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1.
Pierre Santucci Christina Dedaki Alexandros Athanasoulis Laura Gallorini Anaïs Munoz Dr. Stéphane Canaan Dr. Jean-François Cavalier Dr. Victoria Magrioti 《ChemMedChem》2019,14(3):349-358
In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents. 相似文献
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Alexandros Papadopoulos Issaak Parcharidis Panagiotis Elias Pierre Briole 《International journal of remote sensing》2019,40(16):6365-6382
We analysed the ground deformation across two blocks defined by the Rio-Patras fault from 1993 to 2017 using multi-temporal Synthetic Aperture Radar Interferometry (InSAR) techniques. Our main objective was to contribute to the assessment of seismic hazard near the large city of Patras. Multiple data-sets were used, each one covering different temporal periods. Descending and ascending acquisitions, providing different viewing geometries contribute to fully determine the ground displacement in 3D. The data-sets used are from the European Space Agency’s (ESA) European Remote Sensing (ERS), Environmental Satellite (ENVISAT) and SENTINEL-1 as well as German Aerospace Center (DLR) ’s TERRASAR-X missions. Considering ESA’s missions covering both acquisition geometries and long periods, the southern block, showing lack of a sufficient number of scatterers does not allow the displacement characterization. In contrary, the northern block is characterized by a high number of scatterers having values of maximum likehood ranging from ?3.5 to ?4.3 mm year?1 for ascending geometry and from ?1.6 to ?2.7 mm year?1 for the descending one. The fact that both geometries show negative values of displacements are consistent with downlift movement and at the same time the quantitative differentiation probably indicates an horizontal component as well. 相似文献
3.
Suitability,efficiency and microbiological safety of novel physical technologies for the processing of ready‐to‐eat meals,meats and pumpable products
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Alexandros Ch. Stratakos Anastasios Koidis 《International Journal of Food Science & Technology》2015,50(6):1283-1302
Consumer studies and market reports show an increase in consumption of ready‐to‐eat (RTE) foods. Although conventional processing technologies can in most cases produce safe products, they can also lead to the degradation of nutritional compounds and negatively affect quality characteristics. Consumers strongly prefer food that is minimally processed with the maximum amount of health‐promoting substances. Novel processing technologies as pre‐ or post‐treatment decontamination methods or as substitutes of conventional technologies have the potential to produce foods that are safe, rich in nutrient content and with superior organoleptic properties. Combining novel with conventional processes can eliminate potential drawbacks of novel technologies. This review examines available scientific information and critically evaluates the suitability and efficiency of various novel thermal and nonthermal technologies in terms of microbial safety, quality as well as nutrient content on the production of RTE meals, meats and pumpable products. 相似文献
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Papatheodorou Nikolaos Kouroupetroglou Georgios Pino Alexandros Giannopoulos Panagiotis-Alexios Makris Gerasimos Papageorgiou Charalambos 《Universal Access in the Information Society》2021,20(2):321-331
Universal Access in the Information Society - We present an investigation of the systematic differences in upper limb motor skills between children with learning disabilities (LDs) and children... 相似文献
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Soil fabric anisotropy tensors are related to the statistical distribution of orientation of different microstructural vector-like entities, most common being the contact normal vectors between particles, which are extremely difficult to determine for real granular materials. On the other hand, void fabric based tensors can be determined by image based quantification methods of voids (graphical approaches), which are well defined and easy to apply to both physical and numerical experiments. A promising void fabric characterization approach is based on the scan line method. Existing scan line based definitions of void fabric anisotropy tensors are shown analytically to inherit a shortcoming, since numerous small void segments in a sample have an inordinate contribution towards unwarranted isotropy. Discrete Element Method (DEM) of analysis subsequently confirms this analytical proof. The fact that such scan line void fabric tensor definitions yield acceptable results when used in conjunction with physical image-based measurements, is shown to be attributed to the natural “cut off” of smaller void segments that occurs during such measurements. This is the motivation to propose using the existing definition of void fabric tensors, with exclusion of void segments less than a “cut off” value associated with an internal length of the granular assembly. In addition, an entirely new void fabric tensor was introduced using the squared length, instead of the length of a void segment, as the weighting factor for the definition of the scan line void fabric tensor. It was found by means of DEM analysis that both alternative definitions are void of the aforementioned shortcoming and compatible with existing image quantification methods of void fabric anisotropy. 相似文献
9.
Recent advances in the field of kernel-based machine learning methods allow fast processing of text using string kernels utilizing suffix arrays. kernlab provides both kernel methods’ infrastructure and a large collection of already implemented algorithms and includes an implementation of suffix-array-based string kernels. Along with the use of the text mining infrastructure provided by tm these packages provide R with functionality in processing, visualizing and grouping large collections of text data using kernel methods. The emphasis is on the performance of various types of string kernels at these tasks. 相似文献
10.
Flip Korn Alexandros Labrinidis Yannis Kotidis Christos Faloutsos 《The VLDB Journal The International Journal on Very Large Data Bases》2000,8(3-4):254-266
Association Rule Mining algorithms operate on a data matrix (e.g., customers products) to derive association rules [AIS93b, SA96]. We propose a new paradigm, namely, Ratio Rules, which are quantifiable in that we can measure the “goodness” of a set of discovered rules. We also propose the “guessing
error” as a measure of the “goodness”, that is, the root-mean-square error of the reconstructed values of the cells of the
given matrix, when we pretend that they are unknown. Another contribution is a novel method to guess missing/hidden values
from the Ratio Rules that our method derives. For example, if somebody bought $10 of milk and $3 of bread, our rules can “guess”
the amount spent on butter. Thus, unlike association rules, Ratio Rules can perform a variety of important tasks such as forecasting,
answering “what-if” scenarios, detecting outliers, and visualizing the data. Moreover, we show that we can compute Ratio Rules
in a single pass over the data set with small memory requirements (a few small matrices), in contrast to association rule mining methods
which require multiple passes and/or large memory. Experiments on several real data sets (e.g., basketball and baseball statistics,
biological data) demonstrate that the proposed method: (a) leads to rules that make sense; (b) can find large itemsets in
binary matrices, even in the presence of noise; and (c) consistently achieves a “guessing error” of up to 5 times less than
using straightforward column averages.
Received: March 15, 1999 / Accepted: November 1, 1999 相似文献