Bile acid metabolism in mammals: VI. Effect of ethionine upon bile acids of rat bile

Sex differences in the effect of ethionine upon rat liver metabolism prompted our investigation into possible sex differences in the effect of ethionine upon bile acid metabolism. The bile ducts of 24 rats, 12 male and 12 female, were cannulated. After 1 hr of bile collection, 6 rats of each sex were given ethionine, 1 mg/g body wt, by feeding tube. The bile acid composition of the bile collected during the subsequent 4 hr was analyzed by combined thin layer and gas chromatography. Ethionine induced a reduction in bile flow (3rd and 4th hr) and in bile acid concentration (4th hr) in female rats. The amino acid had no effect upon bile flow but did increase biliary secretion of bile acids (1st and 2nd hr) in male rats. Cholic acid accounted for the bulk of the reduction in total bile acid secretion in the female studies. The increase in total bile acid secretion in the male studies involved all bile acids. The effects of ethionine upon bile acid secretion were delayed in the female studies, immediate in the male. The changes in bile acid secretion involved only the taurine conjugates in the female studies, both taurine and glycine conjugates in the male. There are substantial sex differences in the effect of ethionine upon bile acid metabolism in the rat.     

The effect of epoxy‐polyester hybrid resin on mechanical properties,rheological behavior,and water absorption of polypropylene wood flour composites

The effect of epoxy resin on mechanical and Rheological properties, and moisture absorption of wood flour polypropylene composites (WPCs) were investigated. The reactive mixing of epoxy resin with 30, and 40 wt% wood flour and polypropylene (PP) was carried out in twin screw extruder with a special screw elements arrangement. PP grafted maleic anhydrides (MPP) were used as coupling agent to improve the interfacial interactions of wood flour, epoxy resin, and PP. The tensile strength of composites decreased, and elastic modulus and moisture absorption increased with increasing epoxy resin content. The complex viscosity η* increased with increasing epoxy resin content of composites, and a synergistic effect in increasing the η* was observed at 3 wt% resin. The epoxy resin modified wood‐PP composites that chemically coupled by MPP showed minimum water absorption with highest elastic modulus. The experimental oscillation rheologyical data were used to drive a model to predict the flow behavior of WPCs, in a wide range of frequencies. POLYM. ENG. SCI., 47:2041–2048, 2007. © 2007 Society of Plastics Engineers     

Heavy-fuel flame radiation in gas turbine combustors—exploratory results

With lower costs and greater availability, heavy fuel oil appears as an attractive alternative to the conventional gas oil used in industrial gas turbines. However, higher levels of radiation and smoke are expected, and this note reports on some preliminary tests made with a combustion chamber burning fuels of different carbon content, ranging from kerosine to a 25% blend of residual fuel oil in gas oil, at a chamber pressure of 10 atm^*. The combustion rig was equipped with a total-radiation pyrometer and black-body furnace capable of measurement at different axial stations along the spray-stabilized flame. The presence of the residual fuel oil in the gas oil was found to promote significant increases in the mean levels of radiation, emissivity and smoke density, with a modest increase in liner temperature.     

Applying gravitational search algorithm in the QoS-based Web service selection problem

With the growing use of service-oriented architecture for designing next generation software systems,the service composition problem and its execution complexity have become even more important in resp...     

Bioprinting a cell-laden matrix for bone regeneration: A focused review

Although many efforts have been made to regenerate the bone lesions, existing challenges can be mitigated through the development of tissue engineering scaffolds. However, the weak control on the microstructure of constructs, limitation in preparation of patient-specific and multilayered scaffolds, restriction in the fabrication of cell-laden matrixes, and challenges in preserving the drug/growth factors' efficacy in conventional methods have led to the development of bioprinting technology for regeneration of bone defects. So in this review, conventional 3D printers are classified, then the priority of the different types of bioprinting technologies for the preparation of the cell/growth factor-laden matrixes are focused. Besides, the bio-ink compositions, including polymeric/hybrid hydrogels and cell-based bio-inks are classified according to fundamental and recent studies. Herein, different effective parameters, such as viscosity, rheological properties, cross-linking methods, biodegradation biocompatibility, are considered. Finally, different types of cells and growth factors that can encapsulate in the bio-inks to promote bone repair are discussed, and both in vitro and in vivo achievement are considered. This review provides current and future perspectives of cell-laden bioprinting technologies. The restrictions and challenges are identified, and proper strategies for the development of cell-laden matrixes and high-performance printable bio-inks are proposed.     

