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排序方式: 共有306条查询结果,搜索用时 15 毫秒
1.
Stefano Mariani Antonino Amedeo La Mattina Alessandro Paghi Lucanos Strambini Giuseppe Barillaro 《Advanced functional materials》2021,31(26):2100774
Here, a fluoride-assisted route for the controlled in-situ synthesis of metal nanoparticles (NPs) (i.e., AgNPs, AuNPs) on polydimethylsiloxane (PDMS) is reported. The size and coverage of the NPs on the PDMS surface are modulated with time and over space during the synthetic process, leveraging the improved yield (10×) and faster kinetics (100×) of NP formation in the presence of F− ions, compared to fluoride-free approaches. This enables the maskless preparation of both linear and step gradients and patterns of NPs in 1D and 2D on the PDMS surface. As an application in flexible plasmonics/photonics, continuous and step-wise spatial modulations of the plasmonic features of PDMS slabs with 1D and 2D AgNP gradients on the surface are demonstrated. An excellent spatially resolved tuning of key optical parameters, namely, optical density from zero to 5 and extinction ratio up to 100 dB, is achieved with AgNP gradients prepared in AgF solution for 12 minutes; the performance are comparable to those of commercial dielectric/interference filters. When used as a rejection filter in optical fluorescence microscopy, the AgNP-PDMS slabs are able to reject the excitation laser at 405 nm and retain the green fluorescence of microbeads (100 µm) used as test cases. 相似文献
2.
Colzato Lorenza S.; Raffone Antonino; Hommel Bernhard 《Canadian Metallurgical Quarterly》2006,32(3):705
Four experiments were conducted to investigate the relationship between the binding of visual features (as measured by their aftereffects on subsequent binding) and the learning of feature-conjunction probabilities. Both binding and learning effects were obtained, but they did not interact. Interestingly, (shape-color) binding effects disappeared with increasing practice, presumably because of the fact that only 1 of the features involved was relevant to the task. However, this instability was only observed for arbitrary, not highly overlearned combinations of simple geometric features and not for real objects (colored pictures of a banana and strawberry), where binding effects were strong and resistant to practice. These findings suggest that learning has no direct impact on the strength or resistance of bindings or on speed with which features are bound; however, learning does affect the amount of attention particular feature dimensions attract, which again can influence which features are considered in binding. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
3.
Amati Viviana; Werge Thomas M.; Cattaneo Antonino; Tramontane Anna 《Protein engineering, design & selection : PEDS》1995,8(4):403-408
Substance P G-protein coupled receptor and the antigen recognitionsite of a monoclonal antibody raised against substance P sharea stretch of five contiguous identical amino acids. This observationprompted us to build an atomic model of both the receptor andthe antibody and to analyse their common features. In particular,we report here that a pocket of similar size and compositionis present in both proteins, strongly suggesting a similarityin the mode of binding of both macromolecules to substance P.From the analysis of our models, the available data on the modeof binding of the antibody to substance P and recent data onsubstance P receptor mutants, we concluded that the pocket isvery likely to be involved in binding of the C-terminal 'messagesequence' of the tachykinin. This allowed us to suggest specificsite-directed mutants of the receptor which should shed somelight on the mechanism of peptide recognition by G-protein coupledreceptors. 相似文献
4.
Maria Chiara Mistretta Luigi Botta Francesco Paolo La Mantia Antonino Di Fiore Marco Cascone 《大分子材料与工程》2021,306(9):2100177
Films for agricultural applications, such as greenhouses films or mulching films are generally made of polyolefins such as linear low-density polyethylene (LLDPE) or low-density polyethylene. However, the use of biodegradable and/or compostable polymers is increasing, which enjoy the additional advantage that they can be left on the site since a fine life would be gradually assimilated to the underlying soil. Nevertheless, biodegradable polymeric films often do not have suitable mechanical performances. In this work, biodegradable polymer-based nanocomposite films are prepared by film blowing and compared with traditional LLDPE based nanocomposites. In particular, a biodegradable polymer blend and two different inorganic nanofillers (an organo-modified clay and a calcium carbonate with a hydrophobic coating) are used for the preparation of the nanocomposites. A detailed investigation of obtained materials is performed through rheological, mechanical, and optical characterizations. Adding nanofillers led to an increase of rigidity and tear strength of blown films without negatively affecting their ductility. 相似文献
5.
Filomena Impero Martin Dix Antonino Squillace Biagio Palumbo Flaviana Tagliaferri 《Materials and Manufacturing Processes》2018,33(12):1354-1360
This paper compares conventional and cryogenic cooling in the deep hole drilling of carbon fiber reinforced polymer (CFRP)/Ti stacks. Various parameters are taken into account to find if the use of cryogenic coolant is justified by the improvement of the final results. Both the thrust and the torque were acquired continuously during the machining operations and compared both in average and distribution. The use of a cryogenic coolant brings a reduction in thrust force and torque without any sensible drawback. Overall the results prove that cryogenic drilling is a suitable technology for CFRP/Ti stack drill. 相似文献
6.
Under natural viewing conditions, the physiological instability of visual fixation keeps the projection of the stimulus on the retina in constant motion. After eye opening, chronic exposure to a constantly moving retinal image might influence the experience-dependent refinement of cell response characteristics. The results of previous modeling studies have suggested a contribution of fixational instability to the Hebbian maturation of the receptive fields of V1 simple cells (Rucci, Edelman, & Wray, 2000; Rucci & Casile, 2004). This letter examines the origins of such a contribution. Using quasilinear models of lateral geniculate nucleus units and V1 simple cells, we derive analytical expressions for the second-order statistics of thalamocortical activity before and after eye opening. We show that in the presence of natural stimulation, fixational instability introduces a spatially uncorrelated signal in the retinal input, which strongly influences the structure of correlated activity in the model. This input signal produces a regime of thalamocortical activity similar to that present before eye opening and compatible with the Hebbian maturation of cortical receptive fields. 相似文献
7.
