Fast Positive Feedback Between the Adrenocortical Stress Response and a Brain Mechanism Involved in Aggressive Behavior.

Aggressive behavior induces an adrenocortical stress response, and sudden stressors often precipitate violent behavior. Experiments in rats revealed a fast, mutual, positive feedback between the adrenocortical stress response and a brain mechanism controlling aggression. Stimulation of the aggressive area in the hypothalamus rapidly activated the adrenocortical response, even in the absence of an opponent and fighting. Hypothalamic aggression, in turn, was rapidly facilitated by a corticosterone injection in rats in which the natural adrenocortical stress response was prevented by adrenalectomy. The rapidity of both effects points to a fast, mutual, positive feedback of the controlling mechanisms within the time frame of a single conflict. Such a mutual facilitation may contribute to the precipitation and escalation of violent behavior under stressful conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis

To establish the relationships among T and B cell responses, active infection, and clinical manifestations in lymphatic filariasis, filarial-specific lymphocyte proliferation, IgG antibody isotypes, and IgE levels were determined in an exposed population: 31 asymptomatic amicrofilaremics, 43 microfilaremics, 12 symptomatic amicrofilaremics, and 52 elephantiasis patients. Lymphocyte proliferation was higher in elephantiasis patients and asymptomatic amicrofilaremics than in microfilaremics (P < .004). A proportion of asymptomatic amicrofilaremics (32%), elephantiasis patients (37%), and symptomatic amicrofilaremics (58%) showed antigen-specific lymphocyte unresponsiveness, and lymphocyte proliferation to filarial antigens correlated negatively with specific IgG4 levels (rho = -0.315, P < .001). As elevated specific IgG4 is an indicator of active infection, it is argued that active infection may result in lymphocyte hyporesponsiveness irrespective of clinical category. Of those with elevated specific IgE levels and high T cell proliferative responses, 70% had elephantiasis, suggesting these factors have a role in pathology. However, the existence of a proportion of elephantiasis patients with low anti-filarial IgE and T cell unresponsiveness to filarial antigens suggests that elephantiasis can be caused by distinct processes.     

Modeling the impact of spectral sensor configurations on the FLD retrieval accuracy of sun-induced chlorophyll fluorescence

Chlorophyll fluorescence is related to photosynthesis and can serve as a remote sensing proxy for estimating photosynthetic energy conversion and carbon uptake. Recent advances in sensor technology allow remote measurements of the sun-induced chlorophyll fluorescence signal (Fs) at leaf and canopy scale. The commonly used Fraunhofer Line Depth (FLD) principle exploits spectrally narrow atmospheric oxygen absorption bands and relates Fs to the difference of the absorption feature depth of a fluorescensing and a non-fluorescensing surface. However, due to the nature of these narrow bands, Fs retrieval results depend not only on vegetation species type or environmental conditions, but also on instrument technology and processing algorithms. Thus, an evaluation of all influencing factors and their separate quantification is required to further improve Fs retrieval and to allow a reproducible interpretation of Fs signals.Here we present a modeling study that isolates and quantifies the impacts of sensor characteristics, such as spectral sampling interval (SSI), spectral resolution (SR), signal to noise ratio (SNR), and spectral shift (SS) on the accuracy of Fs measurements in the oxygen A band centered at 760 nm (O₂-A). Modeled high resolution radiance spectra associated with known Fs were spectrally resampled, taking into consideration the various sensor properties. Fs was retrieved using the three most common FLD retrieval methods, namely the original FLD method (sFLD), the modified FLD (3FLD) and the improved FLD (iFLD). The analysis investigates parameter ranges, which are representative for field and airborne instruments currently used in Fs research (e.g., ASD FieldSpec, OceanOptics HR, AirFLEX, AISA, APEX, CASI, and MERIS).Our results show that the most important parameter affecting the retrieval accuracy is SNR, SR accounts for ≤ 40% of the error, the SSI for ≤ 12%, and SS for ≤ 7% of the error. A trade-off study revealed that high SR can partly compensate for low SNR. There is a strong interrelation between all parameters and the impact of specific parameters can compensate or amplify the influence of others. Hence, the combination of all parameters must be considered by the evaluation of sensors and their potential for Fs retrieval. In general, the standard FLD method strongly overestimates Fs, while 3FLD and iFLD provide a more accurate estimation of Fs. We conclude that technical sensor specifications and the retrieval methods cause a significant variability in retrieved Fs signals. Results are intended to be one relevant component of the total uncertainty budget of Fs retrieval and have to be considered in the interpretation of retrieved Fs signals.     

