Ir(III) and Ru(II) Complexes in Photoredox Catalysis and Photodynamic Therapy: A New Paradigm towards Anticancer Applications

Individually, photoredox catalysis (PC) and photodynamic therapy (PDT) are well-established concepts that have experienced a remarkable resurgence in recent years, leading to significant progress in organic synthesis for PC and clinical approval of anticancer drugs for PDT. But, very recently, new photoredox catalyst systems based on Ir(III) and Ru(II) complexes have garnered significant interest because they can simultaneously be used as PDT agents apart from their demonstrated PC activity. This highlight discusses the unique PC behavior of emerging Ir(III)- and Ru(II)-based systems while also examining their potential PDT activity in cancer treatment.     

On the synergy between electrical and photonic switching

This article focuses on the values of electrical switching vs. photonic switching in the context of telecom transport networks. In particular, we show that the requirement of providing agility at the optical layer in the face of traffic forecast uncertainties is served better through photonic switching. On the other hand, some of the network-level functions, such as fast protection, subwavelength aggregation, and flexible client connectivity, require electrical switching. We further argue that additional values are achieved with hybrid photonic and electrical switching, which do not exist when either of these options is used in isolation.     

Design of sample adaptive product quantizers for noisy channels

Channel-optimized vector quantization (COVQ) has proven to be an effective joint source-channel coding technique that makes the underlying quantizer robust to channel noise. Unfortunately, COVQ retains the high encoding complexity of the standard vector quantizer (VQ) for medium-to-high quantization dimensions and moderate-to-good channel conditions. A technique called sample adaptive product quantization (SAPQ) was recently introduced by Kim and Shroff to reduce the complexity of the VQ while achieving comparable distortions. In this letter, we generalize the design of SAPQ for the case of memoryless noisy channels by optimizing the quantizer with respect to both source and channel statistics. Numerical results demonstrate that the channel-optimized SAPQ (COSAPQ) achieves comparable performance to the COVQ (within 0.2 dB), while maintaining considerably lower encoding complexity (up to half of that of COVQ) and storage requirements. Robustness of the COSAPQ system against channel mismatch is also examined.     

Noninterfering optical method of HBT circuit evaluation

The authors report a novel noninterfering and simple approach for evaluation of circuits implemented with AlGaAs/GaAs heterojunction bipolar transistors (HBTs). This method makes use of radiative recombination in the base region of current-carrying HBTs. The infrared radiation emitted is 'visible' to the closed-circuit TV (CCTV) cameras. Therefore, one can view the operation of the HBT circuit under test at normal biases with a TV monitor. This method can be used to determine logic states of gates, as well as collector current of individual HBTs within integrated circuits.<>     

Hyperspectral imaging-based unsupervised adulterated red chili content transformation for classification: Identification of red chili adulterants

Neural Computing and Applications - Preserving red-chili quality is of utmost importance in which the authorities demand quality techniques to detect, classify, and prevent it from impurities. For...     

Catalase (CAT) Gene Family in Rapeseed (Brassica napus L.): Genome-Wide Analysis,Identification, and Expression Pattern in Response to Multiple Hormones and Abiotic Stress Conditions

