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排序方式: 共有1608条查询结果,搜索用时 15 毫秒
1.
Coline Grisotto Janice Taïl Cynthia Planesse Nicolas Diotel Marie-Paule Gonthier Olivier Meilhac David Couret 《International journal of molecular sciences》2021,22(9)
Background: Stroke in context of type 2 diabetes (T2D) is associated with a poorer outcome than in non-diabetic conditions. We aimed at creating a new reproducible mouse model of stroke in impaired glucose tolerance conditions induced by high-fat diet. Methods: Adult C57BL6 mice were fed for 2 months with either normal diet (ND) or high-fat diet (HFD). We used a model of Middle Cerebral Artery Occlusion (MCAO) for 90 min. Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) were used to assess pre-diabetic status. Brain infarct volume, hemorrhagic transformation (HT) as well as systemic and cerebral inflammatory markers were evaluated. Results: HFD was associated with an increased body weight and glycemia following OGTT. The HFD group presented a significant increase in brain infarct volume (38.7 (IQR 30–46.7%) vs. 28.45 (IQR 21–30%); p = 0.016) and HT (HFD: 2 (IQR 1–5) vs. ND: 0 (IQR 0–1); p = 0.012) and higher levels of IL-6 and MCP-1 in infarcted hemisphere compared to the ND group. Conclusion: Two months of HFD in adult mice were sufficient to alter the lipid profile and the control of hyperglycemia. These metabolic perturbations were significantly associated with increased infarct volume and hemorrhagic complications. 相似文献
2.
This paper presents an analysis and design procedure for a buoyant cable array antenna used for satellite communications. The towed multi-element array is susceptible to washovers and fluctuations due to the ocean wave interaction with the floating hose where the elements are housed. A model of system performance for coherent multi-element combining is presented based on the dropouts and fades of the individual elements. The array design, including the number and spacing of elements, is shown to be highly dependent on the individual element exposure characteristics and the degree of correlation of the fades between channels. The joint statistics of the array are analyzed using a binary conditional element exposure model and a first-order Markov interelement correlation model. Using this analysis, a family of array designs meeting the communications requirements is produced. 相似文献
3.
Candace Arai Yano Senior Member IIE Robert C. Carlson Senior Member Iie 《IIE Transactions》1985,17(4):370-377
Results of a simulation study of the economics of frequency of rescheduling Material Requirements Planning (MRP) systems are presented for a single-product, two-stage system in which demand is uncertain. The results indicate that for systems with moderate demand uncertainty, frequent rescheduling to maintain customer service may be uneconomical when compared with the alternative of more stable schedules in conjunction with safety stock. This result arises primarily because the cost of “emergency” production setups which occur when rescheduling is frequent exceeds the cost of safety stock required to “protect” stable schedules. 相似文献
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Although past research has described changes in the density of the peripheral benzodiazepine receptor in brain and in peripheral organs in response to stressors and steroid hormone exposure, their combined influence had yet to be determined. This study examined the effect of swim-stress as a function of ovarian hormone administration on the binding of an isoquinoline carboxamide derivative, [3H]PK 11195, in brain and peripheral tissues. In olfactory bulb and adrenal gland, stress increased peripheral benzodiazepine receptor density in ovariectomized rats with and without estradiol and progesterone replacement injection, even when compared with unstressed animals treated with hormones, where estradiol + progesterone decreased peripheral benzodiazepine receptor number in olfactory bulb, but estradiol and estradiol + progesterone increased it in adrenal gland. In frontal cortex, stress decreased peripheral benzodiazepine receptor number, an effect that was reversed by estradiol. In hippocampus estradiol decreased peripheral benzodiazepine receptor density in unstressed animals and estradiol + progesterone decreased peripheral benzodiazepine receptor number in unstressed and stressed animals. In cerebellum, stress, estradiol and estradiol + progesterone alone decreased peripheral benzodiazepine receptor density. In uterus of unstressed controls, estradiol + progesterone increased peripheral benzodiazepine receptor density, and stress produced a further increase in steroid-treated females. Stress did not affect peripheral benzodiazepine receptor density in kidney, except in animals that received estradiol + progesterone injections, where swim-stress produced a significant decrease in peripheral benzodiazepine receptor density. Thus, steroid hormones regulate peripheral benzodiazepine receptor density in endocrine organs and brain, and the hormonal state of the organism modifies the peripheral benzodiazepine receptor response to stress in a tissue- and brain region-specific manner, suggesting that the peripheral benzodiazepine receptor may play a pivotal role in an integrated response to stress. 相似文献
7.
