The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and Beyond

Recent research on mast cell biology has turned its focus on MRGPRX2, a new member of the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in nociceptive neurons of the dorsal root ganglia. MRGPRX2, a member of this group, is present not only in neurons but also in mast cells (MCs), specifically, and potentially in other cells of the immune system, such as basophils and eosinophils. As emerging new functions for this receptor are studied, a variety of both natural and pharmacologic ligands are being uncovered, linked to the ability to induce receptor-mediated MC activation and degranulation. The diversity of these ligands, characterized in their human, mice, or rat homologues, seems to match that of the receptor’s interactions. Natural ligands include host defense peptides, basic molecules, and key neuropeptides such as substance P and vasointestinal peptide (known for their role in the transmission of pain and itch) as well as eosinophil granule-derived proteins. Exogenous ligands include MC secretagogues such as compound 48/80 and mastoparan, a component of bee wasp venom, and several peptidergic drugs, among which are members of the quinolone family, neuromuscular blocking agents, morphine, and vancomycin. These discoveries shed light on its capacity as a multifaceted participant in naturally occurring responses within immunity and neural stimulus perception, as in responses at the center of immune pathology. In host defense, the mice Mrgprb2 has been proven to aid mast cells in the detection of peptidic molecules from bacteria and in the release of peptides with antimicrobial activities and other immune mediators. There are several potential actions described for it in tissue homeostasis and repair. In the realm of pathologic response, there is evidence to suggest that this receptor is also involved in chronic inflammation. Furthermore, MRGPRX2 has been linked to the pathophysiology of non-IgE-mediated immediate hypersensitivity drug reactions. Different studies have shown its possible role in other allergic diseases as well, such as asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. In this review, we sought to cover its function in physiologic processes and responses, as well as in allergic and nonallergic immune disease.     

Se doped nickel-molybdenum bimetal sulfide with enhanced electrochemical activity for hydrogen evolution reaction

In this work, we synthesized Se doped MoS₂@Ni₃S₂ with nanosheets coated nanorods structure supported on Ni foam (MoNiSeS). Firstly, MoS₂@Ni₃S₂ (MoNiS) nanorods was synthesized by hydrothermal method. After selenization treatment, MoSe₂ successfully formed on the edge of MoS₂ nanosheets and particle Ni₃S₂ transformed into NiSe, in which MoSe₂ and NiSe acted as new phase in MoNiSeS. The obtained MoNiSeS only needs a low overpotential of 68 mV to reach the current density of 10 mA cm^?2, and has a low Tafel plots of 72.77 mV dec^?1 and good electrochemical durability, whose electrochemical activity is much better than that of MoNiS and NiSeS, implying the introduction of Mo and Se is beneficial to improve the electrocatalytic performance of NiS for HER. In addition, the proper amount of Mo source, which has an effect on the morphology of product, has also been investigated. For MoNiSeS, the typical nanosheets coated nanarods expose more active sites and the synergic effects is good to the improvement of the catalytic activity. Meanwhile, WNiSeS has also been prepared using the same method and the corresponding results show that the electrochemical activity of WNiSeS is much better than that of NiSeS, proving the universality of this strategy.     

规整填料和新型塔板设计参数选取的质疑及分析

笔者指出了目前规整填料和新型塔板设计计算中若干尚未完全解决的、有争议或值得进一步完善的设计参数。如:规整填料的每米理论板数、最小液体喷淋密度、最小气体空塔动能因子、新型塔板开孔率等,并提出了具体的设计方案供与同行切磋。     

空中交通预警与防撞系统(TCAS)风险及对策研究

空中交通预警与防撞系统TCAS对飞行安全非常重要,它能够通过对附近的飞机进行冲突检测,预测未来可能发生的危险,提示飞行员避免危险,帮助机组维持与其他飞机之间的空中交通安全间隔;但TCAS本身依然存在风险;在此对TCAS进行了半物理仿真测试,包括数字样机开发测试、物理样机开发测试、虚拟试飞以及数据统计分析等,对其各项功能进行测试与验证;在参阅众多相关文献的基础上,结合所做的研究工作,讨论了TCAS的主要风险,并针对这些风险,提出TCAS在设计、测试、操作方面需要改进的地方,从各方面完善TCAS,降低其风险,进一步保障飞行安全。     

