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排序方式: 共有465条查询结果,搜索用时 31 毫秒
1.
JM Piepmeier DL Keefe MA Weinstein D Yoshida J Zielinski TT Lin Z Chen F Naftolin 《Canadian Metallurgical Quarterly》1993,32(3):422-30; discussion 430-1
Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days. We evaluated human glioblastoma cultures with [3H]thymidine incorporation assays to determine estramustine's early effects on deoxyribonucleic acid synthesis in these tumors. Because estramustine shares a common structural motif with other antimicrotubule drugs, we synthesized four A-ring conjugates of estrone that contained a carbamate moiety but lacked nitrogen mustard. These analogs were examined by [3H]thymidine incorporation and compared with vinblastine. Greater than 70% inhibition of [3H]thymidine incorporation occurred within 1 hour of treatment with estramustine at 10(-5) mol/L, which increased to 80% inhibition at 4 hours. Ethyl carbamate JE208 was nearly as effective as estramustine in inhibiting deoxyribonucleic acid synthesis, and both were more effective than vinblastine. The inhibitory effects of estramustine and estrone analogs were reversible; vinblastine was not reversible. Although estramustine and JE208 induced similar antiproliferative and morphological changes in glioblastoma cells that persisted for at least 4 days, there was a modest recovery of morphology and thymidine incorporation with JE208 after prolonged treatment. The common findings with estramustine and JE208 suggest that these agents may have a similar mechanism of action and form the basis for the investigation of new agents that may rapidly and reversibly inhibit glioblastoma. 相似文献
2.
TT Wu SH Swerdlow J Locker D Bahler P Randhawa EJ Yunis PS Dickman MA Nalesnik 《Canadian Metallurgical Quarterly》1996,27(2):157-164
This paper discusses the problem of violence and its expression upon mortality due to external causes. A few indicators are offered, which have been worked upon it to emphasise the importance of the theme. In a general way, the study demonstrates violent death has had its magnitude increased along the years, not only throughout Latin America but also in Brazil and in Santa Catarina. 相似文献
3.
Arden L. Bement 《Metallurgical and Materials Transactions B》1987,18(1):5-17
The field of materials science and engineering is advancing at a revolutionary pace. It is now generally recognized as being
among the key emerging technological fields propelling our world societies into the twenty-first century. The driving forces
for this revolutionary pace are at once social, economic, political, and technological. For example, relatively recent changes
in United States federal policies in environmental control, hazardous waste management, and energy conservation along with
heightened international trade competition have resulted in major changes in material processing and use patterns. These changing
patterns are creating new requirements for material developments, substitutions, and associated processes. This paper traces
the emergence of materials policy and technological developments through four sub-periods of history: the birth and development
of engineering in the United States (1825–1900), the evolution of a national research infrastructure (1900–1945), the evolution
of a national science policy (1945–1973), and the intensification of global interdependency (1973-present). Future trends
in materials developments and future policy requirements are outlined.
Technical Resources, of TRW, Inc., began his professional career in 1954 as a research metallurgist and reactor project engineer
with General Electric Co. at the Hanford Atomic Products Operation in Richland, WA. In 1965 he joined Battelle Memorial Institute
as a manager of the metallurgy research department and three years later became manager of the fuels and materials department.
In 1970 Dr. Bement joined the faculty of Massachusetts Institute of Technology as professor of nuclear materials. From 1974
to 1976 he served as a member of the U.S.-U.S.S.R. Bilateral Exchange Program in Magnetohydrodynamics and was the organizer
and principal investigator of the M.I.T. Fusion Technology Program. In 1976 Dr. Bement became Director of the Materials Sciences
Office of the Defense Advanced Research Projects Agency and in 1979 was appointed Deputy Under-Secretary of Defense for Research
and Engineering. Dr. Bement has co-authored one book, edited three books, and authored over 90 articles on materials science,
energy, and defense technology. He is a Fellow of the American Nuclear Society, the American Society for Metals, and the American
Institute of Chemists. In addition, he is a member of the American Institute for Mining, Metallurgical and Petroleum Engineers,
and the American Society for Testing and Materials. He has received outstanding achievement awards from the Colorado Engineering
Council in 1954, the Defense Advanced Research Projects Agency in 1977, and the Colorado School of Mines in 1984. In 1980
he was awarded the Distinguished Civilian Service Medal by the Secretary of Defense. He is a member of the National Academy
of Engineering. Dr. Bement is chairman of the National Materials Advisory Board and a member of the Board of Army Science
and Technology, the Board on Engineering Sciences, the Board on Assessment of National Bureau of Standards Programs, and the
Board on Science and Technology for International Development of the National Research Council. Dr. Bement received an Engineer
of Metallurgy (E. Met.) degree in 1954 from the Colorado School of Mines. He received an M.S. in Metallurgical Engineering
from the University of Idaho in 1959, and a Ph.D. from the University of Michigan in 1963. He is a Lt. Colonel (ret.) in the
U.S. Army Corps of Engineers. Dr. Bement and his family reside in Mayfield Village, OH. 相似文献
4.
