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排序方式: 共有236条查询结果,搜索用时 0 毫秒
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S Aeschimann PA Kopp ET Kimura J Zbaeren A Tobler MF Fey H Studer 《Canadian Metallurgical Quarterly》1993,77(3):846-851
Thirty-nine thyroid nodules, removed because of recent growth, were analyzed morphologically by serial histological sections for the classical histomorphological hallmarks of follicular cell replication and for immunohistochemically demonstrable overexpression of the growth-associated ras-gene product p21ras. Clonal analysis was performed using the highly informative probe M27 beta that detects polymorphisms on the locus DXS255 of the X-chromosome. Twenty-four nodules were of clonal and 15 nodules were of poly-clonal origin. Only 3 out of the 24 clonal nodules were histomorphologically uniform. In all others, the structural hallmarks of active growth and the P21ras growth-marker expression were remarkably heterogeneous throughout the tumors. There were no histomorphological characteristics distinguishing these clonal tumors from polyclonal nodules. Even if a clonal thyroid tumor may be originally homogeneous in respect to the parameters studied here, mechanisms must exist that create wide heterogeneity of growth and of morphogenetic potential among the individual follicular cells during further expansion of the nodule. Thus, clonal nodules are much more common in nodular goiters than hitherto assumed on grounds of the classical morphological criteria. The diagnosis of a true monoclonal nodule can no longer rely on morphological and functional criteria alone but requires molecular or cytogenetic analysis of clonality. 相似文献
3.
Leonhard E. Bernold 《Canadian Metallurgical Quarterly》2003,129(6):645-652
The need for better protecting our vital infrastructure from being damaged or destroyed has received increased attention since the terrorist attacks on September 11, 2001. The tragedy of having thousands of innocent people die before the eyes of an entire nation awakened people to the reality of “managed” attacks of unthinkable magnitudes. However, tragedies of a smaller scale are a daily occurrence but accepted as “collateral damage” of work in an unsafe environment. This paper presents a cost-benefit analysis to address the question of how much money should be spent in protecting underground utilities from damage. During the study of an actual incident it was found that the total costs of such accidents are vastly underreported because only costs for emergency responses and repair are tallied up. This paper makes the case that a comprehensive approach for assessing the total economic impact of such incidents on the public, business, and government is the critical stepping stone to a mathematical optimization of expenditure for damage prevention. In addition, the reader will quickly realize that the use of the presented optimization model provides theoretical underpinning for the engineering profession in its effort to better protect our critical infrastructure from terrorist attacks. 相似文献
4.
Richard D. Dick William L. Fourney Deborah J. Goodings Chaun‐Ping Lin Leonhard E. Bernold 《Canadian Metallurgical Quarterly》1992,5(1):59-69
The utilization of explosives for excavation on the lunar surface is under serious consideration as a part of the design for construction of temporary and permanent bases. An excavation research program has shown that small‐scale explosives blasting in a lunar‐soil simulant will greatly reduce the digging forces required for scoop and dragline excavators. Some crater‐blasting parameters were determined for the lunar soil simulant at one Earth gravity and at 10 Earth gravities using a centrifuge. The size of the craters produced at 10 Earth gs matched those formed at one earth g by scaling according to the weight of the explosive. These data can be applied to explosive‐excavation problems such as habitat construction, burial of nuclear power sources, and the rapid construction of shelters remote from the main base to shield against solar‐flare activity. 相似文献
5.
A Review of Metal Fabricated with Laser‐ and Powder‐Bed Based Additive Manufacturing Techniques: Process,Nomenclature, Materials,Achievable Properties,and its Utilization in the Medical Sector 下载免费PDF全文
6.
Beckel W. Ludorff J. Großfeld Baars Bäurle Brüning Griebel Lars Erlandsen Steinbeck W. Hämmerle Reichard W. Schreiber Jesser Kanitz Hans Hawelka Tobler Kluge Patzsch Schönfeld F. Zacher M. Gordienko G. Stamm Lerche Schloemer Schwaibold O. Windhausen Haevecker Diemair W. Brandt G. Steinhoff K. Höll Schönfeld K. Müller G. Moderow und W. Sutthoff 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1941,81(6):508-576
Ohne Zusammenfassung 相似文献
7.
