of the fracture, and grain edges and corners rounded by corrosion on the fracture
surface. Energy dispersive X-ray analysis (EDXA) revealed fluorine on, and in the vicinity of, the fracture surface. In the
ensuing litigation, it was asserted that the crash occurred because the propeller fractured in flight as the result of intergranular
attack caused by the use of a fluorine-bearing cleaner. 相似文献
2.
Bioabsorbable composites, designed for use as rigid tissue scaffolds, were fabricated by reinforcing free radically cured poly(D,L-lactide) fumarate matrices with absorbable poly(glycolic acid) fibers. To investigate the benefits of an improved fiber/matrix interphase, fiber pretreatments were employed including surface-etching by exposure to mild acidic conditions and incorporation of 3-methacryloxypropyltrimethoxysilane as a coupling agent. SEM of composite fracture surfaces showed that fiber pretreatment yielded improved wetting and encapsulation of the fibers by the matrix resin. The composites fabricated with poly(glycolic acid) fibers which were acid-etched and pretreated with the coupling agent showed an average 41% increase in tensile strength; a representative sample displayed an increase from 73.9 MPa to 105.5 MPa, compared to the composite made from untreated fibers. 相似文献
3.
The compaction properties of an investigational drug are studied by the use of a compaction simulator. The effects of punch velocity over the range of 30-640 mm-1 on the compaction properties of the pure drug and a variety of formulas incorporating a high dose of the active compound have been investigated. The data were analyzed by applying the Heckel equation. The pure drug was found to have a high yield pressure at a relatively low punch velocity of 31 mm-1. As the punch velocity was increased there was a decrease in crushing strength, primarily as a result of increasing yield pressure. These findings indicate that the pure drug predominantly consolidated by fragmentation and elastic deformation, with a slow plastically deforming component. The information obtained on the consolidation mechanism of the pure drug and, subsequently, on model formulas were instrumental in the design and selection of a robust formula and granulation process. The advantages of conducting dosage form design and characterization studies during the early phase of tablet formulation using means such as a compaction simulator are emphasized in this investigation. 相似文献
4.
The author describe their incorporation of IDDQ testing into the design of the PA-7100LC PA-RISC microprocessor. They also discuss design guidelines, measurement techniques, results after fabrication and volume production, and suggested improvement. Their 900,000-transistor custom design supports IDDQ testing to ensure high quality without compromising 100-MHz-plus performance 相似文献
5.
6.
Activity of Fluorine‐Containing Analogues of WC‐9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii
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María N. Chao Catherine Li Melissa Storey Dr. Bruno N. Falcone Dr. Sergio H. Szajnman Prof. Dr. Sergio M. Bonesi Prof. Dr. Roberto Docampo Prof. Dr. Silvia N. J. Moreno Prof. Dr. Juan B. Rodriguez 《ChemMedChem》2016,11(24):2690-2702
Two obligate intracellular parasites, Trypanosoma cruzi, the agent of Chagas disease, and Toxoplasma gondii, an agent of toxoplasmosis, upregulate the mevalonate pathway of their host cells upon infection, which suggests that this host pathway could be a potential drug target. In this work, a number of compounds structurally related to WC‐9 (4‐phenoxyphenoxyethyl thiocyanate), a known squalene synthase inhibitor, were designed, synthesized, and evaluated for their effect on T. cruzi and T. gondii growth in tissue culture cells. Two fluorine‐containing derivatives, the 3‐(3‐fluorophenoxy)‐ and 3‐(4‐fluorophenoxy)phenoxyethyl thiocyanates, exhibited half‐maximal effective concentration (EC50) values of 1.6 and 4.9 μm , respectively, against tachyzoites of T. gondii, whereas they showed similar potency to WC‐9 against intracellular T. cruzi (EC50 values of 5.4 and 5.7 μm , respectively). In addition, 2‐[3‐ (phenoxy)phenoxyethylthio]ethyl‐1,1‐bisphosphonate, which is a hybrid inhibitor containing 3‐phenoxyphenoxy and bisphosphonate groups, has activity against T. gondii proliferation at sub‐micromolar levels (EC50=0.7 μm ), which suggests a combined inhibitory effect of the two functional groups. 相似文献
7.
