Multiuser detection for DS-CDMA UWB in the home environment

We demonstrate the effectiveness of multiuser detection for an ultra-wideband (UWB) pulse based direct sequence spread spectrum system using code division multiple access. Extensive simulations were run using channel soundings of the 2-8 GHz band collected in a residential setting and characterized by a high level of multipath fragmentation. We show that the adaptive minimum mean square error (MMSE) multiuser detection (MUD) receivers are able to gather multipath energy and reject intersymbol and interchip interference for these channels to a much greater extent than RAKE receivers with 4 and 8 arms. We also demonstrate the adaptive MMSE is able to reject a narrowband IEEE 802.11a OFDM interferer, even for signal-to-interference ratio as severe as -30 dB. We show the adaptive MMSE exhibits only a 6 dB penalty relative to the single user case for the heavy multi-access interference (number of asynchronous users equal to spreading code length). The practical RAKE receivers were incapable of effectively rejecting either the strong narrowband interference or the heavily loaded wideband interference. Even more moderate levels of interference caused significant degradation in the performance of the practical RAKE receivers.     

Hyperhomocysteinemia: detection, risk assessment, and treatment

OBJECTIVE: The aim of this study was to evaluate both the importance of the screening strategy and the familial aggregation characteristics of families with hypercholesterolemic children. PATIENTS AND METHODS: Ninety-one families (369 subjects) with one hypercholesterolemic child were studied. In addition to clinical and general biochemical evaluation, lipids including apo A-I and B-100 were examined. LDL was quantified under ultracentrifugation. RESULTS: Among the 91 children studied, 10 (10.99%) suffered heterozygous hypercholesterolemia, while 81 (89.01%) suffered polygenic hypercholesterolemia. Following a diet, polygenic children exhibited normal lipid parameters. In heterozygous children a decrease of 19% for total cholesterol, 19.9% for LDL-cholesterol and 16.3% for apo B were observed. When starting the study, 77.5% of the family members thought that they had normal serum lipid values. At the end of the study it was confirmed that only 28% were really normolipemic, indicating that 49.4% of the individual did not know that they were suffering dyslipemia. The study also showed that fathers exhibited the highest incidence of hypercholesterolemia (80.2%) followed by brothers (65.6%) and mothers (61.5%). Therefore, 69.4% of the individuals studied exhibited dyslipemia. CONCLUSIONS: The screening strategy allows one to diagnose a high percentage (almost 50%) of individuals suffering hypercholesterolemia in families with a child previously diagnosed of this pathology. Moreover, in these families there is a high degree of familiar aggregation of dyslipemia.     

Chances of cure are not compromised with sphincter-saving procedures for cancer of the lower third of the rectum

BACKGROUND: The goal of this study was to compare patterns of recurrence and long-term outcome after sphincter-saving procedures (SSPs) and abdominoperineal resection (APR) in patients with tumors located in the lower third of the rectum. METHODS: We reviewed the charts of 1001 patients operated on for primary rectal adenocarcinoma between 1980 and 1991. All patients with tumors located between 5 and 7 cm from the anal verge and treated with curative intent were included. RESULTS: Of the 261 patients who met our criteria, 162 had undergone SSP and 99 had undergone APR. The local recurrence rates for SSP and APR were 8% and 11%, respectively (p = 0.41), and the distant metastases rates were 23% and 28%, respectively (p = 0.35). Recurrence and distant metastases rates for SSP and APR, respectively, did not differ by TNM classification: state I, 10% versus 9% (p = 0.9); stage II, 25% versus 43% (p = 0.13); and stage III, 56% versus 57% (p = 0.92). Five-year disease-free survival rates for SSP and APR patients were 70.5% and 62.3%, respectively (p = 0.2). CONCLUSIONS: Tumors in the lower third of the rectum can be treated with sphincter-saving procedures without compromising the chance of cure.     

The role of urodynamics in the evaluation of voiding dysfunction in men after cerebrovascular accident

