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排序方式: 共有255条查询结果,搜索用时 15 毫秒
1.
Dr. Maria L. Di Paolo Dr. Michael S. Christodoulou Dr. Alessandra M. Calogero Dr. Luca Pinzi Prof. Giulio Rastelli Prof. Daniele Passarella Prof. Graziella Cappelletti Prof. Lisa Dalla Via 《ChemMedChem》2019,14(18):1641-1652
A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (Ki) values in the sub-micromolar range and a good selectivity index (Ki MAO-A/Ki MAO-B>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a ) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity. 相似文献
2.
Su M.F. Reda Taha M.M. Christodoulou C.G. El Kady I. 《Photonics Technology Letters, IEEE》2008,20(10):761-763
Processing methods used in photonics and nanotechnology possess many limitations restricting their application areas such as high cost, inability to produce fine details, problems with scalability, and long processing time. Proximity field nanopatterning is a lithography method which surpasses these limitations. By using interference patterns produced by a two-dimensional phase mask, the technique is able to generate a submicron detailed exposure on a millimeter-size slab of light sensitive photopolymer, which is then developed like a photographic plate to reveal three-dimensional interference patterns from the phase mask. While it is possible to use simulations to obtain the interference patterns produced by a phase mask, realizing the mask dimensions necessary for producing a desired interference pattern is analytically challenging due to the intricacies of light interactions involved in producing the final interference pattern. An alternative method is to iteratively optimize the phase mask until the interference patterns obtained converge to the desired pattern. However, depending on the optimization technique used, one either risks a significant probability of failure or requires a prohibitive number of iterations. We argue that an optimization technique that is to take advantage of the physics of the problem using machine learning methods (here fuzzy learning) can lead to competent mask design. This technique is described in this letter. 相似文献
3.
Rovithakis G.A. Christodoulou M.A. 《IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics》1997,27(5):810-822
With this paper we extend our previous work on the subject, by including the case where the number of control inputs is different from the number of states which is frequently faced in control engineering problems. Uniform ultimate boundedness of the state and uniform boundedness of all other signals in the closed loop is guaranteed. Robustness of our algorithm due to the presence of a modeling error term which has linear growth with unknown growth coefficient is also established. Finally, the applicability of our control scheme is highlighted via simulation results. 相似文献
4.
CV Christodoulou DR Ferry DW Fyfe A Young J Doran TM Sheehan A Eliopoulos K Hale J Baumgart G Sass DJ Kerr 《Canadian Metallurgical Quarterly》1998,16(8):2761-2769
PURPOSE: To determine the maximum-tolerated dose (MTD) and the dose-limiting toxicities (DLTs) of a weekly schedule of titanocene dichloride (TD) and to define the pharmacokinetics of titanium in plasma and urine. PATIENTS AND METHODS: Twenty patients with a median age of 58 years received 83 courses of TD. TD was given as 1-hour infusion at escalating doses from 70 to 185 mg/m2/wk. Pharmacokinetic analysis was performed in eight patients for total plasma titanium (TPTi) and in three patients for ultrafiltrable titanium (UFTi). RESULTS: At the fifth dose level (185 mg/m2/wk), a variety of DLTs were seen in five patients: fatigue in three, bilirubinemia in one, and hypokalemia in two. A further six patients were treated at 140 mg/m2; only one had dose-limiting creatinine elevation and this dose was therefore defined as the MTD. No myelosuppression or alopecia were observed. One patient with adenocarcinoma of unknown primary had a minor response. Pharmacokinetic analysis showed that TPTi maximum concentration (Cmax) values were linear with dose and elimination of TPTi was triphasic with a long terminal half-life (t1/2; median, 165 hours; range, 89 to 592). Between 7% and 24.3% of the total of administered titanium was eliminated in urine over the first 24 hours. In contrast, UFTi elimination was described by a one-compartment model with a t1/2 of 0.41 hours; peak levels of UFTi were 5.2% +/- 2.5% those of TPTi. CONCLUSION: The MTD of TD given on a weekly schedule is 140 mg/m2, with cumulative, but reversible creatinine and bilirubin elevation being the DLTs. 相似文献
5.
Boutalis Y. Theodoridis D.C. Christodoulou M.A. 《Neural Networks, IEEE Transactions on》2009,20(4):609-625
The indirect adaptive regulation of unknown nonlinear dynamical systems is considered in this paper. The method is based on a new neuro-fuzzy dynamical system (neuro-FDS) definition, which uses the concept of adaptive fuzzy systems (AFSs) operating in conjunction with high-order neural network functions (FHONNFs). Since the plant is considered unknown, we first propose its approximation by a special form of an FDS and then the fuzzy rules are approximated by appropriate HONNFs. Thus, the identification scheme leads up to a recurrent high-order neural network (RHONN), which however takes into account the fuzzy output partitions of the initial FDS. The proposed scheme does not require a priori experts' information on the number and type of input variable membership functions making it less vulnerable to initial design assumptions. Once the system is identified around an operation point, it is regulated to zero adaptively. Weight updating laws for the involved HONNFs are provided, which guarantee that both the identification error and the system states reach zero exponentially fast, while keeping all signals in the closed loop bounded. The existence of the control signal is always assured by introducing a novel method of parameter hopping, which is incorporated in the weight updating law. Simulations illustrate the potency of the method and comparisons with conventional approaches on benchmarking systems are given. Also, the applicability of the method is tested on a direct current (dc) motor system where it is shown that by following the proposed procedure one can obtain asymptotic regulation. 相似文献
6.
