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1.
In this paper, we present an aero‐structural model of a tethered swept wing for airborne wind energy generation. The carbon composite wing has neither fuselage nor actuated aerodynamic control surfaces and is controlled entirely from the ground using three separate tethers. The computational model is efficient enough to be used for weight optimisation at the initial design stage. The main load‐bearing wing component is a nontypical “D”‐shaped wing‐box, which is represented as a slender carbon composite shell and further idealised as a stack of two‐dimensional cross section models arranged along an anisotropic one‐dimensional beam model. This reduced 2+1D finite element model is then combined with a nonlinear vortex step method that determines the aerodynamic load. A bridle model is utilised to calculate the individual forces as a function of the aerodynamic load in the bridle lines that connect the main tether to the wing. The entire computational model is used to explore the influence of the bride on the D‐box structure. Considering a reference D‐box design along with a reference aerodynamic load case, the structural response is analysed for typical bridle configurations. Subsequently, an optimisation of the internal geometry and laminate fibre orientations is carried out using the structural computation models, for a fixed aerodynamic and bridle configuration. Aiming at a minimal weight of the wing structure, we find that for the typical load case of the system, an overall weight savings of approximately 20% can be achieved compared with the initial reference design. 相似文献
2.
Three-dimensional models, or pharmacophores, describing Euclidean constraints on the location on small molecules of functional
groups (like hydrophobic groups, hydrogen acceptors and donors, etc.), are often used in drug design to describe the medicinal
activity of potential drugs (or ‘ligands’). This medicinal activity is produced by interaction of the functional groups on
the ligand with a binding site on a target protein. In identifying structure-activity relations of this kind there are three
principal issues: (1) It is often difficult to “align” the ligands in order to identify common structural properties that
may be responsible for activity; (2) Ligands in solution can adopt different shapes (or `conformations’) arising from torsional
rotations about bonds. The 3-D molecular substructure is typically sought on one or more low-energy conformers; and (3) Pharmacophore
models must, ideally, predict medicinal activity on some quantitative scale. It has been shown that the logical representation
adopted by Inductive Logic Programming (ILP) naturally resolves many of the difficulties associated with the alignment and
multi-conformation issues. However, the predictions of models constructed by ILP have hitherto only been nominal, predicting
medicinal activity to be present or absent. In this paper, we investigate the construction of two kinds of quantitative pharmacophoric
models with ILP: (a) Models that predict the probability that a ligand is “active”; and (b) Models that predict the actual
medicinal activity of a ligand. Quantitative predictions are obtained by the utilising the following statistical procedures
as background knowledge: logistic regression and naive Bayes, for probability prediction; linear and kernel regression, for
activity prediction. The multi-conformation issue and, more generally, the relational representation used by ILP results in
some special difficulties in the use of any statistical procedure. We present the principal issues and some solutions. Specifically,
using data on the inhibition of the protease Thermolysin, we demonstrate that it is possible for an ILP program to construct
good quantitative structure-activity models. We also comment on the relationship of this work to other recent developments
in statistical relational learning.
