排序方式: 共有21条查询结果,搜索用时 15 毫秒
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Nuchanart Suealek Thipaporn Tharavanij Robert M. Hackman Carl L. Keen Roberta R. Holt Benjapun Burawat Ammara Chaikan Rattana Tiengtip Panadda Rojpibulstit 《European Journal of Lipid Science and Technology》2021,123(2):2000126
The potential cardiovascular benefit of virgin olive oil (VOO) is widely recognized. However, the use of VOO at very high cooking temperatures makes these oils poorly suited for many Asian dishes. The use of tea seed oil (TSO) is increasing in Thailand, with TSO having a higher smoke point than VOO. The current study examines the effects of daily TSO intake in healthy adults. In a randomized, single-blind crossover design, 12 men consumed for 3 weeks 40 g day−1 of food prepared with either TSO or VOO as a cooking oil. Plasma lipids, thiobarbituric acid reactive substances (TBARS), and oxidant defense enzyme activities are measured before and after each 3-week intervention period. Gas chromatography analysis of TSO and VOO demonstrates that both oils are equally high in monounsaturated fatty acid. The dietary incorporation of TSO and VOO for three weeks reduces low-density lipoprotein cholesterol (LDL-C) concentrations by 15% and 13%, respectively; with total cholesterol (TC) levels lowered by 10% in both groups. No significant changes in TBARS or antioxidant enzyme activity is observed. These results support the concept that Thai TSO can be utilized as a suitable and healthy alternative oil for high-temperature cooking in many Thai and Asian diets. Practical Applications: Tea seed oil from Camellia oleifera grown in Thailand has been recently reported to favorably lower lipid profiles in hamsters fed a high-fat diet in a manner similar to feeding refined olive oil or grapeseed oil. A pilot crossover trial is conducted to compare the effects of three weeks of daily intake of either TSO or VOO in healthy human adults. Consumption of both oils produced significant reductions in TC and LDL-C. Thai TSO leads to favorable lipid profiles and is a reasonable choice for many Thai and Asian food recipes. 相似文献
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Raja Muhammad Asif Zahoor Naz Hira Shoaib Muhammad Mehmood Ammara 《Neural computing & applications》2022,34(7):5771-5790
Neural Computing and Applications - In the present study, a novel application of backpropagated neurocomputing heuristics (BNCH) is presented for epidemic virus model that portrays the Stuxnet... 相似文献
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Aaron D. Krabill Hao Chen Dr. Sajjad Hussain Dr. Chao Feng Dr. Ammara Abdullah Prof. Chittaranjan Das Dr. Uma K. Aryal Prof. Carol Beth Post Prof. Michael K. Wendt Prof. Paul J. Galardy Prof. Daniel P. Flaherty 《Chembiochem : a European journal of chemical biology》2020,21(5):712-722
The deubiquitinase (DUB) ubiquitin C-terminal hydrolase L1 (UCHL1) is expressed primarily in the central nervous system under normal physiological conditions. However, UCHL1 is overexpressed in various aggressive forms of cancer with strong evidence supporting UCHL1 as an oncogene in lung, glioma, and blood cancers. In particular, the level of UCHL1 expression in these cancers correlates with increased invasiveness and metastatic behavior, as well as poor patient prognosis. Although UCHL1 is considered an oncogene with potential as a therapeutic target, there remains a significant lack of useful small-molecule probes to pharmacologically validate in vivo targeting of the enzyme. Herein, we describe the characterization of a new covalent cyanopyrrolidine-based UCHL1 inhibitory scaffold in biochemical and cellular studies to better understand the utility of this inhibitor in elucidating the role of UCHL1 in cancer biology. 相似文献
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Mehmood Ammara Shi Peng Raja Muhammad Asif Zahoor Zameer Aneela Chaudhary Naveed Ishtiaq 《Neural computing & applications》2021,33(5):1479-1496
Neural Computing and Applications - This study presents a novel implementation of evolutionary heuristics through backtracking search optimization algorithm (BSA) for accurate, efficient and robust... 相似文献
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Clmentine Dillard Chlo Borde Ammara Mohammad Virginie Puchois Laurent Jourdren Annette K. Larsen Michle Sabbah Vincent Marchal Alexandre E. Escargueil Elodie Pramil 《International journal of molecular sciences》2021,22(21)
The purine nucleotide adenosine triphosphate (ATP) is known for its fundamental role in cellular bioenergetics. However, in the last decades, different works have described emerging functions for ATP, such as that of a danger signaling molecule acting in the extracellular space on both tumor and stromal compartments. Beside its role in immune cell signaling, several studies have shown that high concentrations of extracellular ATP can directly or indirectly act on cancer cells. Accordingly, it has been reported that purinergic receptors are widely expressed in tumor cells. However, their expression pattern is often associated with contradictory cellular outcomes. In this work, we first investigated gene expression profiles through “RNA-Sequencing” (RNA Seq) technology in four colorectal cancer (CRC) cell lines (HT29, LS513, LS174T, HCT116). Our results demonstrate that CRC cells mostly express the A2B, P2X4, P2Y1, P2Y2 and P2Y11 