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Raffael Ott Xenia Pawlow Andreas Weiß Anna Hofelich Melanie Herbst Nadine Hummel Cornelia Prehn Jerzy Adamski Werner Rmisch-Margl Gabi Kastenmüller Anette-G. Ziegler Sandra Hummel 《International journal of molecular sciences》2020,21(24)
Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-child transmission of adverse metabolic health. This study aimed to investigate whether mothers with gestational diabetes mellitus (GDM) and their offspring show similar metabolomic patterns several years postpartum. Targeted metabolomics (including 137 metabolites) was performed in plasma samples obtained during an oral glucose tolerance test from 48 mothers with GDM and their offspring at a cross-sectional study visit 8 years after delivery. Partial Pearson’s correlations between the area under the curve (AUC) of maternal and offspring metabolites were calculated, yielding so-called Gaussian graphical models. Spearman’s correlations were applied to investigate correlations of body mass index (BMI), Matsuda insulin sensitivity index (ISI-M), dietary intake, and physical activity between generations, and correlations of metabolite AUCs with lifestyle variables. This study revealed that BMI, ISI-M, and the AUC of six metabolites (carnitine, taurine, proline, SM(-OH) C14:1, creatinine, and PC ae C34:3) were significantly correlated between mothers and offspring several years postpartum. Intergenerational metabolite correlations were independent of shared BMI, ISI-M, age, sex, and all other metabolites. Furthermore, creatinine was correlated with physical activity in mothers. This study suggests that there is long-term metabolic programming in the offspring of mothers with GDM and informs us about targets that could be addressed by future intervention studies. 相似文献
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Werner Hüning 《化学,工程师,技术》1985,57(10):850-857
Safety measures in thermal waste air purification units . Safety problems may arise in thermal waste air purification units from the occasional explosive nature of the exhaust gases, which may cause a flashback into the production plant. This must be avoided by the installation of safety devices that arrest a flashback. The number of such safety devices is determined by the probability of formation of explosive waste air, according to the zone classification of the explosion-protection guide. The principal explosion arrestor devices installed between combustion chamber and production plant are liquid submersion systems, detonation barriers, and dynamic flashback-free inlets into the combustion chamber, all of which must be operated under instrumental surveillance. This report presents a state-of-the-art summary of all suitable procedures and safety devices permitting safe design of systems for thermal air cleaning problems encountered in practice. 相似文献
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Werner Baltes Gloria Bochmann 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1987,184(3):179-186
Summary From model roastings of mixtures containing serine, threonine and sucrose about 350 volatile compounds were separated and identified by GC/MS. Among them there were more than 100 monocyclic furans, 13 furanones and 8 bicyclic furans, the mass spectra and retention indices of which are recorded. The most important mass spectrometric fragmentation pathways are described. Spectra obtained from roasting coffee under identical conditions are compared with the spectra from model roastings.
Dissertation Gloria Bochmann, TU Berlin 1984 相似文献
Modell-Reaktionen zur Röstaroma-BildungII. Die massenspektrometrische Identifizierung von Furanen und Furanonen aus der Reaktion von Serin und Threonin mit Saccharose unter den Bedingungen der Kaffeeröstung
Zusammenfassung Aus Modellröstungen von Gemischen aus Serin, Threonin und Saccharose unter den Bedingungen der Kaffeeröstung wurden etwa 350 flüchtige Verbindungen mittels GC/MS getrennt und identifiziert. Unter ihnen befanden sich über 100 monocyclische Furane und 13 Furanone sowie 8 bicyclische Furane, deren Massenspektren und Retentions-indices angegeben werden. Die wichtigsten massenspektrometrischen Fragmentierungswege werden beschrieben. -Die aus einer gleich behandelten Röstung von Rohkaffee erhaltenen Spektren werden mit denen der Modellröstungen verglichen.
Dissertation Gloria Bochmann, TU Berlin 1984 相似文献
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Growth of one spherulite within a thin foil of polypropylene around one circular obstacle or around combinations of circular obstacles is investigated. For each obstacle there exists a region of shadow, seen from the nucleus of the spherulite, which influences the growth of the spherulite. Within any region of shadow the growth fronts are evolvents of the obstacle's boundary, because the spherulite grows isotropically. When two growth fronts belonging to one spherulite meet each other inside the shadow, an intrinsic grain boundary is formed for each obstacle. Additionally, growth of one spherulite around a rectangular obstacle and a spherical obstacle is investigated. 相似文献
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On a phenomenon of the limitation of pitting corrosion at high alloyed special stainless steels and NiCrMo-alloys in chloride solutions Testing the pitting corrosion resistance of high alloyed special stainless steels and NiCrMo-alloys in chloride solutions there was observed a limitation of the pitting corrosion range toward more positive potentials. Above this limitation, the so-called pitting corrosion limitation potential, the pit initiation by all means is prevented, but the growth of pits which had been initiated before in the pitting corrosion range not necessarily comes to a stop. Therefore current density-potential curves which are obtained by downward polarization after an initial potential jump into the transpassive region and chronopotentiostatic tests are more suitable to investigate this phenomenon than cyclic polarization measurements and potentiostatic alteration tests. There is indicated a dependence of this phenomenon on temperature. The phenomenon of a limitation of the pitting corrosion range toward more positive potentials has been found until now at alloy 926, alloy 31, alloy 28, alloy 59 and alloy C-276. 相似文献
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Werner Schwiering 《电子设计技术》2006,13(12):105-105
较老式的计算机系统通过4根75Ω同轴电缆把RGB(三原色)视频和复合同步信号输送到150英尺外的RGB彩色监视器。如需升级,用于替换的VGA视频卡可直接驱动VGA监视器的内部端接部件带来的75Ω负载。但是,VGA标准使用单独的水平和垂直正向同步信号。向原始电缆添加一根额外的同轴电缆来承载单独的同步信号,这是一种困难并且成本很高的建议。一个明显的解决方案就是把单独的同步信号组合到一种复合格式中。图1中的组合器电路很简单,成本很低,并且可用随时供货的备件来迅速组装。 相似文献