8.
Ariel Cohen Peishan Liu-Synder Dan Storey Thomas J. Webster 《Nanoscale research letters》2007,2(8):385-390
Bioactive coatings are in high demand to control cellular functions for numerous medical devices. The objective of this in vitro
study was to characterize for the first time fibroblast (fibrous scar tissue forming cells) adhesion and proliferation on
an important polymeric biomaterial (silicone) coated with titanium using a novel ionic plasma deposition (IPD) process. Fibroblasts
are one of the first anchorage-dependent cells to arrive at an implant surface during the wound healing process. Persistent
excessive functions of fibroblasts have been linked to detrimental fibrous tissue formation which may cause implant failure.
The IPD process creates a surface-engineered nanostructure (with features usually below 100 nm) by first using a vacuum to
remove all contaminants, then guiding charged metallic ions or plasma to the surface of a medical device at ambient temperature.
Results demonstrated that compared to currently used titanium and uncoated silicone, silicone coated with titanium using IPD
significantly decreased fibroblast adhesion and proliferation. Results also showed competitively increased osteoblast (bone-forming
cells) over fibroblast adhesion on silicone coated with titanium; in contrast, osteoblast adhesion was not competitively increased
over fibroblast adhesion on uncoated silicone or titanium controls. In this manner, this study strongly suggests that IPD
should be further studied for biomaterial applications in which fibrous tissue encapsulation is undesirable (such as for orthopedic
implants, cardiovascular components, etc.). 相似文献
9.
G. W. Storey 《Water research》1987,21(2)
The survival of T. saginata eggs in stored sludge, anaerobic and aerobic mesophilic and thermophilic digesters is examined, particularly with reference to the protection afforded to eggs bound within proglottids. Gross survival times paralleled the results of other workers. However, proglottid bound eggs always survived for longer periods than did freshly dissected eggs. The consequences of this for experimentation is discussed. T. saginata eggs were killed in all treatments with anaerobic digestion being more effective than aerobic digestion and lagooning. In all processes the major controlling factor was temperature; at 35°C eggs were killed faster than at 20°C, eggs at 55°C survived for only a few hours whether free or in proglottids. 相似文献
10.
Barbara P. Atshaves Avery L. McIntosh Stephen M. Storey Kerstin K. Landrock Ann B. Kier Friedhelm Schroeder 《Lipids》2010,45(2):97-110
Since liver fatty acid binding protein (L-FABP) facilitates uptake/oxidation of long-chain fatty acids in cultured transfected
cells and primary hepatocytes, loss of L-FABP was expected to exacerbate weight gain and/or obesity in response to high dietary
fat. Male and female wild-type (WT) and L-FABP gene-ablated mice, pair-fed a defined isocaloric control or high fat diet for
12 weeks, consumed equal amounts of food by weight and kcal. Male WT mice gained weight faster than their female WT counterparts
regardless of diet. L-FABP gene ablation enhanced weight gain more in female than male mice—an effect exacerbated by high
fat diet. Dual emission X-ray absorptiometry revealed high-fat fed male and female WT mice gained mostly fat tissue mass (FTM).
L-FABP gene ablation increased FTM in female, but not male, mice—an effect also exacerbated by high fat diet. Concomitantly,
L-FABP gene ablation decreased serum β-hydroxybutyrate in male and female mice fed the control diet and, even more so, on
the high-fat diet. Thus, L-FABP gene ablation decreased fat oxidation and sensitized all mice to weight gain as whole body
FTM and LTM—with the most gain observed in FTM of control vs high-fat fed female L-FABP null mice. Taken together, these results
indicate loss of L-FABP exacerbates weight gain and/or obesity in response to high dietary fat. 相似文献