Docosahexaenoic acid and traumatic brain injury

Traumatic brain injury (TBI) is becoming increasingly recognised as a major cause of disability, with a significant impact on health costs both in the developed and developing world. At present, there is no effective treatment for this type of acute neurological injury. Docosahexaenoic acid (DHA) is an abundant polyunsaturated fatty acid in the brain, known to have a significant structural role as well as functional roles. Preclinical accumulating evidence indicates that DHA has potential as a restorative therapeutic agent for traumatic brain injury.     

Self-defeating behaviors in organizations: The relationship between thwarted belonging and interpersonal work behaviors.

This multisource field study applied belongingness theory to examine whether thwarted belonging, defined as the perceived discrepancy between one's desired and actual levels of belonging with respect to one's coworkers, predicts interpersonal work behaviors that are self-defeating. Controlling for demographic variables, job type, justice constructs, and trust in organization in a multilevel regression analysis using data from 130 employees of a clinical chemical laboratory and their supervisors, the authors found that employees who perceive greater levels of desired coworker belonging than actual levels of coworker belonging were more likely to engage in interpersonally harmful and less likely to engage in interpersonally helpful behaviors. Implications for the application of belongingness theory to explain self-defeating behaviors in organizations are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

MOSAIC: Declarative platform for dynamic overlay composition

Overlay networks create new networking services using nodes that communicate using pre-existing networks. They are often optimized for specific applications and targeted at niche vertical domains, but lack interoperability with which their functionalities can be shared. Mosaic is a declarative platform for constructing new overlay networks from multiple existing overlays, each possessing a subset of the desired new network’s characteristics.This paper focuses on the design and implementation of Mosaic: composition and deployment of control and/or data plane functions of different overlay networks, dynamic compositions of overlay networks to meet changing application needs and network conditions, and seamless support for legacy applications. Mosaic overlays are specified using Mozlog, a new declarative language for expressing overlay properties independently from their particular implementation or underlying network.Mosaic is validated experimentally using compositions specified in Mozlog in order to create new overlay networks with compositions of their functions: the i3 indirection overlay that supports mobility, the resilient overlay network (RON) overlay for robust routing, and the Chord distributed hash table for scalable lookups. Mosaic uses runtime composition to simultaneously deliver application-aware mobility, NAT traversal and reliability. We further demonstrate Mosaic’s dynamic composition capabilities by Chord switching its underlay from IP to RON at runtime.Mosaic’s benefits are obtained at a low performance cost, as demonstrated by measurements on both a local cluster environment and the PlanetLab global testbed.     

Psychotropic drugs in pregnancy: uses and risks

Recent studies on the recognition of antigens by CD4+ and CD8+ T cells have revealed new ways of preparing efficient T-cell vaccines. Here, Constantin Bona and colleagues discuss several approaches for the development of T-cell vaccines, with applications ranging from the induction of protective immunity against intracellular parasites to the development of therapeutic agents against autoimmune disorders, allergic diseases and cancer.     

Self-gain or self-regulation impairment? Tests of competing explanations of the supervisor abuse and employee deviance relationship through perceptions of distributive justice.

[Correction Notice: An erratum for this article was reported in Vol 95(6) of Journal of Applied Psychology (see record 2010-22091-001). The note to Table 10 on p. 1024 inadvertently referred to PYM as the path from ego depletion to deviant employee behaviors. The note instead should have referred to PYM as the path from intrusive thoughts to deviant employee behaviors.] Two competing explanations for deviant employee responses to supervisor abuse are tested. A self-gain view is compared with a self-regulation impairment view. The self-gain view suggests that distributive justice (DJ) will weaken the abusive supervision–employee deviance relationship, as perceptions of fair rewards offset costs of abuse. Conversely, the self-regulation impairment view suggests that DJ will strengthen the relationship, as experiencing abuse drains self-resources needed to maintain appropriate behavior, and this effect intensifies when employees receive inconsistent information about their organizational membership (fair outcomes). Three field studies using different samples, measures, and designs support the self-regulation impairment view. Two studies found that the Abusive Supervision × DJ interaction was mediated by self-regulation impairment variables (ego depletion and intrusive thoughts). Implications for theory and research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mortality during initial and during later lithium treatment. A collaborative study by the International Group for the Study of Lithium-treated Patients

To study the radioprotective effect of Z-100 against mucositis, twenty-five patients with head and neck malignancies were received external irradiation of 30-61.2 Gy (mean 44.4 Gy) concurrent with Z-100 injection twice a week. Of these cases, an incidence of dysphagia was less than 20% and white coating mucositis below 50%. Frequency of radiation mucositis in these regions was reduced compared to our previous experiences; efficacy of 88%. This combined therapy seems to be a promising method.     

