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SB Shustov VKh Khavinson TS Shutak BV Romashevski? 《Canadian Metallurgical Quarterly》1998,76(9):45-48
Epithelamine made in Russia (Samson, St. Petersburg) was tried for effects on carbohydrate metabolism and cardiovascular system in 33 patients with non-insulin-dependent diabetes mellitus (NIDDM). Adjuvant use of epithelamine in combined treatment of NIDDM promoted a stable compensation of carbohydrate metabolism, lowering of glycosylated hemoglobin, immunoreactive insulin. There was also a moderate hypotensive effect and improvement of left ventricular diastolic function. 相似文献
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VG Morozov VKh Khavinson AL Kozhemiakin LA Kozhemiakin 《Canadian Metallurgical Quarterly》1982,28(4):114-118
Thyramine, a polypeptide factor from thymus, at wide range of concentrations increased the cAMP content in rat thymocytes. Increase in the cAMP content was less distinct in spleen lymphoid cells. Thyramine decreased the cGMP content in thymocytes; minimal nucleotide level was found within 15 min of incubation. The data obtained suggest that the rate of lymphocyte maturation is important for response of the cells to the effect of immunoregulating agents. 相似文献
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TA Gudasheva SS Boyko VKh Akparov RU Ostrovskaya SP Skoldinov GG Rozantsev TA Voronina VP Zherdev SB Seredenin 《Canadian Metallurgical Quarterly》1996,391(1-2):149-152
Using high-performance liquid chromatography, gas-chromatography and chromato-mass spectrometry methods a novel endogenous cyclic dipeptide cyclo-prolylglycine was identified in rat brain. Its content according to gas chromatography is 2.8 +/- 0.3 nmol/g wet brain. Synthetic cyclo-prolylglycine has demonstrated antiamnesic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg i.p. Cyclic dipeptide cyclo-prolylglycine seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation. 相似文献
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VP Barkhatova IA Zavalishin LSh Askarova VKh Shavratskii EG Demina 《Canadian Metallurgical Quarterly》1998,28(4):341-344
PURPOSE: The aim of this study was to identify the route of administration of 5-FU with the greatest pharmacological advantage in a rat model using non-invasive in vivo 19F nuclear magnetic resonance (NMR) spectroscopy. METHODS: 5-FU (50 mg/kg) was administered to anesthetized Wistar rats cannulated into the hepatic artery, portal vein or tail vein and 11 NMR spectra were acquired from the liver region to 60.5 min every 5.5 min. RESULTS: With systemic i.v. (tail vein) infusion, the 19F-NMR signal for 5-FU from the liver region peaked in the first spectrum (0-5.5 min), and then gradually decreased. The signal for the 5-FU catabolite alpha-fluoro-beta-alanine (FBAL) gradually increased to the sixth spectrum (0-33.0 min) and then plateaued. Following portal vein infusion the intensity of the first 5-FU spectrum was twice as high as that following i.v. infusion, but the intensity decreased and the FBAL signal increased gradually in the sixth spectrum as systemic i.v. infusion. In contrast, the intensity of the 5-FU signal following hepatic artery infusion was the same as that following portal vein infusion in the first spectrum, and maintained a strong intensity to the final spectrum (60.5 min). The FBAL signal was detected from the second spectrum following hepatic artery infusion, but its intensity was significantly weaker than that following i.v. or portal vein infusion. CONCLUSIONS: Hepatic arterial infusion resulted in the active form of 5-FU being present for a longer time and its degradation in the liver being suppressed compared with the results following portal vein infusion. This catabolic advantage of hepatic arterial infusion could lead to a more potent anti-tumor activity against liver metastases, but could also lead to significant host toxicity including biliary toxicity. We recommend that the dose/schedule of 5-FU administered via the hepatic artery should be adjusted carefully. 相似文献
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EIu El'kind KD Kalantarov VA Kuznetsov RN Turaev VKh Frenkel' 《Canadian Metallurgical Quarterly》1979,(1):50-51
A double-sensor gamma-topograph model GSG-2 has been constructed to realize colour shade lining and black-and-white photographic registration of images reflecting spatial distribution of radioactive isotopes introduced to patients for diagnostic purposes. On the ground of trial tests the valuation of functional and clinical qualities of the device is given. 相似文献
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Abdomino-anal resection of the colon in cancer of its lower ampullar section invading into the anus]
GV Bondar'' VKh Basheev SE Zolotukhin AV Borota GG Psaras 《Canadian Metallurgical Quarterly》1998,97(5):13-15
The special comprehensive multidisciplinary programme for tuberculosis control was used as a basis for planning. The developed special comprehensive interdepartmental programme for tuberculosis control in the region is aimed at involving all services and departments in whom tuberculosis control should be a national, official, professional duty. A multidisciplinary approach to organizing and making antituberculous measures is especially required as antituberculous institutions have the shortest funds now. The programme has approved by the regional administration. 相似文献