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A central event in the life of a cellular system is the interaction between the exterior and the interior compartments. Biochemical signals arrive at the cellular surface, bind to their membrane bound receptor followed by a conformational change triggering the release of an internal chemical or electrical signal.This basic principle is followed by all our perceptive abilities like sense of smell or taste, but also by different signal transduction pathways involved in nerve conductivity, vision, sense of touch or hearing. To follow and mimic this principle of parallel registration is one of the aims of modern nanobiotechnology. If we are able to specifically biofunctionalize small arrays of a solid surface, which could be an electrode or a semiconductor, this approach will enable us to build up devices called “biochips” or “biosensors” that allow the determination of bioactive molecules with high specificity at lowest concentrations. Potential pharmacological active substrates might be screened as well as new receptors may be determined. Applications in genomics as well as proteomics are realistic. The major prerequisite for such a broad spectrum of applications is the fabrication of receptive surfaces. Biomolecules have to be surface‐adsorbed in a highly reproducible, oriented and well organised fashion, a task which in biology is taken by the cellular membranes as external or internal receptive surfaces. The physical principles like hydrogen bonds, electrostatic or hydrophobic interactions that lead to such an organized surface are well known. To synthesize molecular building blocks and to position them onto an otherwise unspecific surface is one of the challenges of nanobiotechnology combining biological knowledge and chemical skills with biophysical techniques that allow to handle or analyze even single molecules. 相似文献
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Joachim Schummer 《Scientometrics》2007,70(3):669-692
Based on bibliometric methods, this paper describes the global institutionalization of nanotechnology research from the mid-1980s
to 2006. Owing to an extremely strong dynamics, the institutionalization of nanotechnology is likely to surpass those of major
disciplines in only a few years. A breakdown of the relative institutionalizations strengths by the main geographical regions,
countries, research sectors, disciplines, and institutional types provides a very diverse picture over the time period because
of different national science policies. The results allow a critical assessment of the different science policies based on
the relative institutionalizations strengths as well as the conclusion that the institutionalization process has run out of
control of individual governments who once induced the development. 相似文献
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Jantsch Simon Müller David Baier Christel Klein Joachim 《Formal Methods in System Design》2021,58(1-2):42-82
Formal Methods in System Design - Due to the high complexity of translating linear temporal logic (LTL) to deterministic automata, several forms of “restricted” nondeterminism have been... 相似文献