AN INTERACTIVE SEARCH ASSISTANT ARCHITECTURE BASED ON INTRINSIC QUERY STREAM CHARACTERISTICS

Search engine query log mining has evolved over time to more like data stream mining due to the endless and continuous sequence of queries known as query stream. In this paper, we propose an online frequent sequence discovery (OFSD) algorithm to extract frequent phrases from within query streams, based on a new frequency rate metric, which is suitable for query stream mining. OFSD is an online, single pass, and real-time frequent sequence miner appropriate for data streams. The frequent phrases extracted by the OFSD algorithm are used to guide novice Web search engine users to complete their search queries more efficiently. YourEye, our online phrase recommender is then introduced. The advantages of YourEye compared with Google Suggest, a service powered by Google for phrase suggestion, is also described. Various characteristics of two specific Web search engine query logs are analyzed and then the query logs are used to evaluate YourEye. The experimental results confirm the significant benefit of monitoring frequent phrases within the queries instead of the whole queries because none-separable items. The number of the monitored elements substantially decreases, which results in smaller memory consumption as well as better performance. Re-ranking the retrieved pages based on past users clicks for each frequent phrase extracted by OFSD is also introduced. The preliminary results show the advantages of the proposed method compared to the similar work reported in Smyth et al.     

Intrusion Detection Systems Using Blockchain Technology: A Review,Issues and Challenges

Intrusion detection systems that have emerged in recent decades can identify a variety of malicious attacks that target networks by employing several detection approaches. However, the current approaches have challenges in detecting intrusions, which may affect the performance of the overall detection system as well as network performance. For the time being, one of the most important creative technological advancements that plays a significant role in the professional world today is blockchain technology. Blockchain technology moves in the direction of persistent revolution and change. It is a chain of blocks that covers information and maintains trust between individuals no matter how far apart they are. Recently, blockchain was integrated into intrusion detection systems to enhance their overall performance. Blockchain has also been adopted in healthcare, supply chain management, and the Internet of Things. Blockchain uses robust cryptography with private and public keys, and it has numerous properties that have leveraged security’s performance over peer-to-peer networks without the need for a third party. To explore and highlight the importance of integrating blockchain with intrusion detection systems, this paper provides a comprehensive background of intrusion detection systems and blockchain technology. Furthermore, a comprehensive review of emerging intrusion detection systems based on blockchain technology is presented. Finally, this paper suggests important future research directions and trending topics in intrusion detection systems based on blockchain technology.     

Study on pharyngeal and uvular consonants in foreign accented Arabic for ASR

This paper investigates the unique pharyngeal and uvular consonants of Arabic from the point of view of automatic speech recognition (ASR). Comparisons of the recognition error rates for these phonemes are analyzed in five experiments that involve different combinations of native and non-native Arabic speakers. The most three confusing consonants for every investigated consonant are discussed. All experiments use the Hidden Markov Model Toolkit (HTK) and the Language Data Consortium (LDC) WestPoint Modern Standard Arabic (MSA) database. Results confirm that these Arabic distinct consonants are a major source of difficulty for Arabic ASR. While the recognition rate for certain of these unique consonants such as // can drop below 35% when uttered by non-native speakers, there is advantage to include non-native speakers in ASR. Besides, regional differences in pronunciation of MSA by native Arabic speakers require the attention of Arabic ASR research.     

Double-diffusive convection with variable viscosity from a vertical truncated cone in porous media in the presence of magnetic field and radiation effects

This work is focused on the study of combined heat and mass transfer or double-diffusive convection near a vertical truncated cone embedded in a fluid-saturated porous medium in the presence of thermal radiation, magnetic field and variable viscosity effects. The viscosity of the fluid is assumed to be an inverse linear function of the fluid temperature. A boundary-layer analysis is employed to derive the non-dimensional governing equations. The governing equations for this investigation are transformed into a set of non-similar equations and solved numerically using the fourth-order Runge–Kutta integration scheme with the Newton–Raphson shooting technique. Comparisons with previously published work on special cases of the problem are performed and the results are found to be in excellent agreement. A parametric study illustrating the influence of the radiation parameter, magnetic field parameter, viscosity-variation parameter, buoyancy ratio and the Lewis number on the fluid velocity, temperature and solute concentration profiles as well as the Nusselt number and Sherwood number is conducted. The results of this parametric study are shown graphically and the physical aspects of the problem are highlighted and discussed.     

UML-CI: A reference model for profiling critical infrastructure systems

The study of critical infrastructure systems organization and behavior has drawn great attention in the recent years. This is in part due to their great influence on the ordinary life of every citizen. In this paper, we study critical infrastructures’ characteristics and propose a reference model based on the Unified Modeling Language (UML). This reference model attempts to provide suitable means for the task of modeling an infrastructure system through offering five major metamodels. We introduce each of these metamodels and explain how it is possible to integrate them into a unique representation to characterize various aspects of an infrastructure system. Based on the metamodels of UML-CI, infrastructure system knowledge bases can be built to aid the process of infrastructure system modeling, profiling, and management.