Enzymatic esterification of glycerol III. Lipase-catalyzed synthesis of regioisomerically pure 1,3-sn-diacylglycerols and 1 (3)-rac-monoacylglycerols derived from unsaturated fatty acids

Lipases that display high regioselectivities and broad substrate tolerance were used as catalysts for the efficient esterification of glycerol under the conditions of irreversible acyl transfer. A variety of unsaturated fatty acids, such as oleic, linoleic, erucic, ricinolic, hydroxystearic and coriolic acid, were used for this purpose in the form of their vinyl esters. Suitable biocatalysts were chosen on the basis of systematic screening experiments regarding their regioselectivities (RE) and substrate tolerances. Distinct differences were found and expressed in numerical RE values as a measure for differences of these biocatalysts as being specific, selective, and nonspecific. Based on these experiments, a variety of molecules were synthesized on a preparative scale (>150 mmol) in good yield (ca.85%) and with high regioisomerical purities (>95% RE).     

The Value of Pooling "Naive" Expertise: Comment.

Comments on the article by D. Westen and J. Weinberger (see record 2004-19091-002), which explored the benefits and limitations of clinical observation and judgment. Westen and Weinberger identify two categories of informants--clinicians and participants--but these categories could be expanded to include other observers who might have particular expertise or experience related to the phenomenon of interest. The type of expert best suited to provide observations depends on the type of expertise required. There are some domains, however, in which those with the greatest expertise are neither specially trained observers nor self-reporters but, rather, lay observers who have a native or learned ability to detect complicated social or psychological phenomena and make subtle discriminations. This type of expertise is often thought of as intuitive because it uses implicit knowledge that is not always accessible to conscious awareness or capable of being fully articulated. One way to harness this intuitive expertise effectively is to pool the judgments of multiple lay observers. Our research has led us to believe that lay observers' intuitive judgments about emotions may in fact capture important information that is lost when coders depend on more commonly used manualized approaches such as the Specific Affect Coding System (SPAFF; Gottman, McCoy, Coan, & Collier, 1996) and the Facial Action Coding System (Ekman & Friesen, 1978). In our zealousness to reduce variability among coders and to make our methods more exportable to other investigators, researchers risk losing the intuitive expertise that people naturally develop in making judgments about the world. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system

OBJECTIVE: To analyze the causes of therapeutic success and failure in the management of patients with high-risk gestational trophoblastic tumors (GTTs). STUDY DESIGN: Analysis of 272 consecutive high-risk patients treated at the trophoblastic disease center at the Charing Cross Hospital between 1979 and 1995. RESULTS: EMA (etoposide, methotrexate, actinomycin D)/CO (cyclophosphamide, vincristine) chemotherapy is our treatment of choice for patients with high-risk GTT. In 272 consecutive patients the cumulative five-year survival was 86.2% (95% confidence interval, 81.9-90.5%). No deaths occurred from GTT more than two years after the start of treatment. In patients whose disease became resistant to EMA/CO or relapsed after receiving EMA/CO, the majority (70%) could be salvaged with further chemotherapy (usually with the EP (etoposide, cisplatin)/EMA chemotherapy with or without surgery. Multivariate analysis identified the following adverse prognostic factors: presence of liver metastases (P < .0001), prolonged interval from antecedent pregnancy (P < .0001), presence of brain metastases (P = .0008) and term delivery of antecedent pregnancy (P = .045). Intensive chemotherapy for treating high-risk GTT carries a small risk of inducing second malignancies, and two patients developed acute myeloid leukemia, 2 cervical malignancy and 1 gastric adenocarcinoma after receiving EMA/CO chemotherapy. CONCLUSION: EMA/CO is an effective and well-tolerated regimen for high-risk GTT. Salvage chemotherapy with EP/EMA is effective in the majority of patients whose disease is resistant to EMA/CO and should be combined with surgery when the dominant site of resistant disease is known. Major adverse prognostic variables have been identified, and patients with combinations of these factors should be considered for innovative therapeutic approaches from the outset.     

What's love got to do with it? Social functioning, perceived health, and daily happiness in married octogenarians.

