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Kandukuri Rama Krishna Achterhold Jan Moeller Michael Stueckler Joerg 《International Journal of Computer Vision》2022,130(1):3-16
International Journal of Computer Vision - Representation learning for video is increasingly gaining attention in the field of computer vision. For instance, video prediction models enable activity... 相似文献
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Lin Yang Regine Gradl Martin Dierolf Winfried Mller David Kutschke Annette Feuchtinger Lorenz Hehn Martin Donnelley Benedikt Günther Klaus Achterhold Axel Walch Tobias Stoeger Daniel Razansky Franz Pfeiffer Kaye S. Morgan Otmar Schmid 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(49)
Targeted delivery of nanomedicine/nanoparticles (NM/NPs) to the site of disease (e.g., the tumor or lung injury) is of vital importance for improved therapeutic efficacy. Multimodal imaging platforms provide powerful tools for monitoring delivery and tissue distribution of drugs and NM/NPs. This study introduces a preclinical imaging platform combining X‐ray (two modes) and fluorescence imaging (three modes) techniques for time‐resolved in vivo and spatially resolved ex vivo visualization of mouse lungs during pulmonary NP delivery. Liquid mixtures of iodine (contrast agent for X‐ray) and/or (nano)particles (X‐ray absorbing and/or fluorescent) are delivered to different regions of the lung via intratracheal instillation, nasal aspiration, and ventilator‐assisted aerosol inhalation. It is demonstrated that in vivo propagation‐based phase‐contrast X‐ray imaging elucidates the dynamic process of pulmonary NP delivery, while ex vivo fluorescence imaging (e.g., tissue‐cleared light sheet fluorescence microscopy) reveals the quantitative 3D drug/particle distribution throughout the entire lung with cellular resolution. The novel and complementary information from this imaging platform unveils the dynamics and mechanisms of pulmonary NM/NP delivery and deposition for each of the delivery routes, which provides guidance on optimizing pulmonary delivery techniques and novel‐designed NM for targeting and efficacy. 相似文献
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Cozzoli PD Snoeck E Garcia MA Giannini C Guagliardi A Cervellino A Gozzo F Hernando A Achterhold K Ciobanu N Parak FG Cingolani R Manna L 《Nano letters》2006,6(9):1966-1972
Tetrapod-shaped maghemite nanocrystals are synthesized by manipulating the decomposition of iron pentacarbonyl in a ternary surfactant mixture under mild thermal conditions. Adjustment of the reaction parameters allows for the systematic tuning of both the width and the length of the tetrapod arms, which grow preferentially along the 111 easy axis direction. Such degree of control leads to modulation of the magnetic behavior of the nanocrystals, which evolves systematically as their surface magnetization phase and shape anisotropy are progressively increased. 相似文献
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