PURPOSE: The etiology of voiding dysfunction was determined in men after a cerebrovascular accident who were at risk for obstructive uropathy to evaluate whether the cause of voiding dysfunction could be predicted by the type (obstructive or irritative) or onset of symptoms. MATERIALS AND METHODS: We evaluated 38 men with complaints of voiding dysfunction following a cerebrovascular accident. All patients were of the age when bladder outlet obstruction secondary to benign prostatic hyperplasia would otherwise be prevalent. After a comprehensive history and physical examination, all patients underwent multichannel urodynamic studies at a medium fill rate (20 to 50 ml. per minute). Findings were classified by the Abrams-Griffiths nomogram as obstruction, no obstruction or equivocal. RESULTS: Mean patient age was 70 years (range 54 to 87). Patients were grouped according to the presenting voiding complaints (purely irritative in 42%, purely obstructive in 34% or mixed in 24%). In 34 patients (89%) the onset of symptoms paralleled the occurrence of the cerebrovascular accident. Detrusor hyperreflexia was noted in 82% of the patients. There was no statistically significant difference in the occurrence of detrusor hyperreflexia among the 3 symptom groups (Fisher's exact test). Pressure-flow analysis clearly showed obstruction in 24 patients (63%), no obstruction in 9 (24%) and equivocal results in 5 (13%) according to the nomogram. There was no statistically significant difference in the incidence of obstruction among the 3 symptom groups (Fisher's exact test). CONCLUSIONS: Presenting symptoms did not predict the urodynamic findings of bladder outlet obstruction or detrusor hyperreflexia. The significant incidence of onset of symptoms after stroke suggests that the cerebrovascular accident induced voiding dysfunction in the face of preexisting bladder outlet obstruction may exacerbate the symptoms of the latter condition or vice versa.     

Effects of laser phase drift on coherent optical CDMA

Code division multiple access (CDMA) has been proposed for use in fiber high speed point-to-point systems. Previous research into CDMA has centered on completely coherent detection, that is, when the phases of all users in the system are known or tracked. While coherent detection is a reasonable assumption in many radio frequency systems, semiconductor lasers suffer from serious phase variation that makes tracking of all phases difficult to accomplish. This paper examines the effects of phase drift on several multiuser detectors for binary phase shift keying (BPSK), as well as two detectors for binary frequency shift keying (BFSK). It is shown that when the desired user's phase can be tracked, BPSK match filtering offers better bit error rates than BFSK, and closed form solutions for the asymptotic error probabilities are derived. When there is no phase tracking, it is shown that the probability of error of the multiuser detectors approaches one half. The analysis is based on a proof of the asymptotic normality of the interference caused by even a single undesired user. All asymptotic results are for infinitely long spreading codes that can be modeled as a random sequence of plus and minus ones. Whether or not the desired user's phase is tracked, all receivers examined suffer from the near-far problem     

Moment-method analysis of large, axially symmetric reflectorantennas using entire-domain functions

The moment-method technique utilizing entire domain basis functions is applied to the analysis of large, axially symmetric reflector antennas. The electric surface current is modeled as a finite series of sinusoids whose domain consists of the entire generating curve. This expansion results in a matrix size of less than 5% of that produced with subdomain basis functions. Only a slight increase in the CPU requirements occurs from this analysis. The results from this technique show good agreement when compared to both physical optics and a subdomain-based moment-method formulation on small, axially fed paraboloidal and hyperboloidal reflector antennas. Extension to a large 100-λ paraboloidal reflector with f/D=0.4 produces results comparable to that obtained using physical optics. Convergence is obtained with as few as two expansion terms per wavelength. Discretization of the generating curve with four points per wavelength leads to results which agree within 0.5 dB over data from a more densely defined curve     

Mapping the active sites of 3-phosphoglycerate kinase and glycerol kinase with monoammine chromium(III) ATP

The 12 isomers of monoammine chromium(III) ATP have been used to probe the ATP binding sites of yeast 3-phosphoglycerate kinase and glycerol kinase from Candida mycoderma. Inhibition studies of 3-phosphoglycerate kinase show a dramatic decrease in isomer binding only when the ammonia is in the Delta axial facial anti position. This suggests an open site architecture with only one strong contact point between the coordination sphere and the enzyme surface. These results agree well with the computer modeling studies of bidentate chromium ATP into the nucleotide site determined by X-ray crystallography [McPhillips, T., et al. (1996) Biochemistry 35, 4118-4127]. Both methods describe an open site strongly supporting the validity of the inhibition studies. Inhibition studies of glycerol kinase show significant decreases in binding for all the tested ammonia positions, suggesting a closed site architecture with many contacts between the coordination sphere and the surface of the enzyme. This is in good agreement with X-ray studies [Hurley, T., et al. (1993) Science 259, 673-677] on the Escherichia coli glycerol kinase. Inhibition studies of hexokinase previously reported [Rawlings, J., et al. (1993) Biochemistry 32, 11204-11210] more closely resemble those of 3-phosphoglycerate kinase, suggesting the surprising result that however closely hexokinase and glycerol kinase are related structurally the site around the coordination sphere in hexokinase is functionally open like that of 3-phosphoglycerate kinase.