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1.
Tadeusz Zając Agnieszka Klimek-Kopyra Ryszard Mazurek Andrzej Oleksy Jacek Strojny 《Journal of Natural Fibers》2020,17(8):1199-1211
ABSTRACT Nine sowing densities of linseed were compared in a two-year experiment. Self-regulation of the density of a linseed stand resulted in a differentiated branching of the plants. The number of capsules on a linseed shoot, as well as seeds in the capsule, and the number of seeds from the shoot were highly varied from year to year, and there is even a stronger differentiation in the weight of 1000 seeds. Linear relationships were noted between the mass of seeds from the linseed plant and the number of capsules. The yield of linseed was affected by both factors. An increasing sowing rate reduced the seed yield from the shoot and the plant. At lower seeding rates, the lateral shoots contributed in the seeds yield of the plant to a higher degree compared to the main ones. 相似文献
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Anna Wawruszak Jarogniew Luszczki Marta Halasa Estera Okon Sebastian Landor Cecilia Sahlgren Adolfo Rivero-Muller Andrzej Stepulak 《International journal of molecular sciences》2021,22(10)
Histone deacetylase inhibitors (HDIs) are promising anti-cancer agents that inhibit proliferation of many types of cancer cells including breast carcinoma (BC) cells. In the present study, we investigated the influence of the Notch1 activity level on the pharmacological interaction between cisplatin (CDDP) and two HDIs, valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA, vorinostat), in luminal-like BC cells. The type of drug–drug interaction between CDDP and HDIs was determined by isobolographic analysis. MCF7 cells were genetically modified to express differential levels of Notch1 activity. The cytotoxic effect of SAHA or VPA was higher on cells with decreased Notch1 activity and lower for cells with increased Notch1 activity than native BC cells. The isobolographic analysis demonstrated that combinations of CDDP with SAHA or VPA at a fixed ratio of 1:1 exerted additive or additive with tendency toward synergism interactions. Therefore, treatment of CDDP with HDIs could be used to optimize a combined therapy based on CDDP against Notch1-altered luminal BC. In conclusion, the combined therapy of HDIs and CDDP may be a promising therapeutic tool in the treatment of luminal-type BC with altered Notch1 activity. 相似文献
4.
Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models
Beata Filip-Psurska Mateusz Psurski Artur Anisiewicz Patrycja Libako Ewa Zbrojewicz Magdalena Maciejewska Micha Chodyski Andrzej Kutner Joanna Wietrzyk 《International journal of molecular sciences》2021,22(5)
1,25-Dihydroxycholecalciferol, the hormonally active vitamin D3 metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering the expression of estrogen receptors and aromatase activity. Previously, the safety of the vitamin D active metabolite (24R)-1,24-dihydroxycholecalciferol (PRI-2191) and 1,25(OH)2D3 analog PRI-2205 was tested, and the in vitro activity of these analogs against different cancer cell lines was studied. We determined the effect of the two vitamin D compounds on anastrozole (An) activity against breast cancer based on antiproliferative activity, ELISA, flow cytometry, enzyme inhibition potency, PCR, and xenograft study. Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression. Combined with An, PRI-2191 and PRI-2205 significantly inhibited the tumor growth of MCF-7 cells. Potentiation of the antitumor activity in combined treatment of MCF-7 tumor-bearing mice is related to the reduced activity of aromatase by both An (enzyme inhibition) and vitamin D compounds (switched off/decreased aromatase gene expression, decreased expression of other genes related to estrogen signaling) and by regulation of the expression of the estrogen receptor ERα and VDR. 相似文献
5.
Andrzej Handkiewicz Pawel
niatala 《International Journal of Circuit Theory and Applications》1995,23(4):357-368
The paper presents a method of settling time minimization in switched capacitor (SC) circuits. This problem has been discussed in recent papers because of high-frequency applications of SC networks. In comparison with the methods elaborated up to now and limited to biquads, the method presented in this paper can be used for an SC circuit containing an arbitrary number of operational amplifiers coupled together in each switching state and modelled as ideal transconductances. the fifth-order ladder bilinear SC filter is considered for illustration of the method and SPICE simulations. 相似文献
6.
Andrzej Ciepielewski 《International journal of parallel programming》1991,20(6):421-451
Implementation of or-parallel Prolog systems offers a number of interesting scheduling problems. The main issues are the interaction between memory models and scheduling, ordering of multiple solutions, and scheduling of speculative work. The problems occur partly because of the design choices (e.g. the choice of a memory model), and partly because of the desire to maintain observational equivalence between parallel and sequential implementations of Prolog, while achieving high efficiency. In the first part of this paper a common framework for discussing scheduling in or-parallel systems is introduced, and also a collection of issues that must be addressed in such systems is presented. In the second part of the paper we survey a number of solutions to these problems comparing their efficiency whenever possible. We close the survey with a short discussion of open problems.Current association: Carlstedt Elektronik AB 相似文献
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The development of biaxial segmental orientation and stress in a flexible-chain polymer fluid subjected to steady biaxial extensional flow is analyzed. Closed-formula model based on the Padè approximation of the inverse Langevin function in the non-Gaussian distribution of the chain end-to-end vectors is considered. The approach is free from the limitations related to finite chain extensibility and slow convergence of the series expansion formulations at higher chain deformations.Segmental orientation is characterized by the average orientation tensor, related axial orientation factors and global orientation anisotropy. Orientational behavior and corresponding stresses in the biaxial elongational potential flow are discussed in a wide range of elongation rates. Orientation characteristics calculated for the biaxial flow deformation are much higher than those predicted for the affine biaxial stretch deformation in polymer solids. 相似文献
9.
The effect of methanol, acetone, formalin and glucose on the nitrification process in the packed bed reactors has been investigated. For the utilized compounds the inhibition constant Ki was determined according to Dixon's method. The determined values were as follows: methanol Ki = 116.0 mg l?1; acetone Ki = 804.2 mg l?1; formalin Ki = 61.5 mg l?1. The value of Ki for glucose has not been determined because glucose in applied concentration up to 11,325 mg l?1 had no effect on the nitrification course. 相似文献
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