Antonino Valenza Chiara Borsellino Luigi Calabrese Guido Di Bella 《Applied Composite Materials》2006,13(4):217-235
Composite materials are widely employed in sailing sports, a possible application is for the mast pole or other sail poles. In the paper the attention is focused on the spinnaker poles mechanical performances; in particular the focus is on axial and ring compressive properties of three different carbon fibre/epoxy resin spinnaker poles, to investigate both the diameter and stacking sequence effect on the mechanical performance of the structure. Starting from the stacking sequence used in the production of a particular spinnaker pole, the effect of a lamina at 0° in the middle of wall thickness is investigated with the purpose to obtain a more stiff structure. Moreover to test the proposed stacking sequence on different size products, a prototype with lower diameter is realized. To properly evaluate axial and ring stiffness, axial compression test and ring stiffness one are performed. Then a numerical model is developed to support the design of the finished product: A simple and versatile numerical analysis (FEA with software ANSYS), by simulating ring stiffness and pull-direction compression tests, is carried out in elastic regime. Such model should be suitable for designing and/or verifying the mechanical performance of pole structures, even though differing from those above described, for materials, geometry and stacking sequence. 相似文献
8.
Antonino B. DAssoro Roberto Leon-Ferre Eike-Benjamin Braune Urban Lendahl 《International journal of molecular sciences》2022,23(11)
The Notch signaling pathway is an architecturally simple signaling mechanism, well known for its role in cell fate regulation during organ development and in tissue homeostasis. In keeping with its importance for normal development, dysregulation of Notch signaling is increasingly associated with different types of tumors, and proteins in the Notch signaling pathway can act as oncogenes or tumor suppressors, depending on the cellular context and tumor type. In addition to a role as a driver of tumor initiation and progression in the tumor cells carrying oncogenic mutations, it is an emerging realization that Notch signaling also plays a role in non-mutated cells in the tumor microenvironment. In this review, we discuss how aberrant Notch signaling can affect three types of cells in the tumor stroma—cancer-associated fibroblasts, immune cells and vascular cells—and how this influences their interactions with the tumor cells. Insights into the roles of Notch in cells of the tumor environment and the impact on tumor-stroma interactions will lead to a deeper understanding of Notch signaling in cancer and inspire new strategies for Notch-based tumor therapy. 相似文献
9.
Agnese Filippello Stefania Di Mauro Alessandra Scamporrino Sebastiano Alfio Torrisi Gian Marco Leggio Antonino Di Pino Roberto Scicali Maurizio Di Marco Roberta Malaguarnera Francesco Purrello Salvatore Piro 《International journal of molecular sciences》2022,23(14)
Intestinal cell dysfunctions involved in obesity and associated diabetes could be correlated with impaired intestinal cell development. To date, the molecular mechanisms underlying these dysfunctions have been poorly investigated because of the lack of a good model for studying obesity. The main aim of this study was to investigate the effects of lipotoxicity on intestinal cell differentiation in small intestinal organoid platforms, which are used to analyze the regulation of cell differentiation. Mouse intestinal organoids were grown in the presence/absence of high palmitate concentrations (0.5 mM) for 48 h to simulate lipotoxicity. Palmitate treatment altered the expression of markers involved in the differentiation of enterocytes and goblet cells in the early (Hes1) and late (Muc2) phases of their development, respectively, and it modified enterocytes and goblet cell numbers. Furthermore, the expression of enteroendocrine cell progenitors (Ngn3) and I cells (CCK) markers was also impaired, as well as CCK-positive cell numbers and CCK secretion. Our data indicate, for the first time, that lipotoxicity simultaneously influences the differentiation of specific intestinal cell types in the gut: enterocytes, goblet cells and CCK cells. Through this study, we identified novel targets associated with molecular mechanisms affected by lipotoxicity that could be important for obesity and diabetes therapy. 相似文献
10.
Eva Dreussi Erika Cecchin Jerry Polesel Vincenzo Canzonieri Marco Agostini Caterina Boso Claudio Belluco Angela Buonadonna Sara Lonardi Francesca Bergamo Sara Gagno Elena De Mattia Salvatore Pucciarelli Antonino De Paoli Giuseppe Toffoli 《International journal of molecular sciences》2016,17(9)
Background: Pathological complete response (pCR) to neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC) is still ascribed to a minority of patients. A pathway based-approach could highlight the predictive role of germline single nucleotide polymorphisms (SNPs). The primary aim of this study was to define new predictive biomarkers considering treatment specificities. Secondary aim was to determine new potential predictive biomarkers independent from radiotherapy (RT) dosage and cotreatment with oxaliplatin. Methods: Thirty germ-line SNPs in twenty-one genes were selected according to a pathway-based approach. Genetic analyses were performed on 280 LARC patients who underwent fluoropyrimidine-based CRT. The potential predictive role of these SNPs in determining pathological tumor response was tested in Group 1 (94 patients undergoing also oxaliplatin), Group 2 (73 patients treated with high RT dosage), Group 3 (113 patients treated with standard RT dosage), and in the pooled population (280 patients). Results: Nine new predictive biomarkers were identified in the three groups. The most promising one was rs3136228-MSH6 (p = 0.004) arising from Group 3. In the pooled population, rs1801133-MTHFR showed only a trend (p = 0.073). Conclusion: This exploratory study highlighted new potential predictive biomarkers of neoadjuvant CRT and underlined the importance to strictly define treatment peculiarities in pharmacogenetic analyses. 相似文献