~（211）At标记单克隆抗体3H11及其Fab片段对裸鼠人胃癌移植瘤导向治疗的实验研究

用α放射性核素２１１Ａｔ标记的抗胃癌单克隆抗体３Ｈ１１和它的Ｆａｂ片段进行了荷人胃癌裸鼠的实验性治疗研究。经腹腔注射１４．８或２２．２ｋＢｑ／ｇ鼠的标记单抗，每５天一次，连续三次。治疗结果表明，此单抗对肿瘤有较强的抑制作用，治疗１５天后疗效最显著，抑制率分别达６５％和７２％。未发现各重要器官有明显的辐射损伤。     

建材企业战略性资源变化与“十三五”建材产业发展

"十三五"期间是中国经济发展进入新常态的转折之期,也是我国建材工业进行结构调整、转型升级的关键之期。面对国内外错综复杂的发展环境,建材企业作为建材产业发展的微观基础,在"十三五"期间发生的大数据、服务平台建设两大战略性资源变化,必然对建材产业化解产能过剩、实现绿色创新发展、提高两化融合水平等方面产生至关重要的影响。     

C—13NMR谱图智能数据库

介绍了一种应用于Ｃ－１３ ＮＭＲ谱图的智能数据库。利用多种先进的软件工具，在传统数据库的基础上增加了专家系统。有５种检索方式供选择，能方便快速地进行谱图检索。整个系统在ＦｏｘＢＡＳＥ＾＋的支持与管理下运行。介绍了Ｐｒｏｌｏｇ语言与ＦｏｘＢＡＳＥ＾＋的接口知识。     

LABELING McAb 3H11 AND ITS Fab FRAGMENT WITH 211At AND THEIR IMMUNOREACTIVITIES AND INJURY EFFECTS ON HUMAN GASTRIC CANCER CELLS

An antigastric cancer monoclonal antibody,3H11,and its Fab fragment,were labeled using p-(211At)-astatobenzoic acid(pAtBA) intermediate,in the yields of more than 30%.The results of in vitro experiments show that ^211 At-3H11 and ^211At-3H11 Fab are stable,and have specific immunoreactivities and cytotoxic effects to human gastric cancer cell M85,The cytotoxic effects are dependent on the concentration of ^211At-3H11 or 211 At-3H11 Fab and obviously stronger than that of Na^211At.     

TUMOR UPTAKE AND THERAPEUTIC EFFECT OF ASTATINATED INTACT McAb 3H11 AND ITS Fab FRAGMENT FOR HUMAN GASTRIC CANCER XENOGRAFT IN NUDE MICE

The experiments demonstrate that with viewpoint of the pharmacokinetics and therapeutic effect the astatinated Fab fragment is well suited to 7.2h half-life of ^211At,since tumor uptake remains high(-10%/g)from 3 to 14h after i.v.injection of ^211At3H11Fab,moreover,at the same dose the tumor inhibition with 211At-3H11Fab were 84.4% by weight and 86.4% by volume higher than with ^211At-3H11(67.1% and 67.8%,respectively)on 10d pose last i.p.administration.     

~（211）At标记抗胃癌单抗3H11及其Fab片段在荷人胃癌裸小鼠体内的分布

利用ＨＰＬＣ和ＥＬＩＳＡ法对￣（２１１）Ａｔ－３Ｈ１１的分析鉴定表明，间接亲核标记法得到的产品具有３Ｈ１１的天然性和纯度，并保持其免疫活性。￣（２１１）Ａｔ在荷瘤裸小鼠体内分布的结果表明，￣（２１１）Ａｔ－３Ｈ１１Ｆａｂ和￣（２１１）Ａｔ－３Ｈ１１与胃癌细胞有明显的特异亲合力，注射药物３ｈ后，其胃癌摄取率（％／ｇ）分别为９．４８±０．６５和４．９１±２．０５，前者的Ｔ／ＮＴ值在１２－１４ｈ左右明显大于后者。