Correction to Thau and Mitchell (2010).

Reports an error in "Self-gain or self-regulation impairment? Tests of competing explanations of the supervisor abuse and employee deviance relationship through perceptions of distributive justice" by Stefan Thau and Marie S. Mitchell (Journal of Applied Psychology, , , np). The note to Table 10 on p. 1024 inadvertently referred to PYM as the path from ego depletion to deviant employee behaviors. The note instead should have referred to PYM as the path from intrusive thoughts to deviant employee behaviors. (The following abstract of the original article appeared in record 2010-16976-001.) Two competing explanations for deviant employee responses to supervisor abuse are tested. A self-gain view is compared with a self-regulation impairment view. The self-gain view suggests that distributive justice (DJ) will weaken the abusive supervision–employee deviance relationship, as perceptions of fair rewards offset costs of abuse. Conversely, the self-regulation impairment view suggests that DJ will strengthen the relationship, as experiencing abuse drains self-resources needed to maintain appropriate behavior, and this effect intensifies when employees receive inconsistent information about their organizational membership (fair outcomes). Three field studies using different samples, measures, and designs support the self-regulation impairment view. Two studies found that the Abusive Supervision × DJ interaction was mediated by self-regulation impairment variables (ego depletion and intrusive thoughts). Implications for theory and research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An extension of uncertainty management theory to the self: The relationship between justice, social comparison orientation, and antisocial work behaviors.

A multisource field study of 103 employees and their supervisors tested an extension of uncertainty management theory (E. A. Lind & K. Van den Bos, 2002; K. Van den Bos & E. A. Lind, 2002). According to this theory, persons high in social comparison orientation (F. X. Gibbons & B. P. Buunk, 1999) experience chronic uncertainty about the self. It was hypothesized that this should strengthen the effects of interactional and procedural justice perceptions on antisocial work behaviors. As predicted, the negative relationship between employee perceptions of interactional justice and supervisory ratings of antisocial work behaviors was stronger for people who are high as compared with low in social comparison orientation. Results provide evidence for an extension of uncertainty management theory to the self-domain. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder

OBJECTIVES: To determine whether readmission to hospital for children aged 1-7 years with asthma can be predicted; and to discover whether factors related to the severity of the attack and past pattern of asthma, assessment of the parents' intention to treat the child with inhaled therapy, perceived consequences of treatment, habits of treatment and self-efficacy show a difference between those children subsequently readmitted and those who were not. METHODS: A specifically developed questionnaire was administered to parents of 121 children admitted with asthma. Clinical assessment was made of severity of the acute attack and past pattern of the asthma. One year after admission subjects were reviewed to determine those who had been readmitted. RESULTS: On univariate analysis, the negative perceived consequences of treatment with inhaled therapy were associated with an increased risk of readmission over a one-year period (P = 0.04). After adjusting for confounders (place of birth of mother, two- or one-parent family) and the effect-modifier of past pattern of the asthma (infrequent episodic, frequent episodic, persistent), the greater the negative perceived consequences of treatment, the more likely there would be readmission in children with infrequent episodic asthma. After adjusting for potential confounders, using logistic regression a decrease of one standard deviation in the negative perceived consequences score resulted in a one-third decrease in the odds of readmission (odds ratio (OR) = 0.31, 95% CI 0.12-0.83). CONCLUSIONS: Parents whose children are readmitted see greater negative perceived consequences of treatment. If asthma is infrequent episodic, the negative perceived consequences may be an inhibitor of treatment, whereas for more severe past patterns of asthma the severity is the controller of treatment. If parental negative consequences could be decreased, admissions for asthma may decrease.