Nanomaterials for radiotherapeutics-based multimodal synergistic cancer therapy

Over the past decade, numerous studies have attempted to enhance the effectiveness of radiotherapy (external beam radiotherapy and internal radioisotope therapy) for cancer treatment. However, the low radiation absorption coefficient and radiation resistance of tumors remain major critical challenges for radiotherapy in the clinic. With the development of nanomedicine, nanomaterials in combination with radiotherapy offer the possibility to improve the efficiency of radiotherapy in tumors. Nanomaterials act not only as radiosensitizers to enhance radiation energy, but also as nanocarriers to deliver therapeutic units in combating radiation resistance. In this review, we discuss opportunities for a synergistic cancer therapy by combining radiotherapy based on nanomaterials designed for chemotherapy, photodynamic therapy, photothermal therapy, gas therapy, genetic therapy, and immunotherapy. We highlight how nanomaterials can be utilized to amplify antitumor radiation responses and describe cooperative enhancement interactions among these synergistic therapies. Moreover, the potential challenges and future prospects of radio-based nanomedicine to maximize their synergistic efficiency for cancer treatment are identified.

     

A practical reliability assessment approach and its application for pile-stabilized slopes using FORM and support vector machine

Bulletin of Engineering Geology and the Environment - Many uncertainties exist in pile-stabilized slopes which make their design substantially complicated. In this paper, a first-order reliability...     

Ni-Foam Structured Ni-Phyllosilicate Ensemble as an Efficient Monolithic Catalyst for CO2 Methanation

This work proposed a new path to synthesize Ni-phyllosilicate through the reaction of nickel hydroxide and silica sol on the surface of Ni-foam to form the monolithic Ni-phyllosilicate/Ni-foam catalyst. Ni-phyllosilicate could reprint the morphology of nickel hydroxid and firmly anchor on the framework of Ni-foam, which obtained fine Ni particles of 2.8 nm after reduction in H₂ at 650 °C, resulting in high catalytic activity for CO₂ methanation. In addition, the Ni-phyllosilicate/Ni-foam catalyst showed high long-term stability in a 100 h-lifetime test owing to the combined effects of surface confinement of Ni-phyllosilicate, firm anchoring between Ni-phyllosilicate and Ni-foam, as well as the high heat transfer property of Ni-foam.

Graphical Abstract

     

随机库存分配问题的一种求解方法

讨论了在VMI管理思想下对具有随机需求特性的多客户库存分配问题 ,重点论述了有效近似算法的设计过程 ,最后基于一组模拟数据给出了一个算例。     

胡桃夹子

富于节日喜庆气氛的芭蕾舞剧《胡桃夹子》录音、录像繁多。这个伦敦科文特花园歌剧院芭蕾舞团的2000年的现场录像与其它版本比较，     

陆东凹陷油气藏烃类组成非均质性及其意义

陆东凹陷原油和油砂抽提物中烃类的宏观组成存在着明显的非均质性。在高孔隙度(>15%)储层单元中,饱和烃的含量高,占总组成的含量均大于40%,而极性化合物则相对较低,一般不足40%;相反,在低孔隙度(<15%)储层单元中,饱和烃的含量明显降低,而极性化合物则显著增加。此外,陆东凹陷原油和油砂抽提物中烃类成熟度亦存在着非均质性:在高孔隙度储层中,原油和油砂烃类的成熟度参数高,而在低孔隙度储层中原油和油砂烃类的成熟度参数低。根据原油和油砂抽提物中烃类的宏观组成特征和成熟度参数的变化规律,提出了陆东凹陷油气聚集模式。