基于模糊数学的高维稀疏数据聚类统计方法设计

传统的数据聚类统计方法仅适用于低维数据聚类问题,为此,本研究设计了基于模糊数据的高维稀疏数据聚类统计方法,以期提升高维稀疏数据的聚类统计效果。以模糊C均值聚类算法为基础,通过优化初始聚类中心解决局部最优问题,缩短聚类统计时间;然后引入权重机制,令该方法适用于高维稀疏数据聚类统计。基于此,以余弦距离替换原有的欧几里德距离,提高高维稀疏数据聚类统计效果。实验证明：在数据维度不同时,该方法均有较优的聚类统计效果。当数据维度较低时,分块比例为10%时聚类统计效果最优;当数据维度较高时,分块比例为40%时聚类统计效果最优。在不同稀疏度等级时,该方法的命中率和聚类统计效率均较高。     

连续浊点法快速测定含盐水溶液的固液平衡

建立一套连续浊点法快速测定含盐水溶液固液平衡的实验方法和装置，不同温度下二元和三元体系的实验值与文献值比较，表明该方法所测数据是可靠的。在此基础上测定了２９８．１５～３２３．１５Ｋ下三元体系ＮＨ４ＣｌＫＣｌＨ２Ｏ的固液平衡数据，并同作者开发的电解质溶液相平衡软件包ＰＨＥＥＳ的预测值作了比较，得到了较为满意的结果     

非水电解质浓溶液的热力学研究(Ⅰ)——用缔合模型关联、推算298.15K时HCL甲醇浓溶液的活度系数

利用HCl在甲醇中稀溶液的活度系数,通过Pitzer的缔合模型,关联出298.15K HCl在甲醇中的缔合常数Kx=1.7×10~2,然后利用HCl在甲醇中浓溶液的活度系数关联出近程作用单参数,进而推算溶剂甲醇的活度系数及溶液总压,均得到满意的结果,说明HCl甲醇浓溶液的热力学关联必须考虑HCl的部分离解效应。     

超长、超大基坑开挖对邻近地铁结构安全影响的数值模拟分析

为了研究超长、超大基坑开挖对邻近地铁结构安全影响,以西安地铁2号线周边某基坑为工程实例,通过运用数值分析软件,结合场地的水文地质和工程地质条件,建立数值模型,进行施工过程的动态模拟,同时进行现场监测,经对比数值模拟结果及监测数据,表明运用PLAXIS软件能有效的模拟基坑开挖过程中的土体变形。同时工程采用的分段、分块开挖,中心岛顺做,周边预留土台反压、使用旋喷锚索的支护方案,对复杂条件下基坑开挖对邻近地铁结构的变形影响能起到有效的控制作用,可对类似工程的设计优化提供有益的参考及借鉴。     

基于Web的数字迎新系统设计与实现

随着高校招生规模越来越大,给迎新工作带来一定的困难,数字迎新系统以校园局域网为基础,实现新生报到前校方新生间信息的相互了解、新生报到业务的办理、数据采集及事后的统计分析功能。本文所设计的数字迎新系统将对高校迎新工作的效率提高、新生报到信息的统计及其它信息系统基础数据提供全面的支持。系统采用JSP相关技术实现。     

基于虚拟现实的数字化校园漫游系统设计

作为数字城市建设的一部分,数字化校园虚拟漫游系统是数字化校园建设计划的核心平台.以桂林电子科技大学金鸡岭校区为原型,运用三维仿真技术建立了基于3DS MAX的虚拟校园三维模型.采用VR-Platform开发平台与SQL server后台数据库连接、虚拟建筑与实景拍摄相结合的方法,设计实时三维虚拟校园漫游系统并实现了自主...