Direct integration of micromachined pipettes in a flow channel forsingle DNA molecule study by optical tweezers

We have developed a micromachined flow cell consisting of a flow channel integrated with micropipettes. The flow cell is used in combination with an optical trap setup (optical tweezers) to study mechanical and structural properties of λ-DNA molecules. The flow cell was realized using silicon micromachining including the so-called buried channel technology to fabricate the micropipettes, the wet etching of glass to create the flow channel, and the powder blasting of glass to make the fluid connections. The volume of the flow cell is 2 μl. The pipettes have a length of 130 μm, a width of 5-10 μm, a round opening of 1 μm and can be processed with different shapes. Using this flow cell we stretched single molecules (λ-DNA) showing typical force-extension curves also found with conventional techniques. These pipettes can be also used for drug delivery, for injection of small gas bubbles into a liquid flow to monitor the streamlines, and for the mixing of liquids to study diffusion effects. The paper describes the design, the fabrication and testing of the flow cell     

Simulation of hyperspectral and directional radiance images using coupled biophysical and atmospheric radiative transfer models

Future remote sensing satellite missions exploring the earth will feature advanced hyperspectral and directional optical imaging instruments. Given the complex nature of the data to be expected from these missions, a thorough preparation for them is essential and this can be accomplished by realistic simulation of the imagery data, years before the actual launch. Based on given spectral and directional capabilities of the instrument, and in combination with biophysical land surface properties obtained from existing imagery, the spectral and directional responses of several types of vegetation and bare soil have been simulated pixel by pixel using the radiative transfer models PROSPECT (for hyperspectral leaf reflectance and transmittance), GeoSAIL (for two-layer canopy bidirectional spectral reflectance), and MODTRAN4 (for atmospheric hyperspectral and directional effects). In this way, one obtains realistically simulated hyperspectral and directional top-of-atmosphere spectral radiance images, with all major effects included, such as heterogeneity of the landscape, non-Lambertian reflectance of the land surface, the atmospheric adjacency effect, and the limited spatial resolution of the instrument. The output of the image simulations can be used to demonstrate the capabilities of future earth observation missions. In addition, instrument specifications and image acquisition strategies might be optimized on the basis of simulated image analysis results, and new advanced data assimilation procedures could be validated with realistic inputs under controlled circumstances. This paper describes the applied methodology, the study area with the input images, the set-up of the actual image simulations, and discusses the final results obtained.     

Optimization of Power Consumption in 4G LTE Networks Using a Novel Barebones Self-adaptive Differential Evolution Algorithm

The power consumption of wireless access networks is an important issue. In this paper, the power consumption of Long Term Evolution (LTE) base stations is optimized. We consider the city of Ghent, Belgium with 75 possible LTE base station locations. We optimize the network towards two objectives: the coverage maximization and the power consumption minimization. We propose a new Barebones Self-adaptive Differential Evolution. The results of the proposed method indicate the advantages and applicability of our approach.     

Changes in land surface temperatures and NDVI values over Europe between 1982 and 1999

We used land surface temperature (LST) algorithms and NDVI values to estimate changes in vegetation in the European continent between 1982 and 1999 from the Pathfinder AVHRR Land (PAL) dataset. These two parameters are monitored through HANTS (Harmonic ANalysis of Time Series) software, which allows the simultaneous observation of mean value, first harmonic amplitude and phase behaviors in the same image. These results for each complete year of data show the effect of volcanic aerosols and orbital drift on PAL data. Comparison of time series of HANTS cloud-free time series with the original time series for various land cover proves that this software is useful for LST analysis, although primarily designed for NDVI applications. Comparison of yearly averages of HANTS LST over the whole Europe with air temperature confirms the validity of the results. Maps of the evolution for both parameters between periods 1982/1986 and 1995/1999 have been elaborated: NDVI data show the well confirmed trend of increase over Europe (up to 0.1 in NDVI), Southern Europe seeing a decrease in NDVI (− 0.02). LST averages stay stable or slightly decrease (up to − 1.5 K) over the whole continent, except for southern areas for which the increase is up to 2.5 K. These results evidence that arid and semi-arid areas of Southern Europe have become more arid, the rest of Europe seeing an increase in its wood land proportion, while seasonal amplitude in Northern Europe has decreased.