Influence of regular aerobic exercise on psychological health: A randomized, controlled trial of healthy middle-aged adults.

Evaluated 120 healthy, sedentary, middle-aged adults randomly assigned to either a 6-mo home-based aerobic exercise training program or to an assessment-only control condition. Adherence across the 6-mo period by the exercise group was demonstrated by self-report and heart rate microprocessor methods to exceed 75%. A 14-item Likert rating scale was used to measure a variety of psychological variables. Significant between-groups differences favoring the exercise group were found on scale items closely associated with actual physical changes that occurred with exercise (satisfaction with shape/appearance, perceived fitness). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Molecular recognition in the sphingosine 1-phosphate receptor family

Computational modeling and its application in ligand screening and ligand receptor interaction studies play important roles in structure-based drug design. A series of sphingosine 1-phosphate (S1P) receptor ligands with varying potencies and receptor selectivities were docked into homology models of the S1P(1-5) receptors. These studies provided molecular insights into pharmacological trends both across the receptor family as well as at single receptors. This study identifies ligand recognition features that generalize across the S1P receptor family, features unique to the S1P(4) and S1P(5) receptors, and suggests significant structural differences of the S1P(2) receptor. Docking results reveal a previously unknown sulfur-aromatic interaction between the S1P(4) C5.44 sulfur atom and the phenyl ring of benzimidazole as well as pi-pi interaction between F3.33 of S1P(1,4,5) and aromatic ligands. The findings not only confirm the importance of a cation-pi interaction between W4.64 and the ammonium of S1P at S1P(4) but also predict the same interaction at S1P(5). S1P receptor models are validated for pharmacophore development including database mining and new ligand discovery and serve as tools for ligand optimization to improve potency and selectivity.     

Searching for multimedia: analysis of audio,video and image Web queries

The development of digital libraries has enhanced the integration of textual and multimedia information in many document collections. The World Wide Web provides the connectivity for many digital library users. Studies exploring the searching characteristics of Web users are an important and a growing area of research. Most Web user studies have focused on general Web searching, regardless of subject matter or format. Little research has examined how Web users search for multimedia information. Our study examines users' multimedia searching on a major Web search service. The data set examined consisted of 1,025,908 queries from 211,058 users of Excite ®, a major Web search service. From this data set, we identified and analyzed queries for audio, image, and video queries. Our findings were compared to results from general Web searching studies. Implications for the design of Web searching services and interfaces are discussed.     

线条勾勒精彩家居

在家居生活多元化的今天，越来越多的设计师将“玩”的心态加入作品设计中。简单的线条组合成多变的图案，直线、曲线、方形、圆形，为家具、饰品带来了与众不同的形象，更为我们的家居生活带来了非比寻常的精彩体验。     

浪漫烛光

跳跃的火苗，透过阿拉伯通花银环映出室内异域风情，在海浪般的线条上优雅燃烧，温柔释放浪漫分子。     

镂空之美

镂空作为一种雕刻技术，需要精湛且细腻的工艺。设计师巧妙地将这一传统元素融入现代生活中，为我们带来时尚且个性的家居生活。     

惊喜家居设计 跨越无限可能

在这个充满新意的年代，创意已成为家居设计中不可或缺的部分。实用的功能，漂亮的外形？这还不够。聪慧的设计师利用各种元素。跨越区域的界限．设计出别具新意的家居产品，为我们带来耳目一新的惊喜体验。     

Do logistic regression and signal detection identify different subgroups at risk? Implications for the design of tailored interventions.

Identifying subgroups of high-risk individuals can lead to the development of tailored interventions for those subgroups. This study compared two multivariate statistical methods (logistic regression and signal detection) and evaluated their ability to identify subgroups at risk. The methods identified similar risk predictors and had similar predictive accuracy in exploratory and validation samples. However, the 2 methods did not classify individuals into the same subgroups. Within subgroups, logistic regression identified individuals that were homogeneous in outcome but heterogeneous in risk predictors. In contrast, signal detection identified individuals that were homogeneous in both outcome and risk predictors. Because of the ability to identify homogeneous subgroups, signal detection may be more useful than logistic regression for designing distinct tailored interventions for subgroups of high-risk individuals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

精彩户外 畅享浪温日光

碧水蓝天总是为我们的美梦提供着层出不穷的想象。新鲜的空气、开阔的视野、诱人的美食……让愉悦的心情一发不可收拾。现在，就将身心带到美丽的户外，一起享受阳光下的精彩时光。