Effect of 100 KeV Ar+ ion beam irradiation on ZnO thin films – Influence of morphology vis-a-vis electrode/electrolyte interface and its impact on photoelectrochemical water splitting

The present study attempts quantitative determination of changes in the morphological surface features viz. fractal dimension, lower and upper cut off length scale through Power Spectral Density analysis prior to and after irradiation of 100 KeV Ar⁺ ion beam at incidence angles of 0°, 40° and 60° on ZnO thin films. All the unirradiated and irradiated samples are subjected to photoelectrochemical characterization and a correlation between photoelectrochemical performance and morphological parameters is established. Sample irradiated at 40° angle at the fluence of 5 × 10¹⁶ ions/cm² is found to possess maximum fractal dimension of 2.72, lower and upper cut off length scale of 3.16 nm and 63.00 nm respectively. This sample exhibits maximum photocurrent density of 3.19 mA/cm² and applied bias photon-to-current efficiency of 1.12% at 1.23 V/RHE. Hydrogen gas collected for duration of 1 h for the same sample was ~4.83 mLcm^?2.     

Age-dependent variations in the sexual preference of male rats

Male rats were tested for their sexual preference behavior at either 37, 70, 90, or 150 days of age on three different occasions; while still sexually naive, after sexual experience with a receptive female, and while sexually aroused by having initiated copulation. These tests resulted in the following findings: a) 37-day-old sexually naive males showed a preference for other males and failed to show a preference for either sex after exposure to females; b) 70- and 90-day-old males showed a statistically significant preference for the female after acquiring sexual experience; c) 150-day-old animals showed a female-oriented preference only after being sexually aroused with two intromissions preceding the preference test, and d) none of the age groups tested showed a female-oriented preference without previous exposure to females. It was then concluded that a) female-oriented behavior requires sexual experience and b) the effects of experience varies with age.     

Impact of QOS requirements on video coding for ATM networks

The broadband integrated services digital networks (B-ISDN) based on asynchronous transfer mode (ATM) technology can support a wide range of applications such as voice, video, still images, and data. Compression techniques increase the effective bandwidth utilization, but the bursty and asynchronous nature of the traffic can still lead to congestion in the network, and degradation of image quality and quality of service (QOS). Some of the features to provide better coding schemes for ATM networks are layered coding, resynchronization, buffering, interleaved schemes, constrained bit rate due to buffers, encapsulation with the RTP or AAL1 for clock recovery, lapped transforms, motion compensation, and optimal bit allocation for coders based on wavelet transforms. We review various techniques forimage and video coding such as transforms, motion compensation, vector quantization, and subband coding. We outline the impact of the cell loss ratio (CLR), delay and cell delay variation (CDV) on video coding: blocking effects, loss of frame synchronization, motion vectors, and vector quantization codewords. The open problems include tuning coding parameters to the available QOS provided by the network.     

Scalable P2P bot detection system based on network data stream

P2P Botnets are one of the most malevolent threats to the Internet users due to their resiliency against takedown efforts. In this paper, we propose a bot detection system that is capable of detecting stealthy bots in a network. This system treats network traffic as a data stream, segregating the traffic into two parallel streams. The detection is based on failure traffic and communication traffic. The traffic is analyzed during small time window, and the infected hosts are reported immediately. The network administrator can monitor the status of hosts in the network and can take the necessary action before the infected hosts harm the system or can involve in the attacks. Experiments and evaluation of the proposed system on a variety of P2P data transfer applications and P2P botnets have demonstrated high accuracy of detection. The scalability of the proposed system is exhibited through its implementation on Hadoop MapReduce.     

Rational Filters for Passive Depth from Defocus

A fundamental problem in depth from defocus is the measurement of relative defocus between images. The performance of previously proposed focus operators are inevitably sensitive to the frequency spectra of local scene textures. As a result, focus operators such as the Laplacian of Gaussian result in poor depth estimates. An alternative is to use large filter banks that densely sample the frequency space. Though this approach can result in better depth accuracy, it sacrifices the computational efficiency that depth from defocus offers over stereo and structure from motion. We propose a class of broadband operators that, when used together, provide invariance to scene texture and produce accurate and dense depth maps. Since the operators are broadband, a small number of them are sufficient for depth estimation of scenes with complex textural properties. In addition, a depth confidence measure is derived that can be computed from the outputs of the operators. This confidence measure permits further refinement of computed depth maps. Experiments are conducted on both synthetic and real scenes to evaluate the performance of the proposed operators. The depth detection gain error is less than 1%, irrespective of texture frequency. Depth accuracy is found to be 0.51.2% of the distance of the object from the imaging optics.     

