用于单芯片系统的改进型WXGA LCoS成像器

本文讨论用于单芯片时序混色的菲利浦DD-720硅基液晶(LCoS)片。这种芯片主要用于HDTV背投影机和多媒体系统。与菲利浦以前的单片LCoS设计相比，由于该芯片具有电接口接点较少、封装简单和温度传感器内置等许多特点，使其应用于投影系统时成本降低。     

Memory complaints in epilepsy: correlations with cognitive performance and neuroticism

Experimental results are presented to show that the adhesion force is the single most important limiting factor in high-resolution atomic force microscopy of DNA in air, prepared by the cytochrome-C-assisted spreading method. It is also shown that humidity plays a minor role in the control of probe force. Using a pure carbon film as the substrate to clean the AFM tip prior to imaging, it is demonstrated that 4-6 nm resolution on DNA can be routinely obtained by the atomic force microscope with commercial Si3N4 pyramid cantilevers. We also show that in organic solvents a resolution of up to 3 nm can be obtained under optimal conditions.     

On the colour reactions of potato glycoalkaloids in strong acids in the presence of paraformaldehyde

The colour reaction of potato glycoalkaloids, containing solanidine as steroid, with strong acids and paraformaldehyde was examined to elucidate the kinetics and mutual relationship of the ‘Clarke’ and ‘Marquis’ reactions. It was found that the influence of time of addition of paraformaldehyde was the major factor in deciding the type of colour changes encountered. This factor and the specific absorption kinetics have important consequences for the use of these types of colour reactions as a quantitative assay. According to the structural similarity of the steroidal part of potato glycoalkaloids and cholesterol, colour reactions of both have been compared, indicating that both steroids react in strong acids in the presence of an oxidator, provided that the more lipophilic character of cholesterol is taken into account. Therefore a similar mechanism of a serial oxidation of carbonium ions as in the case of cholesterol, is suggested as the basis for these specific colour reactions of potato glycoalkaloids.     

Phase equilibrium in a polarized saturated3He—4He mixture

We present experimental results on the phase equilibrium of a saturated³He−⁴He mixture, which has been cooled to a temperature of 10–15 mK and polarized in a⁴He circulating dilution refrigerator to a stationary polarization of 15%, 7 times higher than the equilibrium polarization in the external field of 7 T. The pressure dependence of the polarization enhancement in the refrigerator shows that the molar susceptibilities of the concentrated and dilute phase of a saturared³He-⁴He mixture are equal atp=2.60±0.04 bar. This result affects the Fermi liquid parameters of the dilute phase. The osmotic pressure in the dilute phase has been measured as a function of the polarization of the coexisting concentrated phase up to 15%. We find that the osmotic pressure at low polarization (<7%) agrees well with thermodynamics using the new Fermi liquid parameters of the dilute phase.     

Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro

The calcium-dependent cell-cell adhesion molecule E-cadherin has been shown to counteract invasion of epithelial neoplastic cells. Using three monoclonal antibodies, we have demonstrated the presence of E-cadherin at the surface of human MCF-7/6 mammary carcinoma cells by indirect immunofluorescence coupled to flow cytometry and by immunocytochemistry. Nevertheless, MCF-7/6 cells failed to aggregate in a medium containing 1.25 mM CaCl2, and they were invasive after confrontation with embryonic chick heart fragments in organ culture. Treatment of MCF-7/6 cells with 0.5 microgram ml-1 insulin-like growth factor I (IGF-I) led to homotypic aggregation within 5 to 10 min and inhibited invasion in vitro during at least 8 days. The effect of IGF-I on cellular aggregation was insensitive to cycloheximide. However, monoclonal antibodies that interfered with the function of either the IGF-I receptor (alpha IR3) or E-cadherin (HECD-1, MB2) blocked the effect of IGF-I on aggregation. The effects of IGF-I on aggregation and on invasion could be mimicked by 1 microgram ml-1 insulin, but not by 0.5 microgram ml-1 IGF-II. The insulin effects were presumably not mediated by the IGF-I receptor, since they could not be blocked by an antibody against this receptor (alpha IR3). Our results indicate that IGF-I activates the invasion suppressor role of E-cadherin in MCF-7/6 cells.     

斯芬克司住宅，赫依曾，荷兰

5座斯芬克司住宅的每一栋各容纳了14间为了充分利用地段和阳光而组织起来的公寓。建筑的体量在背向水面的方向被斜切，从而使得从湖岸和公寓所能看到的湖景不被阻隔。当人在从楼里往上走时，公寓的数目逐层递减。结果产生了一种斯芬克司式的轮廓，面向太阳的屋顶退台置于这个神话中的怪兽的脊背上。每个建筑体量的雨篷设计是不同的，从而使其独特的头部产生一种韵律感——从连接新开拓地和现有大陆的stichtse桥上看去的一条激动人心的天际线。     

Impairment of long-term associative memory in aging snails (Lymnaea stagnalis).

Age-dependent impairment in learning and memory functions occurs in many animal species, including humans. Although cell death contributes to age-related cognitive impairment in pathological forms of aging, learning and memory deficiencies develop with age even without substantial cell death. The molecular and cellular basis of this biological aging process is not well understood but seems to involve a decline in the aging brain's capacity for experience-dependent plasticity. To aid in resolving this issue, we used a simple snail appetitive classical conditioning paradigm in which the underlying molecular, cellular, and neural network functions can be directly linked to age-associated learning and memory performance (i.e., the Lymnaea stagnalis feeding system). Our results indicate that age does not affect the acquisition of appetitive memory but that retention and/or consolidation of long-term memory become progressively impaired with advancing age. The latter phenomenon correlates with declining electrophysiological excitability in key neurons controlling the feeding behavior. Together, these results present the Lymnaea feeding system as a powerful paradigm for investigations of cellular and molecular foundations of biological aging in the brain. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Word frequency effects in speech production: Retrieval of syntactic information and of phonological form.

In 7 experiments the authors investigated the locus of word frequency effects in speech production. Exp 1 demonstrated a frequency effect in picture naming that was robust over repetitions. Exps 2, 3, and 7 excluded contributions from object identification and initiation of articulation. Exps 4 and 5 investigated whether the effect arises in accessing the syntactic word (lemma) by using a grammatical gender decision task. Although a frequency effect was found, it dissipated under repeated access to a word's gender. Exp 6 tested whether the robust frequency effect arises in accessing the phonological form (lexeme) by having Ss translate words that produced homophones. Low-frequent homophones behaved like high-frequent controls, inheriting the accessing speed of their high-frequent homophone twins. Because homophones share the lexeme, not the lemma, this suggests a lexeme-level origin of the robust effect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)