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1.
Responsiveness of self-reported and objective measures of disease severity in carpal tunnel syndrome
JN Katz RH Gelberman EA Wright RA Lew MH Liang 《Canadian Metallurgical Quarterly》1994,32(11):1127-1133
Responsiveness, the ability to detect meaningful clinical change, is a critical attribute of instruments used to evaluate outcomes of treatments. The authors hypothesized that self-administered symptom severity and functional status questionnaires are more responsive to clinical improvement after carpal tunnel release than traditional physical examination measures of strength and sensibility. Data were obtained from a randomized clinical trial of endoscopic versus open carpal tunnel release conducted in four university medical centers. Patients were evaluated before surgery and 3 months after surgery. Seventy-four patients indicating that they were more than 80% satisfied with the results of surgery were assumed to have clinically meaningful improvement and were the focus of the analysis. Evaluations included questionnaires assessing symptom severity, functional status, and activities of daily living as well as measurement of grip, pinch, and abductor pollicus brevis strength, and 2-point discrimination and Semmes-Weinstein pressure sensibility. Responsiveness was calculated with the standardized response mean (mean change/standard deviation of change) as well as the effect size (mean change/standard deviation of baseline values). The symptom severity scale was four times as responsive, and the functional status and activities of daily living scales were twice as responsive, as the measures of strength and sensibility. Self-administered symptom severity and functional status scales are much more responsive to clinical improvement than measures of neuromuscular impairment and should severe as primary outcomes in clinical studies of therapy for carpal tunnel syndrome. 相似文献
2.
Ubiquitin-mediated proteolysis controls the abundance of many cell cycle regulatory proteins. Recent work in Saccharomyces cerevisiae suggests that a complex consisting of Cdc53, Skp1, and a third component known as an F-box protein (termed SCF) in combination with Cdc34 specifically targets regulatory proteins for degradation, and that substrate specificity is likely to be mediated by the F-box subunit. A screen for genetic interactions with a cdc34 mutation yielded MET30, which encodes an F-box protein. MET30 is an essential gene required for cell cycle progression and met30 mutations interact genetically with mutations in SCF components. Furthermore, physical interactions between Met30, Cdc53, Cdc34, and Skp1 in vivo provide evidence for an SCFMet30 complex. We demonstrate the involvement of Met30 in the degradation of the Cdk-inhibitory kinase Swe1. Swe1 is stabilized in met30 mutants and GST-Met30 pull-down experiments reveal that Met30 specifically binds Swe1 in vivo. Furthermore, extracts prepared from cdc34 or met30 mutants are defective in polyubiquitination of Swe1. Taken together, these data suggest that SCF-mediated proteolysis may contribute to the regulation of entry into mitosis. Our data, in combination with previously published results, also provide evidence for distinct SCF complexes in vivo and support the idea that their F-box subunits mediate SCF substrate specificity. 相似文献
3.
4.
An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching 总被引:1,自引:1,他引:0
Tian Fook Kong Huan Shin E Hendrik Santoso Sugiarto Hwi Fen Liew Xinghua Wang Wen Siang Lew Nam-Trung Nguyen Yong Chen 《Microfluidics and nanofluidics》2011,10(5):1069-1078
The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated
magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic
device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads
are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between
two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric
study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental
results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases
with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation
result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz. 相似文献
5.
John S. Lew 《Theory of Computing Systems》1978,12(1):253-270
Denoting the nonnegative (resp. signed) integers byN (resp.Z) and the real numbers byR, letK R
m
andf: R
m
R. Thenf is astoring function (resp.packing function) onK wheneverf|(Z
m
K) is an injection into (resp. bijection onto)N. Unit translations gm of some P. Chowla [1961] polynomials are packing functions on the correspondingN
m
, and all compositions of these polynomials yield further packing functions on variousN
r
. We study this accessible family of packing functions, using standard properties ofordered trees to classify all those compositions, up to a simple equivalence, which define polynomial packing functions on eachN
m
. The numberc(m) of equivalence classes is an exponentially growing function for largem, whence the uniqueness conjecture of our prior two-dimensional work has no counterpart for largerm. We obtain the admissible degrees for composition polynomials inm variables; we describe the tre structures for all such polynomials with extremal degrees. Them-variable polynomials of least degree form a rather irregular numbera(m) of equivalence classes. Density considerations give some degree constraints on ageneral polynomial packing function whose domainK is the topological closure of a nonvoid open cone. 相似文献
6.