Prof. Dr. Andreas Leson Gregor Englberger Daniel Hammer Stefan Makowski Carl‐Friedrich Meyer Michael Leonhard Hans‐Joachim Scheibe Volker Weihnacht 《真空研究与实践》2015,27(4):24-28
Diamond‐like carbon thin films enhance efficiency — laser arc deposition of ta‐C Rising prices for fossil fuels as well as the increasing effects of the climate change due to the emission of greenhouse gases reveal the necessity of saving energy. Low friction coatings have an enormous potential in saving energy. Carbon based coatings — named as DLC coatings — are especially well suited for low friction coatings. In particular hydrogen‐free tetrahedral amorphous carbon (ta‐C) coatings are of great interest due to their extraordinary low wear properties. In addition they show excellent low friction properties and especially in combination with specific lubricants the so‐called super low friction effect. For the deposition of ta‐C coatings PVD methods have to be applied instead of CVD methods as it is the case for conventional DLC coatings. We have developed a deposition method which is based on a pulsed arc steered by a laser (Laser‐Arc). This allows us to use large cathodes resulting in a high long‐term stability. Furthermore, the carbon plasma source can be combined with a filtering unit removing almost all droplets and particles, which usually are characteristic for an arc process. The resulting Laser‐Arc source allows for the deposition of smooth and virtually defect‐free ta‐C coatings with a competitive deposition rate. 相似文献
8.
Pauline Hibon Heinz von Seggern Hsin-Rong Tseng Christoph Leonhard Manuel Hamburger Gaëlle Béalle 《应用聚合物科学杂志》2020,137(29):48895
Interface control remains a top challenge of solution-processed organic light emitting diodes (OLED) stacks since the device performance heavily relies on it. Film stability of an inkjet deposited and crosslinked layer against subsequent exposure to a suitable inkjet printed solvent has been investigated. Impact of processing solvent (solvent used to prepare the polymer layer) on solution-cast thin film properties has already been shown for polymer films. To our knowledge, this study is the first one analyzing thin films stability against solvent exposure using technology relevant materials processed via inkjet printing (IJP). The outcome of this research showed that the stability of the crosslinked films is affected by the solvent used for ink formulation. These findings are of great interest for multilayered semiconductors devices, such as OLEDs, field-effect transistors and dye-sensitized solar cells. Differential scanning calorimetry (DSC) was used to quantify the efficiency of the polymer crosslinking reaction in pure powder and in thin films, as processed from different solvents. Crosslinking efficiency measured by DSC correlated well with the deformation induced by the solvent and observed on layer surfaces. The interaction in solution between polymer and solvent has also been evaluated to explain its impact on thin film stability against successive solvent printing. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48895. 相似文献
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Stefano Panebianco Klara Berg Jean-Christophe David Mohamed Eid Uwe Filges Friedrich Gröschel Arnaud Guertin Alexander Yu Konobeyev Christian Latgé Sébastien Lemaire Sylvie Leray Alain Letourneau Markus Lüthy Franco Michel-Sendis Selene Scazzi Gediminas Stankunas Nicolas Thiollière Leonhard Tobler Luca Zanini 《Annals of Nuclear Energy》2009
The MEGAPIE project aimed to design, build and operate a liquid metal spallation neutron target of about 1 MW beam power in the SINQ facility at the Paul Scherrer Institut (Villigen, Switzerland). This project is an important step in the roadmap towards the demonstration of the accelerator driven system (ADS) concept and high power liquid metal targets in general. Following the design phase, an experimental program was defined to provide a complete characterization of the facility by performing a “mapping” of the neutron flux at different points, from the center of the target to the beam lines. The neutronic performance of the target was studied using different experimental techniques with the goals of validating the Monte Carlo codes used in the design of the target; additionally, the performance was compared with the solid lead targets used before and after the MEGAPIE experiment. 相似文献