This study examined day-to-day links between perceived health and happiness and between time spent with others and happiness in 47 older adult couples over an 8-day period. Marital satisfaction and time spent with others were explored as potential moderators of links between health and happiness. For both men and women, hierarchical linear modeling revealed daily links between more time spent with others and greater happiness. Daily links between time spent with one's partner and happiness were strongly moderated by marital satisfaction. For both men and women, marital satisfaction buffered day-to-day links between poorer perceived health and a decline in happiness, but time spent with others did not. This study provides support for the role of marital satisfaction in protecting older adults' happiness from daily fluctuations in perceived physical health and for the influence of social connections in promoting happiness in the lives of older adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reasoning about programs

This paper describes a theorem prover that embodies knowledge about programming constructs, such as numbers, arrays, lists, and expressions. The program can reason about these concepts and is used as part of a program verification system that uses the Floyd-Naur explication of program semantics. It is implemented in the qa4 language; the qa4 system allows many pieces of strategic knowledge, each expressed as a small program, to be coordinated so that a program stands forward when it is relevant to the problem at hand. The language allows clear, concise representation of this sort of knowledge. The qa4 system also has special facilities for dealing with commutative functions, ordering relations, and equivalence relations; these features are heavily used in this deductive system. The program interrogates the user and asks his advice in the course of a proof. Verifications have been found for Hoare's FIND program, a real-number division algorithm, and some sort programs, as well as for many simpler algorithms. Additional theorems have been proved about a pattern matcher and a version of Robinson's unification algorithm. The appendix contains a complete, annotated listing of the deductive system and annotated traces of several of the deductions performed by the system.     

Linking hearts and minds in couple interactions: Intentions, attributions, and overriding sentiments.

This study examined the role of emotion and relationship satisfaction in shaping attributions about a partner's intentions in couple interactions. Using video recall, participants (N = 156 couples) reported on their own and their partner's intentions and emotions during affective moments of a discussion about an upsetting event. Links were found between relationship satisfaction and factor-analytically derived intention and attribution scales. Attributions about a partner's intentions were weakly to moderately correlated with the partner's self-reported intentions. Relationship satisfaction accounted for part of the discrepancy between self-reported intentions and partner attributions. Emotions mediated the links between relationship satisfaction and attributions, suggesting that clinicians working with distressed couples should pay more attention to the emotional climate in which attributions are made. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fundamentals of deductive program synthesis

An informal tutorial for program synthesis is presented, with an emphasis on deductive methods. According to this approach, to construct a program meeting a given specification, the authors prove the existence of an object meeting the specified conditions. The proof is restricted to be sufficiently constructive, in the sense that, in establishing the existence of the desired output, the proof is forced to indicate a computational method for finding it. That method becomes the basis for a program that can be extracted from the proof. The exposition is based on the deductive-tableau system, a theorem-proving framework particularly suitable for program synthesis. The system includes a nonclausal resolution rule, facilities for reasoning about equality, and a well-founded induction rule     

Prospective associations from family-of-origin interactions to adult marital interactions and relationship adjustment.

To test the social learning-based hypothesis that marital conflict resolution patterns are learned in the family of origin, longitudinal, observational data were used to assess prospective associations between family conflict interaction patterns during adolescence and offspring's later marital conflict interaction patterns. At age 14 years, 47 participants completed an observed family conflict resolution task with their parents. In a subsequent assessment 17 years later, the participants completed measures of marital adjustment and an observed marital conflict interaction task with their spouse. As predicted, levels of hostility and positive engagement expressed by parents and adolescents during family interactions were prospectively linked with levels of hostility and positive engagement expressed by offspring and their spouses during marital interactions. Family-of-origin hostility was a particularly robust predictor of marital interaction behaviors; it predicted later marital hostility and negatively predicted positive engagement, controlling for psychopathology and family-of-origin positive engagement. For men, family-of-origin hostility also predicted poorer marital adjustment, an effect that was mediated through hostility in marital interactions. These findings suggest a long-lasting influence of family communication patterns, particularly hostility, on offspring's intimate communication and relationship functioning. (PsycINFO Database Record (c) 2010 APA, all rights reserved)