KE McLaughlin IN Jacobs NW Todd GS Gussack G Carlson 《Canadian Metallurgical Quarterly》1997,107(10):1322-1331
Nasopharyngeal stenosis and oropharyngeal stenosis are rare and challenging problems in the pediatric population. The most common etiology is currently the surgical trauma associated with adenotonsillectomy. Stenosis can vary from a thin band to a complete obstructing cicatrix. Presenting symptoms range from mild hyponasal speech to severe airway obstruction. We present a series of eight children with varying degrees of stenosis and associated symptoms. Choice of treatment varied with the severity of disease. In our series, successful interventions included triamcinolone acetonide injection, lysis of adhesions, rotational and advancement mucosal flaps, and jejunal free flap. Preoperative evaluation and individualized surgical repair are essential for successful treatment. 相似文献
8.
Corballis Michael C.; Murray Janice E.; Connolly Gary 《Canadian Metallurgical Quarterly》1989,15(6):1175
Subjects were timed as they decided whether individually presented probe letters were or were not contained in pairs of memorized sets of one, two, or four letters. One set was fixed in advance of a block of trials, while the other varied from trial to trial. In Experiments 1 and 2, subjects responded positively if the probe was in either set and negatively otherwise; in Experiment 3 they made different responses to fixed-set, varied-set, and negative probes. In all three experiments, reaction time (RT) to varied-set probes depended more on the size of the varied set than of the fixed set, whereas RT to fixed-set and negative probes depended more on the size of the fixed set. These results were generally consistent with the hypothesis that scanning of the two sets was at least to some extent concurrent rather than successive, with the fixed set scanned more slowly than the varied set. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
Treatment of exponentially growing cultures ofStreptococcus mutans BHT with growth-inhibitory concentrations (0.2 μg/ml) of benzylpenicillin stimulates the incorporation of [2-14C] acetate into lipids excreted by the cells by as much as 69-fold, but does not change the amount of14C incorporated into intracellular lipids. At this concentration of penicillin cellular lysis does not occur. The radioactive
label is incorporated exclusively into the fatty acid moieties of the glycerolipids. The increase in the radioactive content
of the extracellular lipids reflects an actual net increase in the total fatty acid content as determined by a chemical assay.
During a 4-hr incubation in the presence of penicillin, the extracellular fatty acid ester concentration (per mg cell dry
weight) increases 1.5 fold, even though there is no growth or cellular lysis. No change is observed in the intracellular fatty
acid ester content.
An indication of the relative rate of fatty acid synthesis was most readily obtained by placingS. mutans BHT in a buffer containing14C-acetate. Under these nongrowing conditions free fatty acids are the only lipids labeled, a factor which simplifies the assay.
The addition of glycerol to the buffer causes all of the nonesterified fatty acids to be incorporated into glycerolipid. The
cells excrete much of the lipid whether glycerol is present or not. Addition of penicillin to the nongrowth supporting buffer
system does not stimulate the incorporation of [14C]-acetate into fatty acids. However, if cells are exposed to penicillin in a growth-supporting medium and then are transferred
to the nongrowing buffer system containing no penicillin, the previously exposed cells retain the ability to incorporate [14C]-acetate into fatty acid at a higher rate than untreated cells over a prolonged period of time. The stimulation of [14C]-acetate into fatty acids in this system parallels but is not dependent on the stimulation by penicillin of the incorporation
of [14C]-glycerol into glycerolipid and lipoteichoic acid synthesis previously demonstrated by our laboratory.
The material of this paper is part of a thesis to be submitted by J.L.B. in partial fulfillment of the requirements for the
Ph.D. degree from the Department of Biochemistry, Temple University. 相似文献
10.
The settling rates and adsorption isotherms produced by a variety of suites of cationic polyelectrolytes in 3% kaolin suspensions were measured. Settling rates increased with molar mass even for low-mass, high-charge polymers. The very high settling rates produced by cationic copolymers of acrylamide decreased as the charge density of the polymer used increased. Hydrolysis of unbuffered polymers occurred over time and produced large changes in the effectiveness of the polymers. This is attributed to conformational changes. © 1994 John Wiley & Sons, Inc. 相似文献