The effects of the pretreatment of intravenous high dose methylprednisolone on Na(+)-K(+)/Mg(+2) ATPase and lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat

The sodium-potassium activated and magnesium dependent adenosine-5'-triphosphatase (Na(+)-K(+)/Mg(+2) ATPase EC.3.6.1.3.) activity and lipid peroxidation and early ultrastructural findings were determined in rat brain at the acute stage of ischaemia produced by permanent unilateral occlusion of the middle cerebral artery (MCA). The effects of the pretreatment with intravenous high-dose methylprednisolone (MP) on these biochemical indices and ultrastructural findings were also evaluated in the same model. The rats were divided into four groups. In group I, 10 rats were used to determine Na(+)-K(+)/Mg(+2) ATPase activity and the extent of lipid peroxidation by measuring the malondialdehyde (MDA) content and normal ultrastructural findings. In group II on 20 rats, only subtemporal craniectomy was done in order to determine the effects of the surgical procedure on these indices and findings. This group was treated intravenously with saline solution before occlusion. In group III with MCA occlusion, saline solution was administered intravenously to 20 rats in the same amount of methylprednisolone used in group IV, ten minutes before the occlusion. In Group IV, a single high-dose (30 mg/kg) of methylprednisolone was administered intravenously, ten minutes before occlusion in 20 rats. After occlusion of the middle cerebral artery, Na(+)-K(+)/Mg(+2) ATPase activity was decreased promptly in the first ten minutes in the ischaemic hemisphere and remained at a lower level than the contralateral hemispheres in the same group and the normal levels in group I, during 120 minutes of ischaemia. A single dose methylprednisolone pretreatment prohibited the inactivation of Na(+)-K(+)/Mg(+2) ATPase. On the other hand, there was significant difference in malondialdehyde content between group I and group III. Malondialdehyde levels were significantly increased following ischaemia and a non-significant increase was observed in the contralateral hemisphere. Methylprednisolone treatment significantly decreased malondialdehyde content on the side of the ischaemic hemisphere. We conclude that there is a positive relationship between membrane-bound enzyme Na(+)-K(+)/Mg(+2) ATPase activity, malondialdehyde content and early ultrastructural changes in the treated group with MP. These data suggest that the pretreatment injection of high doses (30 mg/kg) methylprednisolone contribute to the protection of the brain from ischaemia with stabilization of the cell membrane by effecting the lipid peroxidation and the activation of Na(+)-K(+)/Mg(+2) ATPase.     

综放面采空区遗煤自燃“三带”范围的预测

以峰峰矿区小屯矿14252综放面为研究对象,通过氧化热解实验测定煤样产生的气体成分;利用自制气体采样系统对采空区气体进行采集和分析,进而划分遗煤自燃"三带"范围。结果表明C2H2可作为该综放面煤炭自燃的预测指标,以C2H2浓度划分的采空区遗煤自燃"三带"范围为:散热带0~30m,自燃带30~127m,窒息带大于127m。     

Nodal Superconvergence of SDFEM for Singularly Perturbed Problems

In this paper, we analyze the streamline diffusion finite element method for one dimensional singularly perturbed convection-diffusion-reaction problems. Local error estimates on a subdomain where the solution is smooth are established. We prove that for a special group of exact solutions, the nodal error converges at a superconvergence rate of order (ln ε ⁻¹/N)^2k (or (ln N/N)^2k ) on a Shishkin mesh. Here ε is the singular perturbation parameter and 2N denotes the number of mesh elements. Numerical results illustrating the sharpness of our theoretical findings are displayed.     

葛洲坝500 kV开关站区域稳控装置的建立与应用

针对葛洲坝500kV开关站原有区域稳控装置存在的问题，通过对微机区域稳控装置设计目标、功能和基本控制原理的介绍，展示了一套全新的区域稳控装置：QWD系列区域稳控装置。该系列区域稳控装置已投运，为华中电网综合稳控装置的建立做好了前期的准备。     

Element-by-Element Post-Processing of Discontinuous Galerkin Methods for Timoshenko Beams

In this paper, we consider discontinuous Galerkin approximations to the solution of Timoshenko beam problems and show how to post-process them in an element-by-element fashion to obtain a far better approximation. Indeed, we show numerically that, if polynomials of degree p≥1 are used, the post-processed approximation converges with order 2p+1 in the L ^∞-norm throughout the domain. This has to be contrasted with the fact that before post-processing, the approximation converges with order p+1 only. Moreover, we show that this superconvergence property does not deteriorate as the the thickness of the beam becomes extremely small.Supported in part by NSF Grant DMS-0411254 and by the University of Minnesota Supercomputing Institute.     

省级电力行政交换网软交换改造方案研究

目前省级电力行政交换网大多采用程控交换设备组网,随着程控交换设备的逐步停产和电力系统业务多样化的发展需求,急需进行行政交换网升级改造工作。文章分析了软交换与IMS的商用情况,提出了近期省级电力行政交换网改造的技术体制选择建议、改造原则、建设模式、互联互通方案和下级站点典型接入方案。旨在为近期各省／市行政交换网改造提供方案参考。     

Comparison of sensitivity and specificity of tilt protocols with and without isoproterenol in children with unexplained syncope

Head-up tilt testing with or without isoproterenol is extensively used in the evaluation of patients with unexplained syncope. However, sensitivity and specificity of tilt protocols with and without isoproterenol have not been clarified in children, due to lack of age matched control subjects. This study was designed to assess and to compare the sensitivity and specificity of tilting alone and tilting in conjunction with isoproterenol. Thirty children with unexplained syncope (group I) and 15 age-matched control subjects (control group I) underwent successive 60 degrees head-up tilts for 10 minutes during infusions of 0.02, 0.04, and 0.06 microgram/kg/min of isoproterenol, after a baseline tilt to 60 degrees for 25 minutes. Also, 35 children (group II) with unexplained syncope and 15 healthy control subjects (control group II) were evaluated by head-up tilt to 60 degrees for 45 minutes without an infusion of isoproterenol. In response to tilt protocol with graded isoproterenol, 23 (76.6%) of the patients in group I and 2 of the 15 (13.3%) control subjects developed syncope. Accordingly, the sensitivity of tilt testing with isoproterenol was 76.6%, and its specificity was 86.7%. Tilt testing without isoproterenol was positive in 17 (48.5%) of the patients in group II but in only 1 of the 15 (6.6%) control subjects. Thus, sensitivity and specificity of tilt testing without isoproterenol were 48.5% and 93.4%, respectively. The mean heart rate and systolic blood pressure decreased significantly (P < 0.001) in all tilt positive patients during syncope. In conclusion, the head-up tilt test is a valuable diagnostic test in the evaluation of children with unexplained syncope, and isoproterenol is likely to increase the sensitivity of the test without decreasing its specificity.     

Replacement of aortic root with valved tubular prosthesis in a ten-year-old child with infective endocarditis--a case report

Aortic root abscess, aneurysm of sinus Valsalva, severe aortic valve insufficiency, and a fragile aortic wall caused by infective endocarditis were found in a 10-year-old child. Aortic valve replacement was intended as a preoperative strategy, but one of modifications of Cabrol had to be used urgently because of aortic root rupture between right atrial and aortic connection just after pericardiotomy.