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排序方式: 共有102条查询结果,搜索用时 15 毫秒
1.
BACKGROUND/PURPOSE: Recent reports have identified abnormal innervation of the circular muscle layer involving the fine intramuscular nerve fibers in hypertrophic pyloric stenous (HPS). HPS presenting after 3 months of age is rare. The aim of this study was to determine the distribution pattern of nerve fibers in the smooth muscle layers in HPS and correlate this with age at presentation. METHODS: Full-thickness pyloric muscle biopsy specimens were obtained from eight patients with HPS (five age 3 to 5 weeks, two age 3 months, and one age 7 months) and five controls with normal pylorus (age 5 days to 3 years). All specimens were stained with monoclonal antibody to the neural cell adhesion molecule (NCAM) using immunohistochemistry. RESULTS: There were many NCAM-positive nerve fibers in the circular and longitudinal muscle layers in the controls. No NCAM positive nerve fibers were seen in the circular or longitudinal muscle layers in the five cases of HPS in which the patients were less than 5 weeks old. In the two cases in which the patients were 3 months old, occasional NCAM-positive nerve fibers were seen in the circular layer, and moderate numbers of NCAM positive fibers were seen in the longitudinal muscle layers. Moderate numbers of NCAM-positive nerve fibers in the circular muscle layer and many NCAM positive nerve fibers in the longitudinal muscle layers were identified in the 7-month-old HPS patient. CONCLUSIONS: The data suggest that the pyloric muscle lacks innervation in the young HPS infant. Whereas, at 3 months of age the hypertrophied pyloric muscle is partially innervated, and at 7 months of age the pyloric muscle has practically normal innervation. 相似文献
2.
Janwillem Liebrand Margreet Z. Zwarteveen Philippus Wester Barbara van Koppen 《国际水》2013,38(7):773-787
Through investigating the reactions of commercial farmers to land and water reforms in the Trichardtsdal-Ofcolaco area, Limpopo Province, Olifants Basin, South Africa, from 1997 to 2006, it is shown that water claims are key to land redistribution processes, and that commercial farmers make strategic use of arguments for nature conservation and ecological stewardship to defend their claims to water. Given these observations, caution is warranted with respect to the implementation of land and water reforms as separate policy packages; it may be more effective to design water and conservation policies as an integral part of land reform programmes. 相似文献
3.
Abstract Defining and measuring sustainability is a major challenge. This article argues these limitations need not stop us from trying to identify and value the possible impacts of what we are doing, or are thinking about doing, over time periods much longer than the lives of our investments, or even of the lives of those of us living today. Sustainability is a relative concept that must be applied in an environment undergoing multiple changes, changes that are occurring over different temporal and spatial scales. We depend on our water resource systems for our survival and welfare. Yet no one expects them to be restored to, or survive in, their most productive pristine states in the face of increasing development pressures for land in their watersheds and for water in their streams, rivers, lakes, and aquifers. A continuing task of water resource planners and managers is to identify the multiple impacts and tradeoffs resulting from what we who are living today may wish to do for ourselves and our immediate children and what we can only guess our yet-to-be-born descendants may wish us to do, or not do, for them in some distant future. This task must involve professionals from other disciplines in a context much broader than just water management. Once these impacts and tradeoffs are identified, it is then up to the political process to make choices when they are in conflict. All of us need to be a part of this decision-making process. 相似文献
4.
Eugenio Roanes-Lozano Luis M. Laita Eugenio Roanes-Macías Michael J. Wester José Luis Ruiz-Lozano Carlos Roncero 《Mathematics and computers in simulation》2009
The length of the Spanish broad gauge network has decreased in the 1956–2006 period. When looking at different railway maps through this period, it seems that the network is offering fewer and fewer alternatives when a line is cut, that is, the network is becoming less and less flexible. The goal of this article is to prove that the flexibility of the Spanish broad gauge network has decreased substantially in the 1956–2006 period. We have considered the network as a graph (ignoring traditional railway quality indicators such as commercial speed, number of tracks, electrifications, signaling, …) and we have chosen two simple indicators as accurate in this sense: the number of cycles (cycles provide an alternative to reach a station if there is a problem in one line) and the number of stations of intermediate degree. To achieve this, we have developed a piece of software that is an ad hoc extension of Maple’s networks package. 相似文献
5.
