Hernia survey of the Section on Surgery of the American Academy of Pediatrics

The members of the Section on Surgery of the American Academy of Pediatrics were surveyed to determine the practice of North American pediatric surgeons in infants with inguinal hernia (IH). Case-scenario multiple-choice-design questionnaires regarding hernias and hydroceles were sent to all members of the Surgical Section, and responses were received from 292 (50%). In healthy full-term infant boys with asymptomatic reducible IH, 82% of responders perform repair electively, no matter what the age or weight. In full-term girls with a reducible ovary, 59% perform surgery at the next available time; if the ovary is nonreducible but asymptomatic, 44% operate emergently or urgently and 42% at the next elective slot. In former preemies, the pattern of repair is as follows. (1) For those recently discharged after 2 months in the neonatal intensive care unit (NICU) with reducible IH, 65% perform the repair when convenient. (2) A general anesthetic is used in 70%; 15% use spinal anesthesia, and 11% use caudal block with sedation. (3) If the repair is done in the hospital outpatient (same-day) unit, 36% wait until 50 weeks postconception (PC) and 33% wait until 60 weeks PC. (4) if the baby's weight is at least 1,000 g. 71% perform the repair before discharge. The pain control choice after childhood IH repair is Tylenol for 30%, local infiltration biquivacaine for 30%, caudal block for 22%, regional block for 11%, and Tylenol/codeine combined for 7%. In 6-week-old full-term infants with communicating hydroceles without definite "hernia," two thirds treat as an IH with elective repair as soon as possible. With respect to contralateral exploration in infants with unilateral IH, 65% perform it in males if they are < or = 2 years of age and 84% use it in females of up to 4 years of age. This approach is not influenced by presenting side, presence of hydrocele, or history of prematurity. Laparoscopic evaluation of the contralateral IH is performed by only 6% of responders, 40% of whom use the open ipsilateral sac for laparoscope introduction.     

Graph structure in the Web

The study of the Web as a graph is not only fascinating in its own right, but also yields valuable insight into Web algorithms for crawling, searching and community discovery, and the sociological phenomena which characterize its evolution. We report on experiments on local and global properties of the Web graph using two AltaVista crawls each with over 200 million pages and 1.5 billion links. Our study indicates that the macroscopic structure of the Web is considerably more intricate than suggested by earlier experiments on a smaller scale.     

A standardized interviewing technique for evaluating postgraduate training applicants

In an effort to streamline the personal interview and to reduce the influence of subjectivity inpreparation of ranking lists for postgraduate year-one applicants, a standardized interview was constructed for use in evaluating condidates for admission to a training program in internal medicine. The interview was conducted in a uniformly structured manner by 14 interviewers of 260 applicants. Each applicant received an interview score which correlated well with the final decision of the Intern Selection Committee. For each interviewer various measures of performance were obtained which allowed a classification into "hard" versus "easy" interviewer and indicated the comparability of each interview's evaluations with the final decisions. Thus, the standardized interview resulted in quantifiable data in the form of uniform evaluations of applicants and interviewers.     

VITAMIN B1 AND RIBOFLAVIN IN BREWING

Vitamin B₁ has been determined in a large number of beers by the fermentation method of Schultz, Atkin and Frey which has not previously been applied to worts and beers. In general, the highest amounts were found in beers of high original gravity and in those made almost entirely from malt. Well-attenuated and unprimed beers give the highest ratio, units of B1: calories. During the brew the malt, almost the sole source of vitamin B₁, yields up the vitamin to the wort, which in its turn loses most of it to the yeast. Most of the vitamin B₁ results have been confirmed by the thiochrome method involving an entirely different principle, whilst the general validity of both methods was further confirmed by animal feedings tests. Determination of Riboflavin (vitamin B₂) by the microbiological method of Snell and Strong has led to the following conclusions:—Riboflavin is formed during germination of barley and in growing yeast. Most of the riboflavin of the malt passes into the wort during mashing and sparging and remains in the beer, the yeast not taking out any appreciable quantity. The number of microgrms. of riboflavin per 100 ml. of beer, in general, exceeds somewhat the number of degrees of original gravity.     