purinergic receptors. Among these, the P2Y1 and P2Y2 coding genes are markedly overexpressed in all CRC cells compared to the HCEC-1CT normal-like colonic cells. We then explored the cellular outcomes induced by extracellular ATP and adenosine. Our results show that in terms of cell death induction extracellular ATP is consistently more active than adenosine against CRC, while neither compound affected normal-like colonic cell survival. Intriguingly, while for the P2Y2 receptor pharmacological inhibition completely abolished the rise in cytoplasmic Ca2+ observed after ATP exposure in all CRC cell lines, Ca2+ mobilization only impacted the cellular outcome for HT29. In contrast, non-selective phosphodiesterase inhibition completely abolished the effects of extracellular ATP on CRC cells, suggesting that cAMP and/or cGMP levels might determine cellular outcome. Altogether, our study provides novel insights into the characterization of purinergic signaling in CRC. 相似文献
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Jianmin Yuan Ammara Usman Scott A. Reid Kevin F. King Andrew J. Patterson Jonathan H. Gillard Martin J. Graves 《Magma (New York, N.Y.)》2018,31(1):183-190
Objective
The purpose of this work is to evaluate the repeatability of a compressed sensing (CS) accelerated multi-contrast carotid protocol at 3 T.Materials and methods
Twelve volunteers and eight patients with carotid disease were scanned on a 3 T MRI scanner using a CS accelerated 3-D black-blood multi-contrast protocol which comprises T 1w, T 2w and PDw without CS, and with a CS factor of 1.5 and 2.0. The volunteers were scanned twice, the lumen/wall area and wall thickness were measured for each scan. Eight patients were scanned once, the inter/intra-observer reproducibility of the measurements was calculated.Results
In the repeated volunteer scans, the interclass correlation coefficient (ICC) for the wall area measurement using a CS factor of 1.5 in PDw, T 1w and T 2w were 0.95, 0.81, and 0.97, respectively. The ICC for lumen area measurement using a CS factor of 1.5 in PDw, T 1w and T 2w were 0.96, 0.92, and 0.96, respectively. In patients, the ICC for inter/intra-observer measurements of lumen/wall area, and wall thickness were all above 0.81 in all sequences.Conclusion
The results show a CS accelerated 3-D black-blood multi-contrast protocol is a robust and reproducible method for carotid imaging. Future protocol design could use CS to reduce the scanning time.7.
Abdul Rehman Javed Rabia Abid Bakhtawar Aslam Hafiza Ammara Khalid Mohammad Zubair Khan Omar H. Alhazmi Muhammad Rizwan 《计算机、材料和连续体(英文)》2021,67(2):1933-1950
With the popularity of green computing and the huge usage of networks, there is an acute need for expansion of the 5G network. 5G is used where energy efficiency is the highest priority, and it can play a pinnacle role in helping every industry to hit sustainability. While in the 5G network, conventional performance guides, such as network capacity and coverage are still major issues and need improvements. Device to Device communication (D2D) communication technology plays an important role to improve the capacity and coverage of 5G technology using different techniques. The issue of energy utilization in the IoT based system is a significant exploration center. Energy optimization in D2D communication is an important point. We need to resolve this issue for increasing system performance. Green IoT speaks to the issue of lessening energy utilization of IoT gadgets which accomplishes a supportable climate for IoT systems. In this paper, we improve the capacity and coverage of 5G technology using Multiple Inputs Multiple Outputs (MU-MIMO). MU-MIMO increases the capacity of 5G in D2D communication. We also present all the problems faced by 5G technology and proposed architecture to enhance system performance. 相似文献
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In order to develop and replace the expensive PtC catalyst from the fuel cells, we have attempted to synthesize an efficient catalyst for oxygen reduction reaction (ORR) in an alkaline media. The materials were initially fabricated as follows; (a) synthesizing a nitrogen doped (para-xylylenediamine, nitrogen precursor) graphene oxide (N-rGO); (b) synthesizing palladium nanoparticles on graphene oxide surface (rGO-Pd). The electrochemical analysis showed that the ORR path on the N-rGO catalyst is observed to follow 2-electron mechanism. Conversely, the onset potential, current density and surface area of the rGO-Pd doesn't match with the commercially available PtC catalyst. To overcome these flaws, we have combined the individual effects of each component and fabricated N-rGO-Pd nanocomposite. The covalent interaction between nitrogen part of para-xylylenediamine with oxygenated functionalities of GO, followed by a strong π–π stacking interaction between the aromatic ring of para-xylylenediamine and GO altered the electronic distribution of the carbon support, induced more defects, influenced the size and averted the self agglomeration of the Pd NPs which lead to the astonishing catalytic activity of N-rGO-Pd catalyst. Furthermore, various spectroscopic techniques revealed the individual influence of pyrrolic, pyridinic and graphitic–N on the synthesis, size and extraordinary distribution of Pd NPs. 相似文献
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