Vogel David L.; Wester Steven R.; Larson Lisa M.; Wade Nathaniel G. 《Canadian Metallurgical Quarterly》2006,37(4):398
Despite the presence of quality mental health care in many communities, people tend to avoid seeking help and wind up languishing in their problems unnecessarily. For the professional to better understand how to reach these individuals, an information-processing model is presented that examines the effects of people's interpretation of their environment and their symptoms on their decision to seek mental health services. Using the model as a guide, suggestions are presented for practitioners who wish to provide services to those who are in need of professional help, yet are hesitant to obtain it. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Expression of proliferating cell nuclear antigen (PCNA) as well as p53, bcl-2 and C-erb B-2 genes protein products on Reed-Sternberg/Hodgkin's (R-S/H) cells was analyzed by immunohistochemistry in 65 patients with Hodgkin's disease (HD). Their significance as markers of clinical malignancy and prognostic factors was evaluated. Positive reaction for PCNA was present in 57 cases (87.7%), for p53 in 42 (64.6%), for bcl-2 in 41 (63.1%), and for C-erb B-2 in 38 cases (58.5%) of HD. The high proliferate PCNA index and high expression of p53 and bcl-2 correlated with poor response to the treatment. Expression of both p53 and bcl-2 oncoproteins negatively influenced overall survival and disease free survival. Indexes of PCNA, p53 and bcl-2 were significantly higher in patients with advanced disease then in early clinical stages. In LP type of HD the lowest indexes of PCNA or bcl-2, and even lack of bcl-2 expression on R-S/H cells were observed. There was no correlation between expression of C-erb B-2 and response to the treatment, time of survival, clinical stage or histopathological types of HD. Statistical analysis let us to the conclusion, that indexes of PCNA, p53 and bcl-2 expression can be taken into consideration as a new prognostic factors in Hodgkin's disease. C-erb B-2 protein expression seems to be of no value for prognosis in HD. 相似文献
7.
Our objective was to examine the influence of feeding and endogenous GH secretion on circulating IGF-I in colostrum-deprived newborn pigs fed colostrum (n = 4), formula (control, n = 4), or water (n = 4). In another four formula-fed pigs, GH was ablated (GRF-A) with two intravenous injections of a GH releasing-factor antagonist (N-Ac-Tyr1,D-Arg2)-GRF(1-29)-NH2. Blood was serially sampled in all pigs to measure plasma IGF-I and GH profiles. Feeding increased plasma IGF-I concentration two- to fourfold and decreased GH secretion. Despite a more than 80% decrease in the plasma GH in GRF-A pigs, the circulating IGF-I concentration was similar to that in control pigs. In colostrum-fed pigs, plasma IGF-I was higher than that in control pigs, despite equal nutrient intake and lower circulating GH. There were no differences in plasma IGF binding protein (IGFBP)-3 levels among the treatment groups. However, the relative abundance of plasma IGFBP-4 was lower, and that of IGFBP-1 higher, in unfed pigs than in any of the three fed groups. The plasma insulin concentration was not different among fed pigs, but it was lower in unfed pigs. Our results indicate that the circulating IGF-I concentration is more dependent on nutrient intake than on GH in newborn pigs, despite relatively high GH concentrations. However, because the nutrient content in the formula was designed to match that of colostrum, a factor other than nutrient intake and GH was responsible for the maximal increase in circulating IGF-I concentration observed in colostrum-fed pigs. 相似文献
8.
9.
John Dines Hui Liang Lakshmi Saheer Matthew Gibson William Byrne Keiichiro Oura Keiichi Tokuda Junichi Yamagishi Simon King Mirjam Wester Teemu Hirsimäki Reima Karhila Mikko Kurimo 《Computer Speech and Language》2013,27(2):420-437
In this paper we present results of unsupervised cross-lingual speaker adaptation applied to text-to-speech synthesis. The application of our research is the personalisation of speech-to-speech translation in which we employ a HMM statistical framework for both speech recognition and synthesis. This framework provides a logical mechanism to adapt synthesised speech output to the voice of the user by way of speech recognition. In this work we present results of several different unsupervised and cross-lingual adaptation approaches as well as an end-to-end speaker adaptive speech-to-speech translation system. Our experiments show that we can successfully apply speaker adaptation in both unsupervised and cross-lingual scenarios and our proposed algorithms seem to generalise well for several language pairs. We also discuss important future directions including the need for better evaluation metrics. 相似文献
10.
Heesacker Martin; Wester Stephen R.; Vogel David L.; Wentzel Jeffrey T.; Mejia-Millan Cristina M.; Goodholm Carl Robert Jr. 《Canadian Metallurgical Quarterly》1999,46(4):483
Previous research documents that mental health professionals' attitudes reflect the general public's stereotype of women as hyperemotional. This article reports the results of 6 studies exploring the existence of a complementary stereotype of men as hypoemotional. As predicted, counselors and college students consistently stereotyped men as hypoemotional (all ps?p? 相似文献