NI Koval'chuk FN Shubin VA Khoroshko FN Sheverdina TT Tarasenko NG Kosheleva 《Canadian Metallurgical Quarterly》1997,(5):88-91
The results of the comparative study of the phenotypical properties and the plasmid profile of 63 strains of salmonellae, belonging to 44 serotypes of groups B, C1, C2, C3, D, E1, E4, F. The study revealed that strains of different serotypes had their individual plasmid profile. Strains of the same serotype of salmonellae isolated from similar sources had an identical plasmid profile, while strains isolated from different sources differed in their plasmid profiles, though they might have a similar phenotype. Plasmid analysis was shown to be an effective method for the intraspecific typing of rarely isolated Salmonella serotypes and suitable for use as the basis of the microbiological monitoring of salmonellae. 相似文献
5.
MJ Kania SD Keeling SP McGorray TT Wheeler GJ King 《Canadian Metallurgical Quarterly》1996,66(6):423-432
This study examined risk factors associated with incisor injury in 3396 third and fourth grade school children in Alachua County, Florida. One of six orthodontists completed a standardized examination form for each child to assess severity of incisor injury, gender, age, race, skeletal relationships, morphologic malocclusion, incisor exposure, interlabial gap, TMJ sounds, chin trauma, and history of lower facial trauma. One in five (19.2%) exhibited some degree of incisor injury. This was limited to a single tooth in 73.1% of those with injury, while enamel injury predominated (89.4%). The majority of the injuries (75.4%) were localized in the maxillary arch, with central incisors the most frequently traumatized. Chi-square tests of association indicated that gender, race, school, orthodontist, history of lower facial trauma, chin trauma, profile, and maxillary and mandibular horizontal positions were associated with incisor injury (P < 0.05). Wilcoxon rank sum tests identified differences in age, overjet, time of screening, and interlabial gap between those with and without injury (P < 0.05). Results of logistic regression analyses indicated risk of incisor injury was greater for children who had a prognathic maxilla, a history of trauma, were older, were male, and had greater overjet and mandibular anterior spacing. 相似文献
6.
This is a study of the differences in the risk factors for being either hepatitis B surface antigen positive [HBsAg(+)] or antibody to hepatitis C virus positive [Anti-HCV(+)] in A-Lein, a rural area in southern Taiwan, an area which also has a high hepatoma mortality rate. Three hundred eighty-five patients age > or =40 years participated in hepatoma screening at the A-Lein Community Health Center during 1995. Those who were HBsAg(-) and anti-HCV(-) or had coinfection of HBsAg(+) and anti-HCV(+) were excluded, leaving 293 patients: 109 HBsAg(+) and 184 anti-HCV(+). The anti-HCV(+) patients had a lower socioeconomic status (as defined by level of education and type of occupation) and were older than HBsAg(+) patients (P < 0.05). Those with higher alanine aminotransferase levels (ALT) also had a higher anti-HCV(+) to HBsAg(+) odds ratio (OR), and a dose response relationship was found, P < 0.0001. Anti-HCV(+) patients were more likely than HBsAg(+) patients to have a spouse who shared the infection, OR = 5.11; 95% CI, 2.30-11.28. Anti-HCV(+) patients were more likely than HBsAg(+) patients to have had blood transfusions (OR = 2.66; 95% CI, 1.20-5.89), frequent medical injections (OR = 2.64; 95% CI, 1.62-4.31), or injections by non-licensed medical providers (OR = 1.91; 95% CI, 1.18-3.09). Multiple logistic regression analysis showed that the significant factors for anti-HCV(+) patients vs. HBsAg(+) patients are drinking habit (OR = 3.45; 95% CI, 1.02-11.60), age (OR = 6.33; 95% CI, 2.93-13.68), and frequent medical injections (OR = 2.88; 95% CI, 1.65-5.03). The transmission of hepatitis C in A-Lein is closely related to low socioeconomic status, age, alcohol abuse, spouses being anti-HCV(+), and frequent medical injections, especially from non-licensed medical providers, including both pharmacists and those with no medical licensing whatsoever. These nonlicensed medical providers sometimes reuse needles to save money, which is a likely route of infection. 相似文献
7.
Although the good appearance and biocompatibility of dental porcelains, failures are still of considerable concern because of the limited properties to all ceramic system. Physical properties that might be considered ideal include high strength, resistance to abrasion, and resistance to the hostile oral environment. Porcelain has been considered by many of its physical characteristic are similar to those of enamel. In 1983 a new modality of treatment, the etched porcelain restoration was introduced by Simonsen and Calamia. Numerous investigations have shown the strength of the etched porcelain bonded to composite resin and also the clinical success of this porcelain to be used as laminated veneers and etched inlays and onlays. 相似文献
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