Nima Taghipour Mariona Dalmases Guy L. Whitworth Miguel Dosil Andreas Othonos Sotirios Christodoulou Shanti Maria Liga Gerasimos Konstantatos 《Advanced materials (Deerfield Beach, Fla.)》2023,35(1):2207678
The use of colloidal quantum dots (CQDs) as a gain medium in infrared laser devices has been underpinned by the need for high pumping intensities, very short gain lifetimes, and low gain coefficients. Here, PbS/PbSSe core/alloyed-shell CQDs are employed as an infrared gain medium that results in highly suppressed Auger recombination with a lifetime of 485 ps, lowering the amplified spontaneous emission (ASE) threshold down to 300 µJ cm−2, and showing a record high net modal gain coefficient of 2180 cm−1. By doping these engineered core/shell CQDs up to nearly filling the first excited state, a significant reduction of optical gain threshold is demonstrated, measured by transient absorption, to an average-exciton population-per-dot 〈Nth〉g of 0.45 due to bleaching of the ground state absorption. This in turn have led to a fivefold reduction in ASE threshold at 〈Nth〉ASE = 0.70 excitons-per-dot, associated with a gain lifetime of 280 ps. Finally, these heterostructured QDs are used to achieve near-infrared lasing at 1670 nm at a pump fluences corresponding to sub-single-exciton-per-dot threshold (〈Nth〉Las = 0.87). This work brings infrared CQD lasing thresholds on par to their visible counterparts, and paves the way toward solution-processed infrared laser diodes. 相似文献
7.
In this paper, the issue of efficient power allocation in the uplink of CDMA wireless networks supporting real-time services with various QoS constraints, is addressed. Within the proposed framework, utility functions are adopted to reflect a user’s degree of satisfaction with respect to its actual throughput requirements satisfaction and respective power consumption. The corresponding problem is formulated as a non-cooperative game where users aim selfishly at maximizing their utility-based performance under the imposed limitations. The existence and uniqueness of a Nash equilibrium point of the proposed Uplink Power Control (UPC) game is proven, at which all users have attained a targeted SINR threshold value or transmit with their maximum power, leading essentially to an SINR-balanced system. Moreover, a distributed iterative algorithm for reaching UPC game’s equilibrium is provided. The properties of equilibrium in a pure optimization theoretical framework are studied, and the tradeoffs between users’ overall throughput performance and real-time services’ QoS requirements satisfaction, in channel aware resource allocation processes, are revealed and quantified. Through modeling and simulation the efficacy of the introduced framework and proposed UPC algorithm are demonstrated and evaluated. 相似文献
8.
9.
L. Lawrence Ho David J. Cavuto Symeon Papavassiliou Anthony G. Zawadzki 《Journal of Network and Systems Management》2001,9(2):139-159
Adaptive algorithms for real-time and proactive detection of network/service anomalies, i.e., soft performance degradations, in transaction-oriented wide area networks (WANs) have been developed. These algorithms (i) adaptively sample and aggregate raw transaction records to compute service-class based traffic intensities, in which potential network anomalies are highlighted; (ii) construct dynamic and service-class based performance thresholds for detecting network and service anomalies; and (iii) perform service-class based and real-time network anomaly detection. These anomaly detection algorithms are implemented as a real-time software system called TRISTAN (
ansaction
n
antaneous
nomaly
otification), which is deployed in the AT&T Transaction Access Services (TAS) network. The TAS network is a commercially important, high volume (millions of transactions per day), multiple service classes (tens), hybrid telecom and data WAN that services transaction traffic such as credit card transactions in the US and neighboring countries. TRISTAN is demonstrated to be capable of automatically and adaptively detecting network/service anomalies and correctly identifying the corresponding "guilty" service classes in TAS. TRISTAN can detect network/service faults that elude detection by the traditional alarm-based network monitoring systems. 相似文献
10.
Symeon Nikitidis Anastasios Tefas Nikos Nikolaidis Ioannis Pitas 《Pattern recognition》2012,45(12):4080-4091
Nonnegative Matrix Factorization (NMF) is among the most popular subspace methods, widely used in a variety of image processing problems. Recently, a discriminant NMF method that incorporates Linear Discriminant Analysis inspired criteria has been proposed, which achieves an efficient decomposition of the provided data to its discriminant parts, thus enhancing classification performance. However, this approach possesses certain limitations, since it assumes that the underlying data distribution is unimodal, which is often unrealistic. To remedy this limitation, we regard that data inside each class have a multimodal distribution, thus forming clusters and use criteria inspired by Clustering based Discriminant Analysis. The proposed method incorporates appropriate discriminant constraints in the NMF decomposition cost function in order to address the problem of finding discriminant projections that enhance class separability in the reduced dimensional projection space, while taking into account subclass information. The developed algorithm has been applied for both facial expression and face recognition on three popular databases. Experimental results verified that it successfully identified discriminant facial parts, thus enhancing recognition performance. 相似文献