Differential mass spectrometry: a label-free LC-MS method for finding significant differences in complex peptide and protein mixtures

Efficiently identifying and quantifying disease- or treatment-related changes in the abundance of proteins is an important area of research for the pharmaceutical industry. Here we describe an automated, label-free method for finding differences in complex mixtures using complete LC-MS data sets, rather than subsets of extracted peaks or features. The method selectively finds statistically significant differences in the intensity of both high-abundance and low-abundance ions, accounting for the variability of measured intensities and the fact that true differences will persist in time. The method was used to compare two complex peptide mixtures with known peptide differences. This controlled experiment allowed us to assess the validity of each difference found and so to analyze the method's sensitivity and specificity. The method detects both presence versus absence and a 2-fold change in peptide concentration near the limit of detection of the instrument used, where chromatographic peaks may not be sufficiently well defined to be detected in individual samples. The method is more sensitive and gives fewer false positives than subtractive methods that ignore signal variability. Differential mass spectrometry combined with targeted MS/MS analysis of only identified differences may save both computation time and human effort compared to shotgun proteomics approaches.     

Rounds in Combinatorial Search

A set system $\mathcal{H} \subseteq2^{[m]}$ is said to be separating if for every pair of distinct elements x,y∈[m] there exists a set $H\in\mathcal{H}$ such that H contains exactly one of them. The search complexity of a separating system $\mathcal{H} \subseteq 2^{[m]}$ is the minimum number of questions of type “x∈H?” (where $H \in\mathcal{H}$ ) needed in the worst case to determine a hidden element x∈[m]. If we receive the answer before asking a new question then we speak of the adaptive complexity, denoted by $\mathrm{c} (\mathcal{H})$ ; if the questions are all fixed beforehand then we speak of the non-adaptive complexity, denoted by $\mathrm{c}_{na} (\mathcal{H})$ . If we are allowed to ask the questions in at most k rounds then we speak of the k-round complexity of $\mathcal{H}$ , denoted by $\mathrm{c}_{k} (\mathcal{H})$ . It is clear that $|\mathcal{H}| \geq\mathrm{c}_{na} (\mathcal{H}) = \mathrm{c}_{1} (\mathcal{H}) \geq\mathrm{c}_{2} (\mathcal{H}) \geq\cdots\geq\mathrm{c}_{m} (\mathcal{H}) = \mathrm{c} (\mathcal{H})$ . A group of problems raised by G.O.H. Katona is to characterize those separating systems for which some of these inequalities are tight. In this paper we are discussing set systems $\mathcal{H}$ with the property $|\mathcal{H}| = \mathrm{c}_{k} (\mathcal{H}) $ for any k≥3. We give a necessary condition for this property by proving a theorem about traces of hypergraphs which also has its own interest.     

Discussion and Evaluation of the Volatility Test for Equivalency of Other Methods to the Federal Reference Method for Fine Particulate Matter

In July, 1997, the EPA promulgated a new National Ambient Air Quality Standard (NAAQS) for fine particulate matter (PM 2.5 ). This new standard was based on the collection of an integrated mass sample on a filter. Field studies have demonstrated that the collection of semivolatile compounds leads to artifacts and imprecision among methods. In view of such sampling artifacts, a test requirement was promulgated in Title 40, Part 53, Subpart F, Section 53.66 of the Code of Federal Regulations (40CFR53.66) to aid in the determination of methodological equivalency. In this paper, this requirement is critically reviewed and tested in terms of its feasibility and precision. The results show that the test is capable of demonstrating acceptable precision for FRM-type samplers and repeatable differences in performance among different methods. In order to maintain high precision within the entire test procedure, the loading time should be extended to 2 h for flow rates of 16.7 lpm and proportionately longer for lower flow rates.     

Differential K theory and racial hierarchies.

Discusses J. P. Rushton's (see record 1986-17266-001) differential K theory (derived from the r/K model of evolutionary selection), which purportedly explains racial differences in sexual practices and anatomy, fertility, IQ, and criminality. The r/K model is frequently misinterpreted and overgeneralized. The predictions that Rushton derives from the r/K model are arbitrary, and these predictions are supported by selective citation and misrepresentation of the research literature and by the use of unreliable sources. Changes in human life-history traits are so rapid that there is no need to posit genetic selection to explain intergroup variation. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)