Editors: Tamás Horváth and Akihiro Yamamoto 相似文献
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Pankaj Mathure Ashwin Patwardhan 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(4):413-419
In this study, the mass transfer efficiencies of a novel horizontal rotating packed (h‐RPB) bed and the conventional disc‐type rotating biological contactor (RBC) were studied at four speeds and seven submergences. Pall rings of two different sizes (25, 38 mm), superintalox saddles and a wiremesh spiral bundle were used as packings in the h‐RPB. Volumetric gas–liquid mass transfer coefficients were determined by unsteady state absorption of atmospheric oxygen in de‐aerated water. Power consumption per unit liquid volume has been found for all geometries tested. The oxygen transfer efficiency values for the h‐RPB were found to be 2–5 kg kWh?1 and for the disc RBC were found to be 1–2 kg kWh?1. The performance of the h‐RPB was also compared with other gas–liquid contactors such as surface aerators. The study proves that the h‐RPB is a energy efficient alternative to conventional contactors. Copyright © 2005 Society of Chemical Industry 相似文献
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Ashwin Kumar Vutha Benyamin Davaji Chung Hoon Lee Glenn M. Walker 《Microfluidics and nanofluidics》2014,17(5):871-878
We demonstrate the use of heat to count microscopic particles. A thermal particle detector (TPD) was fabricated by combining a 500-nm-thick silicon nitride membrane containing a thin-film resistive temperature detector with a silicone elastomer microchannel. Particles with diameters of 90 and 200 μm created relative temperature changes of 0.11 and ?0.44 K, respectively, as they flowed by the sensor. A first-order lumped thermal model was developed to predict the temperature changes. Multiple particles were counted in series to demonstrate the utility of the TPD as a particle counter. 相似文献
7.
Ashwin S. Dhabale Rutuja Dive Mohan V. Aware Shantanu Das 《Asian journal of control》2015,17(6):2143-2152
In this paper a new algorithm is presented to calculate the poles and zeros to approximate a fractional order (FO) differintegral (s±α,α∈(0,1)) by a rational function on a finite frequency band ω∈(ωl,ωh). The constant phase property of the FO differintegral is the basis for development of the algorithm. Interlacing of real poles and zeros is used to achieve the constant phase. The calculations are done using the asymptotic Bode phase plot. A brief investigation is made to get a good approximation for the Bode phase plot. Two design parameters are introduced to keep the average phase close to the desired phase angle and to keep the error within the allowed bounds. A study is done to empirically understand the relationship between the error and the design parameters. The results thus obtained help in the further calculations. The algorithm is computationally simple and inexpensive, and gives a fairly good approximation of fractance frequency response on the specified frequency band. 相似文献
8.
Suresh Kumar S. Ashwin Clement H. Karthik R. 《Journal of Failure Analysis and Prevention》2017,17(4):780-787
Journal of Failure Analysis and Prevention - In the present work, mixed-mode stress intensity factor (SIF) of multiple cracks in a riveted lap joint has been determined, with and without the... 相似文献
9.
Traumatic brain injury (TBI) is a devastating injury with severe consequences. In this paper, we conduct a simulation study on the commonly implemented care delivery process for TBI rehabilitation in the US, which covers three care categories: inpatient acute, outpatient sub-acute and general residential care. Our investigation is focused on assessing how coverage duration of publicly funded rehabilitation impacts two key system outcomes: sub-acute rehabilitation readmission and total rehabilitation spending. We develop prediction models on the above two outcomes for patients of different conditions. We introduce the notions of forceful transition and medical necessity adjustment, and embed the notions in a state-transition simulation model. Our simulation results suggest that to minimise the care spending, the duration of publicly insured outpatient sub-acute rehab be set smaller than what is currently implemented but not to the point where coverage should be completely removed. Our sensitivity analysis justifies the robustness of our results under variations on model parameters. 相似文献
10.
Guanyao Huang Ashwin Lall Chen-Nee Chuah Jun Xu 《Journal of Network and Systems Management》2011,19(1):84-110
Discovering icebergs in distributed streams of data is an important problem for a number of applications in networking and
databases. While previous work has concentrated on measuring these icebergs in the non-distributed streaming case or in the
non-streaming distributed case, we present a general framework that allows for distributed processing across multiple streams
of data. We compare several of the state-of-the-art streaming algorithms for estimating local elephants in the individual
streams. However, since an iceberg may be hidden by being distributed across many different streams, we add a sampling component
to handle such cases. We provide a novel taxonomy of current sketches and perform a thorough analysis of the strengths and
weaknesses of each scheme under various QoS metrics, using both real and synthetic Internet trace data. We summarize their
performance and discuss the implications for the future design of sketches. 相似文献