Catalase (CAT) is an antioxidant enzyme expressed by the CAT gene family and exists in almost all aerobic organisms. Environmental stresses induce the generation of reactive oxygen species (ROS) that eventually hinder plant growth and development. The CAT enzyme translates the hydrogen peroxide (H₂O₂) to water (H₂O) and reduce the ROS levels to shelter the cells’ death. So far, the CAT gene family has not been reported in rapeseed (Brassica napus L.). Therefore, a genome-wide comprehensive analysis was conducted to classify the CAT genes in the rapeseed genome. The current study identified 14 BnCAT genes in the rapeseed genome. Based on phylogenetic and synteny analysis, the BnCATs belong to four groups (Groups I–IV). A gene structure and conserved motif analysis showed that Group I, Group II, and Group IV possess almost the same intron/exon pattern, and an equal number of motifs, while Group III contains diverse structures and contain 15 motifs. By analyzing the cis-elements in the promoters, we identified five hormone-correlated responsive elements and four stress-related responsive elements. Further, six putative bna-miRNAs were also identified, targeting three genes (BnCAT4, BnCAT6, and BnCAT8). Gene ontology (GO) enrichment analysis showed that the BnCAT genes were largely related to cellular organelles, ROS response, stimulus response, stress response, and antioxidant enzymes. Almost 10 BnCAT genes showed higher expression levels in different tissues, i.e., root, leaf, stem, and silique. The expression analysis showed that BnCAT1–BnCAT3 and BnCAT11–BnCAT13 were significantly upregulated by cold, salinity, abscisic acid (ABA), and gibberellic acid (GA) treatment, but not by drought and methyl jasmonate (MeJA). Notably, most of the genes were upregulated by waterlogging stress, except BnCAT6, BnCAT9, and BnCAT10. Our results opened new windows for future investigations and provided insights into the CAT family genes in rapeseed.     

An open-source multi-DOF articulated robotic educational platform for autonomous object manipulation

This research presents an autonomous robotic framework for academic, vocational and training purpose. The platform is centred on a 6 Degree Of Freedom (DOF) serial robotic arm. The kinematic and dynamic models of the robot have been derived to facilitate controller design. An on-board camera to scan the arm workspace permits autonomous applications development. The sensory system consists of position feedback from each joint of the robot and a force sensor mounted at the arm gripper. External devices can be interfaced with the platform through digital and analog I/O ports of the robot controller. To enhance the learning outcome for beginners, higher level commands have been provided. Advanced users can tailor the platform by exploiting the open-source custom-developed hardware and software architectures. The efficacy of the proposed platform has been demonstrated by implementing two experiments; autonomous sorting of objects and controller design. The proposed platform finds its potential to teach technical courses (like Robotics, Control, Electronics, Image-processing and Computer vision) and to implement and validate advanced algorithms for object manipulation and grasping, trajectory generation, path planning, etc. It can also be employed in an industrial environment to test various strategies prior to their execution on actual manipulators.     

What can possibly go wrong? Anticipatory work in space operations

This paper explores how different forms of anticipatory work contribute to reliability in high-risk space operations. It is based on ethnographic field work, participant observation and interviews supplemented with video recordings from a control room responsible for operating a microgravity greenhouse at the International Space Station (ISS). Drawing on examples from different stages of a biological experiment on the ISS, we demonstrate how engineers, researchers and technicians work to anticipate and proactively mitigate possible problems. Space research is expensive and risky. The experiments are planned over the course of many years by a globally distributed network of organizations. Owing to the inaccessibility of the ISS, every trivial detail that could possibly cause a problem is subject to scrutiny. We discuss what we label anticipatory work: practices constituted of an entanglement of cognitive, social and technical elements involved in anticipating and proactively mitigating everything that might go wrong. We show how the nature of anticipatory work changes between planning and the operational phases of an experiment. In the planning phase, operators inscribe their anticipation into technology and procedures. In the operational phase, we show how troubleshooting involves the ability to look ahead in the evolving temporal trajectory of the ISS operations and to juggle pre-planned fixes along these trajectories. A key objective of this paper is to illustrate how anticipation is shared between humans and different forms of technology. Moreover, it illustrates the importance of including considerations of temporality in safety and reliability research.     

直觉线性μ-演算

线性mu-演算(μTL)是线性时序逻辑(LTL)的不动点扩展.LTL是一个便于规范和论证反应式系统的方法.μTL作为比LTL表达能力更强的逻辑,用LTL表示的性质度可由μTL表示.类似于LTL的直觉线性时序逻辑(ILTL),提出一种基于直觉解释的μTL,称为直觉μTL(IμTL).确立了IμTL和ILTL的关系,比较了它们之间的表达能力.讨论了使用IμTL与安全性质和活性描述的关系以及描述"假设-保证"规范的问题.