New technological solutions to protect the lining of blast-furnace hearths

The use of schungite as a partial replacement for coke is practiced in Russia at a number of metallurgical plants, both in the production of foundry iron (its primary use) and in making conversion pig iron. The largest amount of coke is replaced when foundry iron is being made, the replacement coefficient in this case having a value within the range 0.8–1.3. Studies that included continuous monitoring of the temperature of the carbon blocks in blast furnaces with volumes of 1719, 3200, and 5580 m³ unambiguously demonstrate that the thickness of the slag crust in blast furnaces increases with the use of schungite. Protecting the lining of the hearth through the use of schungite is also accompanied by a decrease in coke consumption. __________ Translated from Metallurg, No. 8, pp. 53–57, August, 2007.     

Field evaporation of carbidized tungsten

The field evaporation of carbidized tungsten (ribbed crystals) was studied by the atom probe method at various temperatures of the sample in the regions of cryogenic, room, and elevated (1300–1600 K) temperatures. For a high pulsed (not less than 40%) component in the evaporating field, the room-temperature field evaporation mass spectra correctly reflect the surface composition of the evaporated sample. The mass spectra reveal a large number of molecular and polymerized (cluster) ions. Data from field ion desorption microscopy indicate that high-temperature field evaporation of a ribbed crystal proceeds via ion emission from walking and merging thermal-field microroughnesses.     

Dynamics of the magnetic field transport in a plasma opening switch

It is shown that the process of magnetic field penetration into the plasma bridge in a plasma opening switch is determined by the field diffusion near the magnetic piston, followed by the convective transport of magnetic field in the bridge. This transport is due to the field being “frozen in” to the flow of plasma behind the front of a shock wave, which is formed in the plasma accelerated by the magnetic field pressure.     

The role of modelling in identifying drug targets for diseases of the cell cycle.

The cell cycle is implicated in diseases that are the leading cause of mortality and morbidity in the developed world. Until recently, the search for drug targets has focused on relatively small parts of the regulatory network under the assumption that key events can be controlled by targeting single pathways. This is valid provided the impact of couplings to the wider scale context of the network can be ignored. The resulting depth of study has revealed many new insights; however, these have been won at the expense of breadth and a proper understanding of the consequences of links between the different parts of the network. Since it is now becoming clear that these early assumptions may not hold and successful treatments are likely to employ drugs that simultaneously target a number of different sites in the regulatory network, it is timely to redress this imbalance. However, the substantial increase in complexity presents new challenges and necessitates parallel theoretical and experimental approaches. We review the current status of theoretical models for the cell cycle in light of these new challenges. Many of the existing approaches are not sufficiently comprehensive to simultaneously incorporate the required extent of couplings. Where more appropriate levels of complexity are incorporated, the models are difficult to link directly to currently available data. Further progress requires a better integration of experiment and theory. New kinds of data are required that are quantitative, have a higher temporal resolution and that allow simultaneous quantitative comparison of the concentration of larger numbers of different proteins. More comprehensive models are required and must accommodate not only substantial uncertainties in the structure and kinetic parameters of the networks, but also high levels of ignorance. The most recent results relating network complexity to robustness of the dynamics provide clues that suggest progress is possible.     

Mathematical simulation of the viscous properties of concentrated suspensions

A mathematical model for calculating the viscous properties of concentrated suspensions characterized by particle sizes of 30 to 800 µm), solids volume fractions of 1 to 70 vol %, different particle-size distributions, and a shear-rate range of 0.16 to 437 s^?1, which can describe the time evolution of the properties, is proposed. The model can be applied to calculating the viscous properties of catalyst oxide pastes, particulate-filled polymeric pastes, and the like.     

Liver Lipids of Patients with Hepatitis B and C and Associated Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) still remains a difficult to cure malignancy. In recent years, the focus has shifted to lipid metabolism for the treatment of HCC. Very little is known about hepatitis B virus (HBV) and C virus (HCV)-related hepatic lipid disturbances in non-malignant and cancer tissues. The present study showed that triacylglycerol and cholesterol concentrations were similar in tumor adjacent HBV and HCV liver, and were not induced in the HCC tissues. Higher levels of free cholesterol, polyunsaturated phospholipids and diacylglycerol species were noted in non-tumorous HBV compared to HCV liver. Moreover, polyunsaturated phospholipids and diacylglycerols, and ceramides declined in tumors of HBV infected patients. All of these lipids remained unchanged in HCV-related HCC. In HCV tumors, polyunsaturated phosphatidylinositol levels were even induced. There were no associations of these lipid classes in non-tumor tissues with hepatic inflammation and fibrosis scores. Moreover, these lipids did not correlate with tumor grade or T-stage in HCC tissues. Lipid reprogramming of the three analysed HBV/HCV related tumors mostly resembled HBV-HCC. Indeed, lipid composition of non-tumorous HCV tissue, HCV tumors, HBV tumors and HBV/HCV tumors was highly similar. The tumor suppressor protein p53 regulates lipid metabolism. The p53 and p53S392 protein levels were induced in the tumors of HBV, HCV and double infected patients, and this was significant in HBV infection. Negative correlation of tumor p53 protein with free cholesterol indicates a role of p53 in cholesterol metabolism. In summary, the current study suggests that therapeutic strategies to target lipid metabolism in chronic viral hepatitis and associated cancers have to consider disease etiology.     

Whispering gallery modes in photoluminescence and Raman spectra of a spherical microcavity with CdTe quantum dots: anti-Stokes emission and interference effects

We have studied the photoluminescence and Raman spectra of a system consisting of a polystyrene latex microsphere coated by CdTe colloidal quantum dots. The cavity-induced enhancement of the Raman scattering allows the observation of Raman spectra from only a monolayer of CdTe quantum dots. Periodic structure with very narrow peaks in the photoluminescence spectra of a single microsphere was detected both in the Stokes and anti-Stokes spectral regions, arising from the coupling between the emission of quantum dots and spherical cavity modes.     

Coherent structure formation,phase correlations,and finite-size effects in 2D turbulence

General conditions for the formation of long-lived coherent vortices in decaying and force-driven 2-D turbulence are investigated. It is shown by a series of numerical simulations that the emergence of closed streamlines leading to the trapped trajectories of vorticity is a necessary, but not sufficient condition for this phenomenon, so that these trapped trajectories may be considered only as seed vortices. Numerical experiments which demonstrate the relations between phase correlations, finite-size effects, and the formation of coherent vortices in 2-D decaying turbulence are presented. It is shown that there is a universal dimensionless time for the onset of intermittency in the flow which corresponds to the time of establishment of phase correlations. The stricter conditions for appearance of coherent vortices in forced turbulence in comparison with decaying turbulence are associated with phase mixing introduced by random forcing. The universal features of decaying turbulence are discussed in terms of phase portraits based on inviscid constants of motion and their decay rates.