Youssef Bokhabrine Ralph Seulin Lew F. C. Lew Yan Voon Patrick Gorria Gouenou Girardin Miguel Gomez Daniel Jobard 《Machine Vision and Applications》2012,23(3):417-425
During industrial forging of hot metallic shells, it is necessary to regularly measure the dimensions of the parts, especially
the inner and outer diameters and the thickness of the walls. A forging sequence lasts 2 h or more during which the diameter
of the shell is regularly measured in order to decide when to stop the forging process. For better working conditions, for
the safety of the blacksmiths, and for a faster and more accurate measurement, we have developed a novel system based on two
commercially available time of flight laser scanners for the measurement of the diameters of hot cylindrical metallic shells
during the forging process. The advantages of using laser scanners are that they can be placed very far from the hot shell,
more than 15 m, while at the same time giving an accurate point cloud from which three-dimensional views of the shell can
be reconstructed and diameter measurements done. Moreover, more accurate measurement is achieved in less time with the laser
system than with the conventional method using a large ruler. The system has been successfully used to measure the diameters
of hot cylindrical metallic shells. 相似文献
7.
HereR andN denote respectively the real numbers and the nonnegative integers. Also 0 <n εN, ands(x) =x
1+...+x
n when x = (x
1,...,x
n) εR
n. Adiagonal function of dimensionn is a mapf onN
n (or any larger set) that takesN
n bijectively ontoN and, for all x, y inN
n, hasf(x) <f(y) whenevers(x) <s(y). We show that diagonalpolynomials f of dimensionn all have total degreen and have the same terms of that degree, so that the lower-degree terms characterize any suchf. We call two polynomialsequivalent if relabeling variables makes them identical. Then, up to equivalence, dimension two admits just one diagonal polynomial,
and dimension three admits just two. 相似文献
8.
We have observed that during temperature-dependent four-terminal resistance measurement of monolayer graphene, the resistance exhibits anomalous rising and falling behavior at different temperature regions. At lower temperature region (2–200 K) the resistance decreases gradually, but when the temperature rise further it turn to a sudden increase, and after 280 K it resumes gradual decrease. The rising and falling resistance behavior is characteristic of semiconductor or metal property. Consequently, the resistance transition follows a phase of semiconductor–metal–semiconductor. However, when a perpendicular magnetic field is applied, the resistance shows reverse transition behavior which follows a sequence of metal–semiconductor–metal. The novel transition property is attributed to the competition between the disorder of lattice defects as a short-range scattering in monolayer graphene and the Landau levels interaction. Magneto-transport measurement reveals that the excitonic gap induced by magnetic field in the monolayer graphene show an anomalous thermally activated property. 相似文献
9.
Amorn Chaiyasat Sirinard Jearanai Lew P Christopher Md Nur Alam 《Polymer International》2019,68(1):102-109
A novel process for the production of superabsorbent materials (hydrogels) from bacterial cellulose (BC) was developed. Prior to crosslinking with a water‐soluble polyethylene glycol diacrylate (PEGDA), BC was first carboxymethylated and functionalized with glycidyl methacrylate. The degree of crosslinking influenced the swelling properties of the hydrogels. The use of greater amounts of PEGDA enhanced the formation of a thicker macromolecular network containing fewer capillary spaces in the crosslinked gel. The maximum water retention value of the hydrogels containing 2.5–3.5 mmol of carboxyl groups per gram of gel reached 125 g g?1 in distilled water, and 29 g g?1 in saline (0.9% NaCl solution). The highly porous hydrogel architecture with a pore size of 350–600 µm created a high specific surface area. This enables rapid mass penetration in superabsorbent applications. The superabsorbent hydrogels reached 80% of their maximum water absorption capacity in 30 min. © 2018 Society of Chemical Industry 相似文献
10.
This paper links the industrial policy and national systems of innovation literature to the investigation of learning capabilities of suppliers in the context of the automotive parts industry of Pakistan. Drawing data from 50 Pakistani autoparts suppliers, the findings suggest that industrial policy has been helpful in creating a local parts supply base and facilitating the entry of Japanese assemblers in the market. However, the implementation of the policy has been weak, and it is an arduous journey for the local suppliers to develop ambidextrous (exploratory and exploitative) learning capabilities. The findings also indicate that where local training and support from R&D institutions are weak, networking alone with foreign multinationals is not sufficient on its own to develop exploratory learning capabilities of local suppliers. This paper shows the importance of creating national–provincial institutions offering learning and skills development aimed towards innovation. 相似文献