Parametric Feature Detection

Most visual features are parametric in nature, including, edges, lines, corners, and junctions. We propose an algorithm to automatically construct detectors for arbitrary parametric features. To maximize robustness we use realistic multi-parameter feature models and incorporate optical and sensing effects. Each feature is represented as a densely sampled parametric manifold in a low dimensional subspace of a Hilbert space. During detection, the vector of intensity values in a window about each pixel in the image is projected into the subspace. If the projection lies sufficiently close to the feature manifold, the feature is detected and the location of the closest manifold point yields the feature parameters. The concepts of parameter reduction by normalization, dimension reduction, pattern rejection, and heuristic search are all employed to achieve the required efficiency. Detectors have been constructed for five features, namely, step edge (five parameters), roof edge (five parameters), line (six parameters), corner (five parameters), and circular disc (six parameters). The results of detailed experiments are presented which demonstrate the robustness of feature detection and the accuracy of parameter estimation.     

Stereo and Specular Reflection

The problem of accurate depth estimation using stereo in the presence of specular reflection is addressed. Specular reflection, a fundamental and ubiquitous reflection mechanism, is viewpoint dependent and can cause large intensity differences at corresponding points, resulting in significant depth errors. We analyze the physics of specular reflection and the geometry of stereopsis which lead to a relationship between stereo vergence, surface roughness, and the likelihood of a correct match. Given a lower bound on surface roughness, an optimal binocular stereo configuration can be determined which maximizes precision in depth estimation despite specular reflection. However, surface roughness is difficult to estimate in unstructured environments. Therefore, trinocular configurations, independent of surface roughness are determined such that at each scene point visible to all sensors, at least one stereo pair can produce correct depth. We have developed a simple algorithm to reconstruct depth from the multiple stereo pairs.     

Augmented photoelectrochemical response of CdS/ZnS quantum dots sensitized hematite photoelectrode

A visible light active and stable photoelectrode has been developed by depositing a passivating layer of ZnS QDs on CdS QDs sensitized hematite photoelectrode (Hematite‐CdS/ZnS) for PEC generation of hydrogen. Photoelectrochemical properties, in terms of stability and efficiency, have been investigated on the various hematite photoelectrodes sensitized with CdS QDs and CdS/ZnS QDs by varying number of SILAR cycles. I–V characteristics show that two layers of ZnS QDs deposited over three layers of CdS could enhance PEC response of hematite and efficiency by a factor of 3 and 11 respectively. Chronoamperometry measurement ensures that after adding a layer of ZnS QDs, CdS sensitized hematite film turns out to be a stable photoelectrode in the electrolyte. Prepared photoelectrodes have been characterized by XRD, SEM, HRTEM and UV–Vis spectrophotometer for various structural, morphological and optical properties to analyze PEC results. Mott–Schottky analysis and incident photon to current conversion efficiency (IPCE) measurements of sensitized hematite photoelectrode supported the improved PEC response of CdS/ZnS QDs sensitized hematite thin films. Copyright © 2016 John Wiley & Sons, Ltd.     

A thiol‐ene clickable hyperbranched polyester via a simple single‐step melt trans‐esterification process

Self‐condensation of AB₂ type monomers (containing one A‐type and two B‐type functional groups) generates hyperbranched (HB) polymers that carry numerous B ‐type end‐groups at their molecular periphery; thus, development of synthetic methods that directly provide quantitatively transformable peripheral B groups would be of immense value as this would provide easy access to multiply functionalized HB systems. A readily accessible AB₂ monomer, namely diallyl, 5‐(4‐hydroxybutoxy)isophthalate was synthesized, which on polymerization under standard melt‐transesterfication conditions yielded a peripherally clickable HB polyester in a single step; the allyl groups were quantitatively reacted with a variety of thiols using the facile photoinitiated “thiol‐ene” reaction to generate a wide range of derivatives, with varying solubility and thermal properties. Furthermore, it is shown that the peripheral allyl double bonds can also be readily epoxidized using meta‐chloroperoxybenzoic acid to yield interesting HB systems, which could potentially serve as a multifunctional cross‐linking agent in epoxy formulations. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40248.     

THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors

Multiple myeloma (MM) is a hematological disease marked by abnormal growth of B cells in bone marrow. Inherent chromosomal instability and DNA damage are major hallmarks of MM, which implicates an aberrant DNA repair mechanism. Studies have implicated a role for CDK12 in the control of expression of DNA damage response genes. In this study, we examined the effect of a small molecule inhibitor of CDK12–THZ531 on MM cells. Treatment of MM cells with THZ531 led to heightened cell death accompanied by an extensive effect on gene expression changes. In particular, we observed downregulation of genes involved in DNA repair pathways. With this insight, we extended our study to identify synthetic lethal mechanisms that could be exploited for the treatment of MM cells. Combination of THZ531 with either DNA-PK inhibitor (KU-0060648) or PARP inhibitor (Olaparib) led to synergistic cell death. In addition, combination treatment of THZ531 with Olaparib significantly reduced tumor burden in animal models. Our findings suggest that using a CDK12 inhibitor in combination with other DNA repair inhibitors may establish an effective therapeutic regimen to benefit myeloma patients.